Summary
Evidence is presented suggesting that endocrine and immunomodulating activities of estrogens, progestogens and androgens are often not correlated. The consequences of such a possible lack of correlation is discussed. The possibility to dissociate endocrine and immunomodulating activities may lead to novel compounds for treating autoimmune diseases.
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References
G.T. Erbach and J.M. Bahr, Effect of chronic or cyclic exposure to estradiol on the humoral immune response and the thymus, Immunopharmacology 16:45 (1988).
A.H.W.M. Schuurs and H.A.M. Verheul, Effect of gender and sex steroids on the immune response, J. Steroid Biochem. 35:157 (1990).
F. Homo-Delarche, F. Fitzpatrick, N. Christeff, E.A. Nunez, J.F. Bach, and M. Dardenne, Sex steroids, glucocorticoids, stress and autoimmunity, J. Steroid Biochem. Molec. Biol 40:619 (1991).
C.J. Grossman, G A. Roselle, and C.L. Mendenhall, Sex steroid regulation of autoimmunity, J. Steroid Biochem. Molec. Biol. 40:649 (1991).
T. Nicol, D.L.J. Bilbey, L.M. Charles, J.L. Cordingley, and B. Vernon-Roberts, Oestrogen: the natural stimulant of body defence, J. Endocrinol. 30:277 (1964).
A.D. Schreiber, F.M. Nettl, M.C. Sanders, M. King, P. Szabolcs, D. Friedman, and F. Gomez, Effect of endogenous and synthetic sex steroids on the clearance of antibody-coated cells, J. Immunol. 141:2959 (1988).
R.W. Pfeifer and R.M. Patterson, Modulation of lymphokine-induced macrophage activation by estrogen metabolites, J. Immunopharmacol. 7:247 (1985).
C. Martucci and J. Fishman, Uterine estrogen receptor binding of catecholestrogens and estetrol (1,3,5(10)-estratriene-3,15a,16a,17b-tetrol), Steroids 27:325 (1976).
R.W. Pfeifer and R.M. Patterson, Modulation of nonspecific cell-mediated growth inhibtion by estrogen metabolites, Immunopharmacology 10:127 (1985).
R.W. Pfeifer and R.M. Patterson, Modulation of lectin-stimulated lymphocyte agglutination and mitogenesis by estrogen metabolites: effects of early events of lymphocyte activation, Arch. Toxicol. 58:157 (1986).
R.L. Aspinall, R.K. Meyer and M.A. Rao, Effect of various steroids on the development of the bursa Fabricii in chick embryos, Endocrinology 68:944 (1961).
J. de Visser, A. Coert, H. Feenstra, and J. van der Vies, Endocrinological studies with (7a,17a)-17-hydroxy-7-methyl-19-norpregn-5(10)-3n-20-yn-3-one (Org OD 14), Arzneim. Forsch./Drug Res. 9:1010 (1984).
J.K. Bhanushali, K.K. Murthy and W.L. Ragland, Effect of androgens on the ontogeny of humoral immunity in chickens, in: “Chemical Regulation of Immunity in Veterinary Medicine,” Alan R. Liss, Inc., New York (1984).
B. Glick, T.S. Chang, and R.G. Jaap, The bursa of Fabricius and antibody production in the domestic fowl, Poult. Sci. 35:224 (1956).
N.L. Warner and F.M. Burnet, The influence of testosterone on the development of the bursa of Fabricius in chick embryo, Aust. J. Biol. Sci. 14:580 (1961).
R.K. Meyer, M.A. Rao, and R.L. Aspinall, Inhibition of the development of the bursa of Fabricius in the embryos of the common fowl by 19-nortestosterone, Endocrinology 64:890 (1959).
H.A.M. Verheul, E.V. Tittes, J. Kelder and A.H.W.M. Schuurs, Effect of steroids with different endocrine profiles on development, morphology and function of the bursa of Fabricius in chickens, J. Steroid Biochem. 25:665 (1986).
A.H.W.M. Schuurs, G.H.J. Deckers, L.P.C. Schot, and H.A.M. Verheul, Lack of correlation between endocrinological and immunological effects of androgen-derived steroids, in: “Hormones and Immunity,” I. Berczi, K. Kovacs, eds., MTP Press, Lancaster, UK (1987).
H.A.M. Verheul, W.H. Stimson, F.C. den Hollander and A.H.W.M. Schuurs, Effects of nandrolone, testosterone and their decanoate esters on murine lupus, Clin. Exp. Immunol. 44:11 (1981).
H.A.M. Verheul, G.H.J. Deckers and A.H.W.M. Schuurs, Effects of nandrolone or testosterone decanoate on murine lupus: further evidence for a dissociation of immune and endocrine effects, Immunophartnacology 11:93 (1986).
J.F. Hulka, K. Mohr, and M.W. Lieberman, Effect of synthetic progestational agents on allograft rejection and circulating antibody production, Endocrinology 77:897 (1965).
T. Mori, H. Kobayashi, H. Nishimoto, A. Suzumi, T. Nishimura, and T. Mori, Inhibitory effect of progesterone and 20a-hydroxypregn-4-en-3-one on the phytohemagglutinin-induced transformation of human lymphocytes, Am. I. Obstet. Gynecol. 127:151 (1977).
H.A.M. Verheul, L.P.C. Schot, G.H.J. Deckers and A.H.W.M. Schuurs, Effects of tibolone, lynestrenol, ethylestrenol and desogestrel on immune disorders in NZB/W mice, Clin. Immunol. Immunopathol. 38:198 (1986).
H.A.M. Verheul, L.P.C. Schot and A.H.W.M. Schuurs, Effects of nandrolone decanoate, tibolone, lynestrenol and ethylestrenol on Sjogren’s syndrome-like disorders in NZB/W mice, Clin. Exp. Immunol. 64:243 (1986).
L.W. Keisler, A.B. Kier and S.E. Walker, Effects of prolonged administration of the 19-nortestosterone derivatives norethindrone and norgestrel to female NZB/W mice: comparison with medroxyprogesterone and ethinyl estradiol, Autoimmunity 9:21 (1991).
F. Neumann, The physiological action of progesterone and the pharmacological effects of progestogens — a short review, Postgrad. Med. J. 54(suppl 2):11 (1978).
Z.M. Sthoeger, N. Chiorazzi and R.G. Lahita, Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testosterone on pokeweed mitogen-induced human B cell differentiation, J. Immunol. 141:91 (1988).
D. Catanzano-Troutaud, D. Ardail and PA. Deschaux, Testosterone inhibits the immunostimulant effect of thymosin fraction 5 on secondary immune response in mice, Int. J. Immunopharmacol. 14:263 (1992).
Y. Yamamoto, H. Saito, T. Setogawa and H. Tomioka, Sex differences in host resistance to Mycobacterium marinum infection in mice, Infect. Immun. 59:4089 (1991).
W.P.M. Benten, U. Bettenhaeuser, F. Wunderlich, E. van Vliet and H. Mossmann, Testosterone-induced abrogation of self-healing of Plasmodium chabaudi malaria in B10 mice: mediation by spleen cells, Infect. Immun. 59:4486 (1991).
A.H.W.M. Schuurs, H. Dietrich, J. Gruber and G. Wick, Effects of sex steroid analogs on spontaneous autoimmune thyroiditis in Obese Strain chickens, Int. Arch. Allergy Immunol. 97:337 (1992).
W.M. Bagchus, T. Coenen, A. van Doornmalen, J. Dulos, A.H.W.M. Schuurs and H.A.M. Verheul, Immunotherapy with an androgen-derived steroid (Org 4094) on autoimmune diseases in NZB/W and NOD mice, 8th Int. Cong. Immunol., Budapest, Hungary, Abstract W-87 #1 (1992).
H.A.M. Verheul, M. Verveid, G.H.J. Deckers, W.M. Bagchus and A.H.W.M. Schuurs, Dissociation of endocrine and autoimmunosuppresssive properties of androgen-derived steroids in the NZB/W and NOD mice, Am. College Rheumatol., 56th Annual Scientific Meeting, Atlanta, Georgia, Abstract P0331 (1992).
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Schuurs, A.H.W.M., Deckers, G.H.J., Verheul, H.A.M. (1994). Immunoregulation by Sex Hormone Analogues. In: Berczi, I., Szélenyi, J. (eds) Advances in Psychoneuroimmunology. Hans Selye Symposia on Neuroendocrinology and Stress, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9104-4_18
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