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Androgen Regulation of Ocular Mucosal- and Auto-Immunity

  • Chapter
Advances in Psychoneuroimmunology

Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HSSN,volume 3))

  • 62 Accesses

Abstract

At present, it is known that androgens exert a tremendous impact on the development, expression and function of the immune system in both health and disease. In brief, these hormones have been shown to: [a] influence the maturation, proliferation and/or activity of pluripotent stem cells, B cells, T cells and macrophages; [b] modulate the synthesis, secretion and/or action of antibodies, cytokines and growth factors; [c] alter the production of autoantibodies and the formation of immune complexes; [d] affect the immune response to, and clearance of, antigens; [e] control the generation of thymic factors and secretory component (SC), the IgA antibody receptor; and [f] modify the rejection of allografts, the extent of graft vs. host disease, the magnitude of inflammation, and the onset and severity of autoimmune disease.e.g.1–6 The precise nature of these androgen actions is exceedingly dependent upon the specific target cell, the local microenvironment, and the particular immunological process, and may result in enhancement, inhibition, or no effect, on immune expression.3 Nevertheless, it is quite apparent that androgens control multiple aspects of humoral, cell-mediated, mucosal and auto-immunity.

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References

  1. S.A. Ahmed, and N. Talal, Sex hormones and the immune system, Bailliere’s Clin. Rheum. 4:13 (1990).

    Article  CAS  Google Scholar 

  2. F. Homo-Delarche, F. Fitzpatrick, N. Christeff, E.A. Nunez, J.F. Bach, and M. Dardenne, Sex Steroids, glucocorticoids, stress and autoimmunity, J. Ster. Biochem. Mol. Biol. 40:619 (1991).

    Article  CAS  Google Scholar 

  3. D.A. Sullivan, Hormonal influence on the secretory immune system of the eye, in: “The Neuroendocrine-Immune Network,” S. Freier, ed., CRC Press, Boca Raton, FL, pp 199–238 (1990).

    Google Scholar 

  4. A.H.W.M. Schuurs, and H.A.M. Verheul, Effect of gender and sex steroids on the immune response,J. Steroid Biochem. 35:157 (1990).

    Article  PubMed  CAS  Google Scholar 

  5. A.B. McCruden, and W.H. Stimson, Sex hormones and immune function, in: “Psychoneuroimmunology,” R. Ader, D. Feiten, and N. Cohen, eds., Acad. Press, San Diego, CA (1991).

    Google Scholar 

  6. N.J. Olsen, P. Zhou, H. Ong, and W.J. Kovacs, Testosterone induces expression of transforming growth factor-beta 1 in the murine thymus. J. Steroid Biochem. Mol. Biol. 45:327 (1993).

    Article  PubMed  CAS  Google Scholar 

  7. D.A. Sullivan, Ocular mucosal immunity, in: “Mucosal Immunology,” P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J. McGhee, and J. Bienenstock, eds., Academic Press, Orlando, FL (1994).

    Google Scholar 

  8. D.A. Sullivan, and E.H. Sato, Potential therapeutic approach for the hormonal treatment of lacrimal gland dysfunction in Sjogren’s syndrome, Clin. Immunol. Immunopath. 64:9 (1992).

    Article  CAS  Google Scholar 

  9. D.A. Sullivan, Possible mechanisms involved in the reduced tear secretion in Sjogren’s syndrome, in: “Proceedings of the IVth International Symposium on Sjogren’s Syndrome,” Kluger Press, Amsterdam, in press (1994).

    Google Scholar 

  10. M.G. Friedman, Antibodies in human tears during and after infection, Surv. Ophthalmol. 35:151 (1990).

    Article  PubMed  CAS  Google Scholar 

  11. N.K. Childers, M.G. Bruce, and J.R. McGhee, Molecular mechanisms of immunoglobulin A defense, Annu. Rev. Microbiol. 43:503 (1989).

    Article  PubMed  CAS  Google Scholar 

  12. T.T. MacDonald, S.J. Challacombe, P.W. Bland, CR. Stokes, R.V. Heatley, and A. McI Mowat, eds. “Advances in Mucosal Immunology,” Kluwer Academic Publishers, London (1990).

    Google Scholar 

  13. D.A. Sullivan, K.J. Bloch, and M.R. Allansmith, Hormonal influence on the secretory immune system of the eye: androgen regulation of secretory component levels in rat tears, J. Immunol. 132:1130 (1984).

    PubMed  CAS  Google Scholar 

  14. D.A. Sullivan, K.J. Bloch, and M.R. Allansmith, Hormonal influence on the secretory immune system of the eye: androgen control of secretory component production by the rat exorbital gland, Immunology 52:239 (1984).

    PubMed  CAS  Google Scholar 

  15. D.A. Sullivan, and M.R. Allansmith, Hormonal influence on the secretory immune system of the eye: androgen modulation of IgA levels in tears of rats, J. Immunol. 134:2978 (1985).

    PubMed  CAS  Google Scholar 

  16. D.A. Sullivan, and L.E. Hann, Hormonal influence on the secretory immune system of the eye: endocrine impact on the lacrimal gland accumulation and secretion of IgA and IgG, J. Steroid Biochem. 34:253 (1989).

    Article  PubMed  CAS  Google Scholar 

  17. D.A. Sullivan, R.S. Kelleher, J.P. Vaerman, and L.E. Hann, Androgen regulation of secretory component synthesis by lacrimal gland acinar cells in vitro, J. Immunol. 145:4238 (1990).

    PubMed  CAS  Google Scholar 

  18. R.S. Kelleher, L.E. Hann, JA. Edwards, and D.A. Sullivan, Endocrine, neural and immune control of secretory component output by lacrimal gland acinar cells, J. Immunol. 146:3405 (1991).

    PubMed  CAS  Google Scholar 

  19. L.E. Hann, R.S. Kelleher, and D.A. Sullivan, Influence of culture conditions on the androgen control of secretory component production by acinar cells from the lacrimal gland, Invest. Ophthalmol. Vis. Sci. 32:2610 (1991).

    PubMed  CAS  Google Scholar 

  20. R.W. Lambert, R.S. Kelleher, L.A. Wickham, J.P. Vaerman, and D.A. Sullivan, Neuroendocrinimmune modulation of secretory component production by rat lacrimal, salivary and intestinal epithelial cells, Invest. Ophthalmol. Vis. Sci., in press (1994).

    Google Scholar 

  21. D.A. Sullivan, L.E. Hann, and J.P. Vaerman, Selectivity, specificity and kinetics of the androgen regulation of the ocular secretory immune system, Immunol. Invest. 17:183 (1988).

    Article  PubMed  CAS  Google Scholar 

  22. D.A. Sullivan, E.B. Colby, L.E. Hann, M.R. Allansmith, and CR. Wira, Production and utilization of a mouse monoclonal antibody to rat IgA: identification of gender-related differences in the secretory immune system, Immunol. Invest. 15:311 (1986).

    Article  PubMed  CAS  Google Scholar 

  23. D.A. Sullivan, and M.R. Allansmith, The effect of aging on the secretory immune system of the eye. Immunology 63:403 (1988).

    PubMed  CAS  Google Scholar 

  24. L.E. Hann, M.R. Allansmith, and D.A. Sullivan, Impact of aging and gender on the Ig-containing cell profile of the lacrimal gland, Acta Ophthalmologica 66:87 (1988).

    Article  PubMed  CAS  Google Scholar 

  25. D.A. Sullivan, L.E. Hann, L. Yee, and M.R. Allansmith, Age- and gender-related influence on the lacrimal gland and tears, Acta Opthalmologica 68:189 (1990).

    Google Scholar 

  26. P. Weisz-Carrington, M.E. Roux, M. McWilliams, J.M. Phillips Quagliata, and M.E. Lamm, Hormonal induction of the secretory immune system in the mammary gland, Proc. Natl. Acad. Seci. U.S.A. 75:2928 (1978).

    Article  CAS  Google Scholar 

  27. Z. Huang, R.W. Lambert, L.A. Wickham, and D.A. Sullivan, Influence of the endocrine environment on herpes virus infection in rat lacrimal gland acinar cells, in: “Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance,” D.A. Sullivan, B.B. Bromberg, M.M. Cripps, D.A. Dartt, D.L. MacKeen, A.K. Mircheff, P.C. Montgomery, K. Tsubota, and B. Walcott, eds., Adv. Exp. Med. Biol., in press (1994).

    Google Scholar 

  28. D.A. Sullivan, J. Edwards, C. Soo, B.D. Sullivan, F.J. Rocha, and E.H. Sato, Influence of steroids and immunosuppressive compounds on tear IgA levels in a mouse model of Sjogren’s syndrome, Invest. Ophthalmol. Vis. Sci. Suppl. 33:845 (1992).

    Google Scholar 

  29. D.A. Sullivan, and M.R. Allansmith, Hormonal influence on the secretory immune system of the eye: endocrine interactions in the control of IgA and secretory component levels in tears of rats. Immunology 60:337 (1987).

    PubMed  CAS  Google Scholar 

  30. D.A. Sullivan, Influence of the hypothalamic-pituitary axis on the androgen regulation of the ocular secretory immune system, J. Steroid Biochem. 30:429 (1988).

    Article  PubMed  CAS  Google Scholar 

  31. M. Martinazzi, Effetti dell’ipofisectomia sulla ghiandola lacrimale extraorbitale del ratto, Folia Endocrinol 150:120 (1962).

    Google Scholar 

  32. D.A. Sullivan, and M.R. Allansmith, Hormonal modulation of tear volume in the rat, Exp. Eye Res. 42:131 (1986).

    Article  PubMed  CAS  Google Scholar 

  33. Y. Hosoya, M. Matsushita, and Y. Sugiura, A direct hypothalamic projection to the superior salivatory nucleus neurons in the rat. A study using anterograde autoradiographic and retrograde HRP methods, Brain Res. 266:329 (1983).

    Article  PubMed  CAS  Google Scholar 

  34. J.D. Wilson, and D.W. Foster, eds. “Williams Textbook of Endocrinology,” W.B. Saunders Company, Philadelphia, PA (1985).

    Google Scholar 

  35. I. Berczi, Neurohormonal-immune interaction, in: “Functional Endocrine Pathology,” K. Kovacs, and S. Asa, eds., Blackwell Scientific Publications Inc., United Kingdom, p. 990 (1990).

    Google Scholar 

  36. I. Berczi, and E. Nagy, Effects of hypophysectomy on immune function, in: “Psychoneuroimmunology II,” R. Ader, D. L. Feiten, and N. Cohen, eds., Academic Press, San Diego, CA., p. 339 (1990).

    Google Scholar 

  37. A.D. Mooradian, J. E. Morley, and S. G. Korenman, Biological actions of androgens, Endocrine Rev. 8:1 (1987).

    Article  CAS  Google Scholar 

  38. F.L. Jackson, and J.C. Hutson, Altered responses to androgen in diabetic male rats, Diabetes 33:819 (1984).

    Article  PubMed  CAS  Google Scholar 

  39. P. Mauduit, G. Herman, and B. Rossignol, Protein secretion induced by isoproterenol or pentoxifylline in lacrimal gland: Ca2+ effects, Am. J. Physiol. 246:C37 (1984).

    Google Scholar 

  40. D. Dartt, Signal transduction and control of lacrimal gland protein secretion: a review. Curr. Eye Res. 8: 619 (1989).

    Article  PubMed  CAS  Google Scholar 

  41. J.E. Jumblatt, G. T. North, and R. C. Hackmiller, Muscarinic cholinergic inhibition of adenylate cyclase in the rabbit iris-ciliary body and ciliary epithelium. Invest. Ophthalmol. Vis. Sci. 31:1103 (1990).

    PubMed  CAS  Google Scholar 

  42. M. Ota, S. Kyakumoto, and T. Nemoto, Demonstration and characterization of cytosol androgen receptor in rat exorbital lacrimal gland, Biochem. Internat. 10:129 (1985).

    CAS  Google Scholar 

  43. JA. Edwards, R.S. Kelleher, and D.A. Sullivan, Identification of dihydrotestosterone binding sites in the rat lacrimal gland, Invest. Ophthalmol. Vis. Sci. Suppl. 31:541 (1990).

    Google Scholar 

  44. F.J. Rocha, L.A. Wickham, J.D.O. Pena, J. Gao, M. Ono, R.W. Lambert, R.S. Kelleher, and D.A. Sullivan, Influence of gender and the endocrine environment on the distribution of androgen receptors in the lacrimal gland. J. Steroid Biochem. Mol. Biol. 46:737 (1993).

    Article  PubMed  CAS  Google Scholar 

  45. J. Gao, R.W. Lambert, and D.A. Sullivan, Endocrine control of secretory component mRNA levels in the rat lacrimal gland, Invest. Ophthalmol. Vis. Sci. Suppl. 34:1485 (1993).

    Google Scholar 

  46. L. Danel, M. Menouni, J. Cohen, J. Magaud, G. Lenoir, J. Revillard, and S. Saez, Distribution of andro-gen and estrogen receptors among lymphoid and haemopoietic cell lines, Leukemia Res. 9:1373 (1985).

    Article  CAS  Google Scholar 

  47. S.A. Robertson, M. Brannstrom, and R.F. Seamark, Cytokines in rodent reproduction and the cytokine-endocrine interaction, Curr. Opin. Rheumatol. 4:585 (1992).

    CAS  Google Scholar 

  48. A.L. Jacobs, P.B. Sehgal, J. Julian, and D.D. Carson, Secretion and hormonal regulation of interleukin-6 production by mouse uterine stromal and polarized epithelial cells cultured in vitro, Endocrinology 131:1037 (1992).

    Article  PubMed  CAS  Google Scholar 

  49. S. Suemori, C. Ciacci, and D.K. Podolsky, Regulation of transforming growth factor expression in rat intestinal epithelial cells, J. Clin. Invest. 87:2216 (1991).

    Article  PubMed  CAS  Google Scholar 

  50. D.W. McGee, K.W. Beagley, W.K. Aicher, and J.R. McGhee, Transforming growth factor-b and IL-1b act in synergy to enhance IL-6 secretion by the intestinal epithelial cell line, IEC-, J. Immunol. 151:970 (1993).

    PubMed  CAS  Google Scholar 

  51. S.S. Chen, and Q. Li, Transforming growth factor-b1 (TGF-b1) is a bifunctional immune regulator for mucosal IgA responses, Cell. Immunol. 128:353 (1990).

    Article  PubMed  CAS  Google Scholar 

  52. J.R. McGhee, J. Mestecky, C.O. Elson, and H. Kiyono, Regulation of IgA synthesis and immune response by T cells and interleukins, J. Clin. Immunol. 9:175 (1989).

    Article  PubMed  CAS  Google Scholar 

  53. M. Ono, Z. Huang, L.A. Wickham, J. Gao, and D.A. Sullivan, Analysis of androgen receptors and cytokines in lacrimal glands of a mouse model of Sjogren’s syndrome. Invest .Ophthalmol. Vis. Sci. Suppl., in press (1994).

    Google Scholar 

  54. D.W. McGee, W.A. Aicher, J.H. Eldridge, J.V. Peppard, J. Mestecky, and J.R. McGhee, Transforming growth factor-b enhances secretory component and major histocompatibility complex class I antigen expression on rat IEC-6 intestinal epithelial cells, Cytokine 3:543 (1991).

    Article  PubMed  CAS  Google Scholar 

  55. J.P. Whitcher, Clinical diagnosis of the dry eye, Internat. Ophthalmol. Clin. 27:7 (1987).

    Article  CAS  Google Scholar 

  56. R.I. Fox, ed., “Sjogren’s Syndrome,” Rheum. Dis. Clin. NA. vol. 18 (3) (1992).

    Google Scholar 

  57. K.F. Tabbara, Sjogren’s Syndrome, in: “The Cornea. Scientific Foundations and Clinical Practice,” G. Smolin, and R.A. Thoft, eds., Little, Brown and Co, Boston, MA, pp 309–314 (1983).

    Google Scholar 

  58. M.C. Kincaid, The eye in Sjogren’s syndrome, in: “Sjogren’s Syndrome. Clinical and Immunological Aspects,” N. Talal, H.M. Moutsopoulos, and S.S. Kassan SS, eds., Springer Verlag, Berlin, pp 25–33 (1987).

    Google Scholar 

  59. S.A. Ahmed, T.B. Aufdemorte, J.R. Chen, A.I. Montoya, D. Olive, and N. Talal, Estrogen induces the development of autoantibodies and promotes salivary gland lymphoid infiltrates in normal mice, J. Autoimmunity 2:543 (1989).

    Article  CAS  Google Scholar 

  60. H. Carlsten, A. Tarkowski, R. Holmdahl, and L.A. Nilsson, Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice, Clin. exp. Immunol. 80:467 (1990).

    Article  PubMed  CAS  Google Scholar 

  61. R. McMurray, D. Keisler, K. Kanuckel, S. Izui, and S.E. Walker, Prolactin influences autoimmune disease activity in the female B/W mouse. J. Immunol. 147:3780 (1991).

    PubMed  CAS  Google Scholar 

  62. H. Ariga, J. Edwards, and D.A. Sullivan, Androgen control of autoimmune expression in lacrimal glands of MRL/Mp-lpr/lpr mice, Clin. Immunol. Immunopath. 53:499 (1989).

    Article  CAS  Google Scholar 

  63. A.C. Vendramini, C.H. Soo, and D.A. Sullivan, Testosterone-induced suppression of autoimmune disease in lacrimal tissue of a mouse model (NZB/NZW Fl) of Sjogren’s syndrome, Invest. Ophthalmol. Vis. Sci. 32:3002 (1991).

    PubMed  CAS  Google Scholar 

  64. E.H. Sato, H. Ariga H, and D.A. Sullivan, Impact of androgen therapy in Sjogren’s syndrome: Hormonal influence on lymphocyte populations and Ia expression in lacrimal glands of MRL/Mp-lpr/lpr mice, Invest. Ophthalmol. Vis. Sci. 33:2537 (1992).

    PubMed  CAS  Google Scholar 

  65. E.H. Sato, and D.A. Sullivan, Comparative influence of steroid hormones and immunosuppressive agents on autoimmune expression in lacrimal glands of a female mouse model (MRL/Mp-lpr/lpr) of Sjogren’s syndrome, Invest. Ophthalmol. Vis. Sci., in press (1994).

    Google Scholar 

  66. M. Appelmans, La Keratoconjonctivite seche de Gougerot-Sjogren, Arch. ’Ophtalmologie 81:577 (1948).

    Google Scholar 

  67. R. Bruckner, Uber einem erfolgreich mit perandren behandelten fall von Sjogren’schem Symptomen komplex, Ophthalmologica 110:37 (1945).

    Article  PubMed  CAS  Google Scholar 

  68. A. Bizzarro,G. Valentini, G. Di Marinto, A. Daponte, A. De Bellis, and G. Iacono, Influence of testosterone therapy on clinincal and immunological features of autoimmune diseases associated with Klinefelter’s syndrome, J. Clin. End. Metab. 64:32 (1987).

    Article  Google Scholar 

  69. F.J. Rocha, E.H. Sato, B.D., Sullivan, and D.A. Sullivan, Comparative efficacy of androgen analogues in suppressing lacrimal gland inflammation in a mouse model (mRL/lpr) of Sjogren’s syndrome, in: “Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance,” D.A. Sullivan, B.B. Bromberg, M.M. Cripps, D.A. Dartt, D.L. MacKeen, A.K. Mircheff, P.C. Montgomery, K. Tsubota, and B. Walcott, eds., Adv. Exp. Med. Biol., in press (1994).

    Google Scholar 

  70. C. Lavalle, E. Loyo, R. Paniagua, JA. Bermudez, J. Herrera, A. Graef, D. Gonzalez-Barcena, and A. Fraga, Correlation study between prolactin and androgens in male patients with Systemic Lupus Erythematosus, J. Rheum. 14:268 (1987).

    PubMed  CAS  Google Scholar 

  71. R.G. Lahita, The importance of estrogens in SLE, Clin. Immunol. Immunopath. 63:17 (1992).

    Article  CAS  Google Scholar 

  72. R.G. Lahita, H.L. Bradlow, E. Ginzler, S. Pang, and M. New, Low plasma androgens in women with systemic lupus erythematosus, Arth. Rheum. 30:241 (1987).

    Article  CAS  Google Scholar 

  73. J. Comsa, H. Leonhardt, and H. Wekerle H, Hormonal coordination of the immune response, Rev. Physiol. Biochem. Pharmacol. 92:115 (1982).

    Article  PubMed  CAS  Google Scholar 

  74. D. Eidenger, and T.J. Garrett, Studies of the regulatory effects of the sex hormones on antibody formation and stem cell differentiation, J. Exp. Med. 136:1098 (1972).

    Article  Google Scholar 

  75. Y. Lebranchu, P. Bardos, and M.A. Bach, Thymic function in NZB mice. IV. Role of thymus secretion and sex factors in the expression of suppression, Clin. Immunol. Immunopathol. 23:563 (1982).

    Article  PubMed  CAS  Google Scholar 

  76. J.R. Roubinian, N. Talal, J.S. Greenspan, J.R. Goodman, and P.K. Siiteri, Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW Fl mice, J. Exp. Med. 147:1568 (1978).

    Article  PubMed  CAS  Google Scholar 

  77. N. Talal, and S.A. Ahmed, Sex hormones and autoimmune disease, Int. J. Immunotherapy 3:65 (1987).

    CAS  Google Scholar 

  78. W. Savino, E. Bartoccioni, F. Homo-Delarche, M. Gagnerault, T. Itoh, and M. Dardenne, Thymic hormone containing cells-IX. Steroids in vitro modulate thymulin secretion by human and murine thymic epithelial cells, J. Steroid. Biochem. 30:479 (1988).

    Article  PubMed  CAS  Google Scholar 

  79. E.J. Goldsteyn, and M.J.L. Fritzler, The role of the thymus-hypothalamus-pituitary-gonadal axis in normal immune processes and autoimmunity, J. Rheumatol. 14:982 (1987).

    Google Scholar 

  80. C.J. Grossman, Are there underlying immune-neuroendocrine interactions responsible for immunological sexual dimorphism?, Prog. Neuro Endocrin Immunology 3:75 (1990).

    Google Scholar 

  81. N.J. Olsen, M.B. Watson, and W.J. Kovacs, Studies of immunological function in mice with defective androgen action. Distinction between alterations in immune function due to hormonal insensitivity and alteration due to other genetic factors, Immunology 73:52 (1991).

    PubMed  CAS  Google Scholar 

  82. Y. Weinstein, and Z. Berkovich, Testosterone effect on bone marrow, thymus and suppressor T cells in the (NZB/NZW) Fl mice: its relevance to autoimmunity, J. Immunol. 126:998 (1981).

    PubMed  CAS  Google Scholar 

  83. KA. Melez, W.A. Boegel, and A.D. Steinberg, Therapeutic studies in New Zealand mice. VII. Successful androgen treatment of NZB/NZW Fl females of different ages, Arthritis Rheum. 23:41 (1980).

    Article  PubMed  CAS  Google Scholar 

  84. N. Talal, H. Dang, S.A. Ahmed, E. Kraig, and M. Fischbach, Interleukin 2, T cell receptor and sex hormone studies in autoimmune mice, J. Rheum. (suppl. 13) 14:21 (1987).

    Google Scholar 

  85. S.A. Ahmed, W.J. Penhale, and N. Talal, Sex hormones, immune responses and autoimmune diseases, Am. J. Pathol. 121:531 (1985).

    CAS  Google Scholar 

  86. J.P. Michalski, C.C. McCombs, J.R. Roubinian, and N. Talal, Effect of androgen therapy on survival and suppressor cell activity in aged NZB/NZW Fl mice, Clin. exp. Immunol. 52,229 (1983).

    PubMed  CAS  Google Scholar 

  87. G. Holdstock, B.F. Chastenay, and E.L. Krawitt, Effects of testosterone, oestradiol and progesterone on immune regulation, Clin. exp. Immunol. 47:449 (1982).

    PubMed  CAS  Google Scholar 

  88. J.B. Allen, D. Blatter, G.B. Calandra, and R.L. Wilder, Sex hormonal effects on the severity of streptococcal cell wall-induced polyarthritis in the rat, Arthritis Rheum. 26:560 (1983).

    Article  PubMed  CAS  Google Scholar 

  89. S.A. Ahmed, M.J. Dauphinee, and N. Talal, Effects of short-term administration of sex hormones on normal and autoimmune mice, J. Immunol. 134:204 (1985).

    CAS  Google Scholar 

  90. N. Talal, S.A. Ahmed, and M. Dauphinee, Hormonal approaches to immunotherapy of autoimmune diseases, N.Y. Acad. Sci. 475:320 (1986).

    Article  CAS  Google Scholar 

  91. S.A. Ahmed, P.R. Young, and W.J. Penhale, Beneficial effect of testosterone in the treatment of chronic autoimmune thyroiditis in rats, J. Immunol. 136:143 (1986).

    CAS  Google Scholar 

  92. A.D. Steinberg, J.B. Roths, E.D. Murphy, R.T. Steinberg RT, and E.S. Raveche, Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice, J. Immunol. 125:871 (1980).

    PubMed  CAS  Google Scholar 

  93. H. Carlsten, R. Holmdahl, A. Tarkowski, and L.A. Nilsson, Oestradiol- and testosterone-mediated effects on the immune system in normal and autoimmune mice are genetically linked and inherited as dominant traits, Immunology 68:209 (1989).

    PubMed  CAS  Google Scholar 

  94. J.I. Morton, D.A. Weyant, B.V. Siegel, and B.L. Golding, Androgen sensitivity and autoimmune disease. I. Influence of sex and testosterone on the humoral immune response of autoimmune and non-autoimmune mouse strains to sheep erythrocytes, Immunology 44:661 (1981).

    PubMed  CAS  Google Scholar 

  95. J.E. Brick, D.A. Wilson, and S.E. Walker, Hormonal modulation of responses to thymus-independent and thymus-dependent antigens in autoimmune NZB/W mice, J. Immunol 134:3693 (1985).

    PubMed  CAS  Google Scholar 

  96. J.E. Brick, S.E. Walker, and K.S. Wise, Hormone control of autoantibodies to calf thymus nuclear extract (CTE) and DNA in MRL-lpr and MRL-+/+ mice, Clin. Immunol. Immunopathol. 46:68 (1988).

    Article  PubMed  CAS  Google Scholar 

  97. Z.M. Sthoeger, N. Chiorazzi, and R.G. Lahita, Regulation of the immune response by sex hormones. I. In vivo effects of estradiol and testosterone on pokeweed-mitogen-induced human B-cell differentiation, J. Immunol. 141:91 (1988).

    PubMed  CAS  Google Scholar 

  98. M. Ono, F.J. Rocha, E.H. Sato, and D.A. Sullivan, Distribution and endocrine regulation of androgen receptors in lacrimal glands of the MRL/lpr mouse model of Sjogren’s syndrome, in: “Proceedings of the IVth International Symposium on Sjgren’s Syndrome,” Kluger Press, Amsterdam, in press (1994).

    Google Scholar 

  99. D.A. Sullivan, H. Ariga, A.C. Vendramini, F.J. Rocha, and E.H. Sato EH, Androgen-induced suppression of autoimmune disease in lacrimal glands of mouse models of Sjogren’s syndrome, in: “Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance,” D.A. Sullivan, B.B. Bromberg, M.M. Cripps, D.A. Dartt, D.L. MacKeen, A.K. Mircheff, P.C. Montgomery, K. Tsubota, and B. Walcott, eds., Adv. Exp. Med. Biol., in press (1994).

    Chapter  Google Scholar 

  100. R.I. Fox, and I. Saito, Sjogren’s syndrome: immunologic and neuroendocrine mechanisms, in: “Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance,” D.A. Sullivan, B.B. Bromberg, M.M. Cripps, D.A. Dartt, D.L. MacKeen, A.K. Mircheff, P.C. Montgomery, K. Tsubota, and B. Walcott, eds., Adv. Exp. Med. Biol., in press (1994).

    Google Scholar 

  101. H. Dang, K. Lazaridis, T. Aufdemorte, H. McGuff, and N. Talal, PCR analysis of cytokines produced in salivary glands of Sjogren’s syndrome, in: “Proceedings of the IVth International Symposium on Sjogren’s Syndrome,” Kluger Press, Amsterdam, in press (1994).

    Google Scholar 

  102. M.M. Shull, I. Ormsby, A.B. Kier, S. Pawlowski, R.J. Diebold, M. Yin, R. Allen, C. Sidman, G. Proetzel, D. Calvin, N. Annunziata, and T. Doetschman, Targeted disruption of the mouse transforming growth factor-b1 gene results in multifocal inflammatory disease, Nature 359:693 (1992).

    Article  PubMed  CAS  Google Scholar 

  103. E. Nagy, I. Berczi, and E. Sabbadini, Endocrine control of the immunosuppressive activity of the submandibular gland, Brain Beh. Imm. 6:418 (1992).

    Article  CAS  Google Scholar 

  104. J. Krueger, A. Ray, I. Tamm, and P.B. Sehgal, Expression and function of interleukin-6 in epithelial cells, J. Ceil. Biochem. 45:327 (1991).

    Article  CAS  Google Scholar 

  105. M. De, T.R. Sanford, and G.W. Wood, Interleukin-1, interleukin-6, and tumor necrosis factor a are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone, Dev. Biol. 151:297 (1992).

    Article  PubMed  CAS  Google Scholar 

  106. N. Sarvetnick, and H.S. Fox, Interferon-gamma and the sexual dimorphism of autoimmunity, Mol. Biol. Med. 7:323 (1990).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Harvard Medical School, USA

    David A. Sullivan, Zhiyan Huang, Ross W. Lambert, L. Alexandra Wickham, Masafumi Ono, Janethe D. O. Pena & Jianping Gao

  2. Schepens Eye Research Institute, 20 Staniford Street, Boston, MA, 02114, USA

    David A. Sullivan, Zhiyan Huang, Ross W. Lambert, L. Alexandra Wickham, Masafumi Ono, Janethe D. O. Pena & Jianping Gao

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  1. David A. Sullivan
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  2. Zhiyan Huang
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Editors and Affiliations

  1. Department of Immunology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Istvan Berczi

  2. National Institute of Haematology, Blood Transfusion and Immunology, Budapest, Hungary

    Judith Szélenyi

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Sullivan, D.A. et al. (1994). Androgen Regulation of Ocular Mucosal- and Auto-Immunity. In: Berczi, I., Szélenyi, J. (eds) Advances in Psychoneuroimmunology. Hans Selye Symposia on Neuroendocrinology and Stress, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9104-4_17

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  • DOI: https://doi.org/10.1007/978-1-4757-9104-4_17

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