Interleukin Involvement in the Regulation of Pituitary Cell Growth

  • E. Arzt
  • J. Sauer
  • U. Renner
  • G. K. Stalla
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)


After the first description by Besedovsky et al.1 of the stimulatory action of interleukin-1 (IL-1) on the secretion of hormones by the hypothalamic-pituitary-adrenocortical (HPA) axis, the action of this and other cytokines have been extensively studied. IL-1 is the most potent cytokine stimulating the axis. As we will concentrate on other aspects of cytokine action, it is beyond the scope of this chapter to review the action of cytokines on hormone secretion. It is now well accepted that these cytokines not only constitute a lymphocyte message but also that they are autocrine and paracrine factors in the regulation of the HPA axis, especially the pituitary. We will start with a brief description about the intrinsic expression of interleukins and their receptors on neuro-endorine tissues and then concentrate on their effects on the growth of these cells.


Pituitary Adenoma Pituitary Cell Anterior Pituitary Cell Pituitary Carcinoma Human Pituitary Adenoma 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • E. Arzt
    • 1
  • J. Sauer
    • 1
  • U. Renner
    • 1
  • G. K. Stalla
    • 1
  1. 1.Clinical InstituteMax-Planck-Institute of PsychiatryMunichGermany

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