Abstract
Ventricular fibrillation (VF) is the malignant electrical rhythm of the heart. Fundamental understanding of this rhythm can only be obtained by considering signals generated by single heart cells, isolated heart tissue, and the whole organ. Interpretation of these complex phenomena also requires that we employ the modern signal processing methods that consider the temporal, spectral and dynamical features of this rhythm. We recorded action potentials (AP) from single cells in isolated fibrillating hearts with the aid of a floating microelectrode technique, and in cardiac tissue using optical fluorescence imaging. 1) Time-frequency analysis of these signals reveals different characteristics of VF signal during early and late stages of fibrillation. Perfusion of the heart maximized the short-term, high-frequency events, while without perfusion, the time-frequency distributions showed dispersion. Time-frequency analysis was thus shown to be helpful in characterizing AP during various stages of VF. 2) Parametric modeling was next considered to determine the evolution of fibrillation with extended periods of time, a situation that would arise during resuscitation procedures. Autoregressive modeling of VF signals was carried out to identify changes in the dominant poles of the VF signals with time course of evolution of VF. Parametric modeling of VF was thus shown to be useful in predicting the duration of cardiac arrest. 3) Finally, we sought to determine how dynamics of VF signals change with time, and in particular whether fibrillation can be considered chaotic at the cellular levels. Dynamical analysis, carried out by the methods of dimensional analysis and Lyapunov exponents revealed that VF has a relatively low dimensional attractor at the single cell level even though VF on the heart or the body surface may be a high dimensional process. Such analyses may help suggest methods to track and modify low dimensional chaotic VF in its early stages of evolution. 4) Finally, algorithms were developed for application in a clinical device such as the implantable cardioverter-defibrillator. Here, the emphasis is on the reducing false positive and false negative rates. This objective is accomplished using a sequential hypothesis testing algorithm that trades off accuracy for detection time and vice versa. In summary, non-parametric, parametric, and dynamical methods together provide quantitative insights into the fibrillation phenomenon at the cellular and whole heart levels, and may help in discrimination of various stages and forms of VF for the purposes of possible therapy.
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References
Arnsdorf, M. F., 1990. The cellular basis of cardiac arrhythmias. A matrical perspective, Annals N. Y Acad. Sci., 601: 263–280.
do Bakker, J. M. T., van Capelle, F. J. L., Janse, M. J., Wilde, A. A. M., Coronel, R., Becker, A. E., Dingemans, K. P., van Herne!, N. M., and R. N. W. Hauer, 1988. Reentry as a cause of ventricular tachycardia in patients with chronic ischemic heart disease: Electrophysiologic and anatomic correlation, Circulation 77: 589–606.
Bernstein, R. C., and Frame. L. H., Ventricular reentry around a fixed barrier. Resetting with advancement in an ìn vitro model, Circulation 81: 267–280.
Panflov, A. V., and Keener, J. P.. 1993, Generation of reentry in anisotropic myocardium../ Cardiovasc. Electrophysiol. 4: 412–421.
Moe. G. K., 1962. On the multiple wavelet hypothesis of atrial fibrillation, Archives Int. Pharmacodynamics 140: 183–188.
Kaplan, D. T., and Cohen, R. J., 1990, Is fibrillation chaos?, Cire. Res. 67: 886–892.
Goldberger, A. L.. and Rigney, D. R., 1988, Sudden death is not chaos, In: Dynamic Patterns in Complex Systems, Kelso, J. A. S., Mandell, A. J., Shlusinger, M. F., (ed.), World Scientific Publ: Singapore, pp. 248–264.
Hodgson, D., 1991, Electrophysiology of ventricular fibrillation studied by the microelectrode method, M.S.E. Dissertation, Johns Hopkins University, Baltimore, MD.
Hodgson, D., Fishier, M. G., Chan, R., and Thakor, N. V., 1992, Intracellular recordings during VF: role of ion channels from experiments and comptuter models, Proc. Comput. Cardiol., IEEE Comput. Soc. Press, pp. 537–540.
Carlisle, E. J. F., Allen, J. D., Bailey, A., et. al., 1988, Fourier analysis of ventricular fibrillation and synchronization of DC countershocks in defibrillation, J. Electrocardiol., 21: 337.
Baykal, A., Ranjan, R., and Thakor, N. V., 1996, Estimation of ventricular fibrillation duration by autoregressive modeling, IEEE Trans. Biomed. Eng.,in press.
Ideker, R. E., Klein, G. J., Harrison, L., Smith. W. M., Kassel, J., Reimer, K. A., Wallace, A. G., and Gallagher, J. J., 1981. The transition of ventricular fibrillation induced by reperfusion following acute ischemia in the dog, Circulation 63: 1371–1379.
El-Sherif, N.. 1985, The Figure 8 model of reentrant excitation in the canine postinfarction model, In: Cardiac Electrophysiology and Arrhythmias, Zipes D.P., Jalife J, (eds.), Gnme Stratton: Orlando, pp. 363–378.
Allessie, M. A., Bonke, F. I. M., and Schopman, F. J. G., 1977, Interactions across an inexcitable region as a cause of ectopie activity in acute regional myocardial ischemia. A study in intact porcine and canine hearts and computer models, Circ. Res. 50: 527–537.
Dzwonczyk, R., Brown, C. G., and Werma, H. A., 1990, The median frequency of the ECG during ventricular fibrillation: Its use in an algorithm for estimating the duration of cardiac arrest, IEE Trans. Biomed. Eng. 37: 640–645.
Akiyama, T. 1981, Intracellular recording of in situ ventricular cells during ventricular fibrillation, Am. J. Physiol. 240: H465 - H471.
Allessie, M. A., Schatij, M. J., Kirchhof, C. J., Boersma, L., Huyberts, M.and Hollen, J., 1990, Electrophysiology of spiral waves in two dimensions: the role of anisotropy, Annals N.Y Acad. Sci. 591: 247–256.
Davidenko, J. M., Pertsov, A. V., Salomonsz, R., Baxter, W., and Jalife, J., 1992. Stationary and drifting spiral waves of excitation in isolated cardiac muscle, Nature 355: 349–351.
Dillon, S., and Morad, M., 1981, A new laser scanning system for measuring action potential propagation in the heart, Science 214: 453–456.
Efimov, I. R., Huang, D. T., and Salama, G., 1994, Optical mapping of repolarization and refractoriness from intact hearts, Circulation 90: 1469–1480.
Knisley, S. B., Blitchington, T. F., Hill, B. C., Grant, A. O., Smith, W. M., Pilkington, T. C., and Ideker, R. E., 1993, Optical measurements of transmembrane potential changes during electric field stimulation of ventricular cells, Cire. Res. 72: 255–270.
Dzwonczyk, R., Brown, C. G., and Verma, H. A., 1990, The median frequency of the ECG during ventricular fibrillation: its use in an algorithm for estimating the duration of cardiac arrest, IEEE Trans. Biomed. Eng. 37: 640–646.
Camm, A. J., Davies, D. W., and Ward, D. E., 1987, Tachycardia recognition by implantable electronic devices, PACE Pacing Clin. Electrophysiol. 10: 1175–1190.
Geselowitz, D. B., Smith, S., Mowrey, K., and Berbari. E. J.. 1991, Model studies of extracellular electrograms arising from an excitation wave propagating in a thin layer. IEEE Trans. Biomed. Eng. 38: 526–531.
Greenhut, S. E., Dicarlo, L. A., Jenkins, J. M., Throne, R. D. and Winston, S. A., 1991, Identification of ventricular tachycardia using intracardiac electrograms: a comparison of unipolar versus bipolar waveform analysis, PACE Pacing Clin. Electrophysiol. 14: 427–433.
Lin, D., DiCarlo, L. A. and Jenkins, J. M. 1988, Identification of ventricular tachycardia using intracavitary electrograms: analysis of time and frequency domain patterns, PACE 11: 41–249.
Throne, R. D., Jenkins, J. M., and DiCarlo, L. A.. 1990. Intraventricular electrogram analysis for ventricular tachycardia detection: statistical validation, PACE Pacing Clin. Electrophysiol. 13: 15961601.
Chen, S., Thakor, N. V., and Mower, M. M., 1987, Ventricular fibrillation detection by a regression test on the autocorrelation function, Med. Biol. Eng. Comput. 25: 241–249.
Steinhaus, B. M., Wells, R. T., Greenhut, S. E., Maas, S. M., Nappholz, T. A., Jenkins, J. M.. and DiCarlo, L. A., 1990, Detection of ventricular tachycardia using scanning correlation analysis, PACE. Pacing Clin. Electrophysiol. 13: 1930–1936.
Nygards, M., and Hutting, J., 1977, Recognition of ventricular fibrillation utilizing the power spectrum of the ECG, Proc. Comput. Cardiol., IEEE Comput. Soc. Press, pp. 393–397.
Babloyantz, A. and Destexhe, A., 1988, Is the normal heart a periodic oscillator? Biol. Cybernetics 58: 203–211.
Casaleggio, A., Ranjan, R., and Thakor, N. V., 1994, Correlation dimension analysis of epicardial cell action potentials during different cardiac arrhythmias, Proc. Comput. Cardiol., IEEE Comput. Soc. Press, pp. 697–700.
Russel, D. C., Smith, H. J., and Oliver, M. F., 1979, Transmembrane potential changes and ventricular fibrillation during repetitive myocardial ischemia in the dog, Br. Heart J. 42: 88–96.
Hogancamp, C. E., Kardech, M., Danforth, W. H., and Bing, R. J., 1959, Transmembrane electrical potentials in ventricular tachycardia and fibrillation, Am. Heart J. 57: 214–222.
Joyner, R. W., Picone, J., Veenstra, R., and Rawling, D., 1983, Propagation through electrically coupled cells. Effects of regional changes in membrane properties, Circ. Res. 53: 526–534.
Morkrid, L., Ohm, O. J., and Engedal, H., 1984, Time domain and spectral analysis of electrograms in man during regular ventricular activity and ventricular fibrillation, IEEE Trans. Biomed. Eng. 31: 350–355.
Cohen, L., 1989, Time-frequency distributions: a review, Proc. IEEE 77: 941–981.
Boashash, B., 1992, Time-Frequency Signal Analysis: Methods and Applications, Australia: Longman Cheshire.
Yi-Sheng, Z., Bin, Z., and Thakor, N. V., 1996, Variable convergence adaptive filter and its application to cardiac action potential, Med. Biol. Eng. Comput.,in press.
Thakor, N. V., and Yi-Sheng, Z., 1991, Some applications of adaptive filtering to ECG analysis: noise cancellation and arrhythmia detection, IEEE Trans. Biomed. Eng. 38: 785–794.
Laguna, P., Jane, R., Meste, O., Poon, P., Caminal, P., Rix, H., and Thakor, N. V., 1992, Adaptive filter for event-related bioelectric signals using an impulse correlated reference input: comparison with signal averaging techniques, IEEE Trans. Biomed. Eng. 39: 1032–1044.
Spach, M. S., Miller III, W. T., MillerPJones, E., Warren, R. B., 1979, Extracellular potentials related to intracellular action potentials during impulse conduction in anisotropic canine cardiac muscle. Circ. Res. 45: 188–204.
Baykal, A.. Ranjan, R., and Thakor, N. V., 1994, Model based analysis of ECG during early stages of ventricular fibrillation, J. Electrocardiol. 27 (suppl.): 84–90.
Kaplan, D., Smith, J., Saxberg, B., and Cohen, R., 1988, Nonlinear dynamics in cardiac conduction, Math. Biosci. 90: 19–48.
Parker,T. S., and Chua, L. O. 1987, Chaos: a tutorial for engineers, Proc. IEEE 75: 982–1008.
Casaleggio, A., Ranjan, R., and Thakor, N. V., 1996, Dimensional analysis of the electrical activity at the epicardium of isolated hearts. Int. J. Bifurc. Chaos, to be published.
Jenkins. J., Bump, T., and Mukenbeck, F., 1984, Tachycardia detection in implantable antitachycardia devices, PACE Pacing Clin. Electrophysiol. 7: 1273–1277.
Khoury, D. S., and Wilkoff, B. L., 1990, Tachycardia recognition algorithms for implantable systems, IEEE Eng. Med. Biol. Mag. 9: 40–42.
Ropella, K. M., Baerman, J. M., Sahakian, A. V.. and Swiryn, S., 1990, Differentiation of ventricular tachyarrhythmias, Circulation 82: 2035–2043.
Thakor, N. V., Zhu, Y. S., and Pan, K. Y., 1990, Ventricular tachycardia and fibrillation detection by a sequential hypothesis testing algorithm, IEEE Trans. Biomed. Eng. 37: 837–843.
DiCarlo, L. A., Throne, R. D., and Jenkins, J. M., 1991, A time-domain analysis of intracardiac electrograms for arrhythmia detection, PACE Pacing Clin. Electrophysiol. 14: 329–336.
Shoupu, C., Thakor, N. V., and Mower, M. M., 1987, Ventricular fibrillation detection by regression test of autocorrelation function, Med. Biol. Eng. Comput. 25: 241–249.
Thakor, N. V. and Pan, K., 1990, Tachycardia and Fibrillation Detection by Automatic Implantable Cardioverter-Defibrillators: Sequential Testing in the Time Domain, IEEE Eng. Med. Biol. Soc. Mag. 9: 21–24.
Thakor, N. V., Natarajan, A., and Tomaselli, G., 1994, Multiway sequential hypothesis testing for tachyarrhythmia discrimination, IEEE Trans. Biomed. Eng. 41: 480–487.
Fishier, M. G. and Thakor, N. V., 1991, massively parallel computer model of propagation through two dimensional cardiac syncytium, PACE Pacing Clin. Electrophysiol. 14 (Part II ): 1694–1699.
Mirowski, M.. and Mower. M. M., 1985, The automatic implantable defibrillator, Am. Heart J. 100: 996–1004.
Thakor, N. V., 1984, From Holter monitors to automatic defibrillators: developments in ambulatory arrhythmia monitoring, IEEE Trans. Biomed. Eng. 31: 700–708.
Fisher, J. D., Kim, S. G., and Mercando, A. D., 1988, Electrical devices for treatment of arrhythmias, Am. J. Cardiol. 61: 45a - 57a.
Casaleggio, A., 1993, Differences on the correlation dimension of MIT-BIH ECG database recordings, Proc. Comput. Cardiol., IEEE Comput. Soc. Press, pp. 539–542.
Ropella, K. M., A. V., M., Swiryn, S., 1989, The coherence spectrum. A quantitative discriminator of fibrillatory and nonfibrillatory cardiac rhythms, Circulation 80: 112–119.
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Thakor, N.V., Baykal, A., Casaleggio, A. (1996). Fundamental Analyses of Ventricular Fibrillation Signals by Parametric, Nonparametric, and Dynamical Methods. In: Gath, I., Inbar, G.F. (eds) Advances in Processing and Pattern Analysis of Biological Signals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9098-6_19
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DOI: https://doi.org/10.1007/978-1-4757-9098-6_19
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