Skip to main content
SpringerLink
Log in

The Significance of Habitual Calcium Intake in the Pathogenesis of Peri- and Early Postmenopausal Bone Loss

  • Chapter
Nutrition and Osteoporosis

Part of the book series: Advances in Nutritional Research ((ANUR,volume 9))

  • 204 Accesses

Abstract

The first hypothesis for the pathogenesis of postmenopausal osteoporosis was postulated by Albright and colleagues (1941). They suggested a cause and effect relationship between estrogen withdrawal and the occurrence of crush fractures of the vertebrae resulting from loss of bone. Since then ovarian failure has been considered to be the most important determinant of the accelerated bone loss in women during the early postmenopause, and the evidence that the adverse skeletal changes can be prevented with estrogen replacement therapy seems reasonably firm (Weiss et al.,1980; Kreiger et al.,1982; Ettinger et al.,1985).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albright, F., Smith, P.H., and Richardson, A.M., 1941, Postmenopausal osteoporosis; its clinical features, JAMA 116: 2465.

    Article  Google Scholar 

  • Beresteijn, E.C.H. van, and Hof, M.A. van’t, 1990, “Contributions of ovarian failure and aging to cortical bone loss in perimenopausal women: a mixed-longitudinal study” in: Osteoporosis 1990 ( Christiansen, C., and Overgaard, K., eds.), Handelsstrykkeriet Aalborg, Aalborg pp. 1023 - 1025.

    Google Scholar 

  • Beresteijn, E.C.H. van, Hof, M.A. van’t, Waard, H. de, Neeter, R., Winkeldermaat, H.J., Visser, R.M., Schaafsma, G., Schaik, M. van, and Duursma, S.A., 1986, Design and data quality of a mixed-longitudinal study to elucidate the role of dietary calcium and phosphorus on bone mineralization in pre-, peri-and postmenopausal women, Am. J. Clin. Nutr. 43: 538.

    Google Scholar 

  • Beresteijn, E.C.H. van, Hof, M.A. van’t, Schaafsma, G., Waard H. de, and Duursma, S.A., 1990a. Habitual dietary calcium intake and cortical bone loss in perimenopausal women: a longitudinal study, Calcif. Tissue Int. 47: 338.

    Article  Google Scholar 

  • Beresteijn, E.C.H. van, Hof, M.A. van’t, Waard, H. de, Raymakers, J.A., and Duursma, S.A., 1990b, Relation of axial bone mass to habitual calcium intake and to cortical bone loss in healthy early postmenopausal women, Bone 11: 7.

    Article  Google Scholar 

  • Beresteijn, E.C.H. van, Dekker, P.R., Heiden-Winkeldermaat, H.J. van der, Schaik, M. van, Visser, R.M., and Waard, H. de, 1991, “The habitual calcium intake from milk products and its significance for bone health; a longitudinal study,” in: Nutritional Aspects of Osteoporosis ( P. Burkhardt and R.P. Heaney, eds.), Raven Press, New York pp. 206 - 212.

    Google Scholar 

  • Cumming, R.G., 1990, Calcium intake and bone mass: A quantitative review of the evidence, Calcif. Tissue Int. 47: 194.

    Article  CAS  Google Scholar 

  • Davis, J.W., Ross, P.D., Wasnich, R.D., MacLean, C.J., and Vogel, J.M., 1991, Long-term precision of bone loss rate measurements among postmenopausal women, Calcif. Tissue Int. 48: 311.

    Article  CAS  Google Scholar 

  • Dawson-Hughes, B., 1991, Calcium supplementation and bone loss: a review of controlled clinical trials, Am. J. Clin. Nutr. 54: 274S.

    CAS  Google Scholar 

  • Dawson-Hughes, B., and Dallai, G.E., 1991, Effect of radiographic abnormalities on rates of bone loss from the spine, Calcif. Tissue Int. 46: 280.

    Article  Google Scholar 

  • Dawson-Hughes, B., Dallal, G.E., Kral, E.A., Sadowski, L., Sahyoun, N., and Tannenbaum, S., 1990, A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women, N. Engl. J. Med. 323: 878.

    Article  CAS  Google Scholar 

  • Elders, P.J.M., 1991, “The long-term effect of calcium supplementation on bone loss in perimenopausal women,” in: Perimenopausal Bone Loss, Thesis VU, University Press, Amsterdam pp. 107 - 123.

    Google Scholar 

  • Elders, P.J.M., Netelenbos, J.C., Lips, P., Ginkel, F.C. van, and Stelt, P.F. van der, 1988, Accelerated vertebral bone loss in relation to the menopause: a cross-sectional study on lumbar bone density in 286 women of 46 to 55 years of age, Bone Miner. 5: 11.

    Article  CAS  Google Scholar 

  • Elders, P.J.M., Netelenbos, J.C., Lips, P., Ginkel, F.C. van, Khoe, E., Leeuwenkamp, O.R., Hackeng, W.H.L., and Stelt, P.F. van der, 1991, Calcium supplementation reduces vertebral bone loss in perimenopausal women: a controlled trial in 248 women between 46 and 55 years of age, J. Clin. Endocrinol. Metab. 73: 533.

    Article  CAS  Google Scholar 

  • Ettinger, B., Genant, H.K., and Cann, C.E., 1985, Longterm estrogen therapy prevents bone loss and fracture, Ann. Intern. Med. 102: 319.

    Article  CAS  Google Scholar 

  • Falch, J.A., and Gautvik, K.M., 1988, A longitudinal study of pre-and postmenopausal changes in calcium metabolism, Bone 9: 15.

    Article  CAS  Google Scholar 

  • Falch J.A., and Sandvik, L., 1990, Perimenopausal bone loss: a 10-year prospective study, Bone 11: 425.

    Article  CAS  Google Scholar 

  • Falch, J.A., Oftebro, H., and Haug, E., 1987, Early postmenopausal bone loss is not associated with a decrease in circulating levels of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, or vitamin D-binding protein, J. Clin. Endocrinol. Metab. 64: 836.

    Article  CAS  Google Scholar 

  • Geusens, P., Dequeker, J., Verstraeten, A., and Nijs, J., 1986, Age-, sex-, and menopausal-related changes in vertebral and peripheral bone: a population study using dual and single photonabsorptiometry and radiogrammetry, J. Nucl. Med. 27: 1540.

    CAS  Google Scholar 

  • Hansen, T., Overgaard, K., Riis, B.J., and Christiansen, C., 1991, Potential risk factors for development of postmenopausal osteoporosis examined over a 12-year period, Osteoporosis Int. 1: 95.

    Article  CAS  Google Scholar 

  • Hansson. T., and Roos, B., 1986, Age changes in the bone mineral content of the lumbar spine in normal women, Calcif. Tissue Int. 38: 249.

    Google Scholar 

  • Harris, S., and Dawson-Hughes, B., 1992, Rates of change in bone mineral density of the spine, heel, femoral neck and radius in healthy postmenopausal women, Bone Miner. 17: 87.

    Article  CAS  Google Scholar 

  • Heaney, R.P., 1986a, En recherche de la difference (p # 0.05), Bone Miner. 1: 99.

    CAS  Google Scholar 

  • Heaney, R.P., 1986b, “Calcium, bone health, and osteoporosis,” in: Bone and Mineral Research 4 ( W.A. Peck, ed.), Elsevier, Amsterdam-New York-Oxford, pp. 255 - 301.

    Google Scholar 

  • Heaney, R.P., 1991, “Assessment and consistency of calcium intake,” in: Nutritional Aspectsof Osteoporosis ( P. Burckhardt, and R. P. Heaney, eds.), pp. 99 - 104, Raven Press, New York.

    Google Scholar 

  • Heaney, R.P., 1992, Calcium in the prevention and treatment of osteoporosis, J. Int. Med. 231: 169.

    Article  CAS  Google Scholar 

  • Heaney, R.P., Recker, R.R., and Saville, P.D., 1978, Menopausal changes in calcium performance balance, J. Lab. Med. 92: 953.

    CAS  Google Scholar 

  • Horst, R.L., Goff, J.P., and Reinhardt, T.A., 1990, Advancing age results in reduction of intestinal and bone 1,25-dihydroxyvitamin D receptor, Endocrinol. 126: 1053.

    Article  CAS  Google Scholar 

  • Kanis, J.A., 1984, Treatment of osteoporotic fracture, Lancet i: 27.

    Google Scholar 

  • Kanis, J.A., 1991, Calcium requirements for optimal skeletal health in women, Calcif. Tissue Int. 49: S33.

    Article  Google Scholar 

  • Kanis, J.A., and Passmore, R., 1989a, Calcium supplementation of the diet-I, Br. Med. J. 298: 137.

    Article  CAS  Google Scholar 

  • Kanis J.A., and Passmore, R., 1989b, Calcium supplementation of the diet-II, Br. Med. J. 298: 205.

    Article  CAS  Google Scholar 

  • Kreiger, N, Kelsey, J.L., Holford, T.R., and O’Connor, T., 1982, An epidemiologic study of hip fracture in postmenopausal women, Am. J. Epidemiol. 116: 141.

    CAS  Google Scholar 

  • Krqilner, B., 1982, Seasonal variation of lumbar spine mineral content in normal women, Calcif. Tissue Int. 35: 145.

    Article  Google Scholar 

  • Matkovic, V., Kostial, K., Simonovic, I., Buzina, R., Broderec, A., and Nordin, B.E.C., 1979, Bone status and fracture rates in two regions of Yugoslavia, Am. J. Clin. Nutr. 32: 540.

    CAS  Google Scholar 

  • Mazess, R.B., 1982, On aging bone loss, Clin. Orthop. 165: 239.

    Google Scholar 

  • National Institutes of Health, 1984, Osteoporosis: consensus conference, DAMA 254: 799.

    Google Scholar 

  • Nilas, L., and Christiansen, C., 1987, Bone mass and its relationship to age and the menopause, J. Clin. Endocrinol. Metab. 65: 697.

    Article  CAS  Google Scholar 

  • Nilas, L., and Christiansen, C., 1989, The pathophysiology of peri-and postmenopausal bone loss, Br. J. Obst. Gynaec. 96: 580.

    Article  CAS  Google Scholar 

  • Nordin, B.E.C., 1960, Osteomalacia, osteoporosis and calcium deficiency, Clin. Orthop. 17: 235.

    Google Scholar 

  • Nordin, B.E.C., and Heaney, R.P., 1990, Calcium supplementation of the diet: justified by present evidence, Br. Med. J. 300: 1056.

    Article  CAS  Google Scholar 

  • Nordin, B.E.C., Need, A.G., Chatterton, B.E., Horowitz, M., and Morris, H.A., 1990, The relative contributions of age and years since menopause to postmenopausal bone loss, J. Clin. Endocrinol. Metab. 70: 83.

    Article  CAS  Google Scholar 

  • Nordin, B.E.C., Need, A.G., Bridges, A., and Horowitz, M., 1992, Relative contributions of years since menopause, age, and weight to vertebral density in postmenopausal women, J. Clin. Endocrinol. Metab. 74: 20.

    Article  CAS  Google Scholar 

  • Recker, R.R., and Heaney, R.P., 1985, The effect of milk supplements on calcium metabolism and calcium balance, Am. J. Clin. Nutr. 41: 254.

    CAS  Google Scholar 

  • Richelson, L.S., Wahner, H.W., Melton, L.J., and Riggs, B.L., 1984, Relative contribution of aging and estrogen deficiency to postmenopausal bone loss, N. Engl. J. Med. 311: 1273.

    Article  CAS  Google Scholar 

  • Riggs, B.L., and Melton, L.J., 1986, Involutional osteoporosis, N. Eng. J. Med. 314: 1676.

    Article  CAS  Google Scholar 

  • Riggs, B.L., and Melton, L.J., 1990, Clinical heterogeneity of involutional osteoporosis: implications for preventive therapy, J. Clin. Endocrinol. Metab. 70: 1229.

    Article  CAS  Google Scholar 

  • Riggs, B.L., Wahner, H.W., Mazess, R.B., Offord, K.P., and Melton, L.J.,1981, Differential changes in bone mineral density of the appendicular and axial skeleton with aging and its relationship to spinal osteoporosis, J. Clin. Invest. 67: 328.

    Google Scholar 

  • Schaadt, P., and Bohr, H., 1988, Differential trends of age-related diminution of bone mineral content in the lumbar spine, femoral neck, and femoral shaft in women, Calcif. Tissue Int. 42: 71.

    Article  CAS  Google Scholar 

  • Stevenson, J.C., 1984, “Interrelation of oestrogen and the major calcium regulating hormones,” in: The Climacteric—an Update ( H. van Herendael, B. van Herendael, F.E. Riphagen, K. Goessens and H. van de Pas, eds.), MTP Press Ltd, Lancaster, pp. 199 - 206.

    Chapter  Google Scholar 

  • Stevenson, J.C., Lees, B., Devenport, M., Cust, M.P., and Ganger, K.F., 1989, Determinants of bone density in normal women: risk factors for future osteoporosis? Br. Med. J. 298: 924.

    Article  CAS  Google Scholar 

  • Weiss, N.S., Ure, C.I., Ballard, J.H., Williams, A.R., and Dating, J.R., 1980, Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen, N. Engl. J. Med. 303: 1195.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nutrition, Netherlands Institute for Dairy Research (NIZO), P.O. Box 20, 6710 BA, Ede, the Netherlands

    E. C. H. van Beresteijn

Authors
  1. E. C. H. van Beresteijn
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Nutritional Sciences, University of Guelph, N1G 2W1, Guelph, Ontario, Canada

    Harold H. Draper

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

van Beresteijn, E.C.H. (1994). The Significance of Habitual Calcium Intake in the Pathogenesis of Peri- and Early Postmenopausal Bone Loss. In: Draper, H.H. (eds) Nutrition and Osteoporosis. Advances in Nutritional Research, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9092-4_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9092-4_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9094-8

  • Online ISBN: 978-1-4757-9092-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation