Chemoreflex Effects of Low Dose Sevoflurane in Humans

  • Jaideep J. Pandit
  • Jocelyn Manning-Fox
  • Keith L. Dorrington
  • Peter A. Robbins
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 450)


Knill and co-workers6found that doses of 0.1 MAC of volatile anaesthetics reduced the sensitivity of the response to CO2. However, Knill assessed ventilatory responsiveness to CO2using Read’s rebreathing method. Berkenbosch et al. showed that Read’s method gave misleading results and argued in favour of a steady-state method to study ventilatory responses to CO 2 1 . Using the steady-state method, it has been found that 0.1 MAC halothane reduces the ventilation-CO2response slope by 30%2, while 0.17 MAC nitrous oxide has no effect4. Desflurane (0.1 MAC) also does not affect the response to CO 2 5 .


Ventilatory Response Minimum Alveolar Concen Sustained Hypoxia Acute Hypercapnia Peripheral Chemoreflex 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Jaideep J. Pandit
    • 1
    • 2
  • Jocelyn Manning-Fox
    • 1
    • 2
  • Keith L. Dorrington
    • 1
    • 2
  • Peter A. Robbins
    • 1
    • 2
  1. 1.University Laboratory of PhysiologyOxfordUK
  2. 2.University of OxfordOxfordUK

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