Abstract
In awake humans, acute isocapnic hypoxia causes a rapid increase in both ventilation and heart rate. Although the acute ventilatory response is mediated primarily through a stimulatory drive from the carotid body, the heart rate response is more complex. There is apparently a heart rate depressing drive arising from the carotid bodies (CB), and a stimulation arising from a central effect of hypoxia, stimulation from vagal reflexes from the increased pulmonary ventilation and perhaps an increased drive from the aortic bodies (see ref. 1 for a review).
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References
De Burch Daly, M. Interactions between respiration and circulation. In: Handbook of Physiology, Section 3, Vol II Control of Breathing, Part 2. Alfred P. Fishman ed. American Physiological Society. Bethesda, 1986.
Dahan, A., D. Ward, M. van den Elsen, J. Temp, and A. Berkenbosch. Influence of reduced carotid body drive during sustained hypoxia on hypoxic depression of ventilation in humans. J. Appl. Physiol. 81: 565–572, 1996.
Ward, D.S., and M. Nino. The effects of dopamine on the ventilatory response to sustained hypoxia in humans. In: Control of Breathing and its Modeling Perspective, edited by Y. Honda, Y. Miyamoto, K. Konno, and J.G. Widdicombe. New York: Plenum Press, 1992, p. 291–298.
Liados, F., and P. Zapata. Effects of dopamine analogues and antagonists on carotid body chemosensors in situ. J. Physiol. Lond. 274: 487–499, 1993
Nishino, T., and S. Lahiri. Effects of dopamine on chemoreflexes in breathing. J. Appl. Physiol. 50: 892–897, 1981.
Jenkins, J.S., C.P. Valcke, and D.S. Ward. A programmable system for acquisition and reduction of respiratory physiological data. Ann. Biomed. Eng. 17: 93–108, 1989.
Sato, F., M. Nishimura, T. Igarashi, M. Yamamoto, K. Miyamoto, Y. Kawakami. Effects of exercise and CO2 inhalation on intersubject variability in ventilatory and heart rate responses to progressive hypoxia. Eur. Respir. J. 9:960–967, 1996.
Gross, P.M., B.J. Whipp, J.T. Davidson, S.N. Koyal, and K. Wasserman. Role of the carotid bodies in the heart rate response to breath holding in man. J. Appl. Physiol. 41: 336–340, 1976.
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Dahan, A., Ward, D.S. (1998). Influence of Low Dose Dopamine on the Heart Rate and Ventilatory Responses to Sustained Isocapnic Hypoxia. In: Hughson, R.L., Cunningham, D.A., Duffin, J. (eds) Advances in Modeling and Control of Ventilation. Advances in Experimental Medicine and Biology, vol 450. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9077-1_28
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DOI: https://doi.org/10.1007/978-1-4757-9077-1_28
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