Influence of Low Dose Dopamine on the Heart Rate and Ventilatory Responses to Sustained Isocapnic Hypoxia

  • Albert Dahan
  • Denham S. Ward
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 450)


In awake humans, acute isocapnic hypoxia causes a rapid increase in both ventilation and heart rate. Although the acute ventilatory response is mediated primarily through a stimulatory drive from the carotid body, the heart rate response is more complex. There is apparently a heart rate depressing drive arising from the carotid bodies (CB), and a stimulation arising from a central effect of hypoxia, stimulation from vagal reflexes from the increased pulmonary ventilation and perhaps an increased drive from the aortic bodies (see ref. 1 for a review).


Carotid Body Heart Rate Response Ventilatory Response Central Hypoxia Sustained Hypoxia 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Albert Dahan
    • 1
  • Denham S. Ward
    • 2
  1. 1.Departments of Anesthesiology and PhysiologyLeiden University Medical CenterLeidenThe Netherlands
  2. 2.Department of Anesthesiology and Electrical Engineering, School of Medicine and DentistryUniversity of RochesterRochesterUK

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