Abstract
In general, the airway and pulmonary receptors can be divided into three groups: 1) slowly adapting pulmonary stretch receptors (PSRs); 2) rapidly adapting receptors (RARs); 3) receptors innervated by C-fibers. PSRs and RARs are mechanoreceptors, although RARs are also activated by many biological and chemical substances (3, 16, 17, 29). On the other hand, C-fibers are believed to be chemosensitive endings (2).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Armstrong, D.J., J.C. Luck and V.M. Martin. The effect of emboli upon intrapulmonary receptors in the cat. Respir. Physiol. 26:41–54, 1976.
Coleridge, J.C.G. and H.M. Coleridge. Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev. Physiol. Biochem. Pharmacol. 99:1–110, 1984.
Coleridge, H.M. and J.C.G. Coleridge. Reflexes evoked from tracheobronchial tree and lungs. In: Handbook of Physiology, Section 3: The Respiratory System, Vol. II: Control of Breathing, part 1, edited by N.S. Cheniack and J.G. Widdicombe. Washington, D.C.: American Physiological Society, pp. 395–429, 1986.
Coleridge, H.M., J.C.G. Coleridge, and H.D. Schultz. Afferent pathways involved in reflex regulation of airway smooth muscle. Pharmac. Then 42:1–63, 1989.
Coleridge, H.M. and J.C.G. Coleridge. Pulmonary reflexes: neural mechanisms of pulmonary defense. Annu. Rev. Physiol. 56: 69–91, 1994.
Davies, R.O. and L. Kubin: Projection of pulmonary rapidly adapting receptors to the medulla of the cat: An antidromic mapping study. J. Physiol. 373: 63–86, 1986.
DeKock, M.A., J.A. Nadel, S. Zwi, H.J.H. Colebatch, and CR. Olsen: New method for perfusing bronchial arteries: histamine bronchoconstriction and apnea. J. Appl. Physiol. 21: 185–194, 1966.
Fuller, R.W. and J.G. Collier: Sodium cromoglycate and atropine block the fall in FEV, but not the cough induced by hypotonic mist. Thorax 39: 766–770, 1984.
Gold, W.M., G.-F. Kessler, and D.Y.C. Yu: Role of vagus nerves in experimental asthma in allergic dogs. J. Appl. Phsyiol. 33: 719–725, 1972.
Kappagoda, CT., G.C. Man, K. Ravi, and K.K. Teo: Reflex tracheal contraction during pulmonary venous congestion in the dog. J. Physiol. Lond. 402: 335–346, 1988.
Karczewski, W., and J.G. Widdicombe: The role of the vagus nerves in the respiratory and circulatory responses to intravenous histamine and phenyl diguanide in rabbits. J. Physiol. (London) 201: 271–291, 1969.
Karlsson, J.A., G. Sant’Ambrogio, and J. Widdicombe: Afferent neural pathways in cough and reflex bron-choconstriction. J. Appl. Physiol. 65: 1007–1023, 1988.
Lipski J., K. Ezure and R.B. Wong She: Identification of neurons receiving input from pulmonary rapidly adapting receptors in the cat. J. Physiol. (London) 443: 55–77, 1991.
Mills, J.E., H. Sellick and J.G. Widdicombe: Activity of lung irritant receptors in pulmonary microem-bolism, anaphylaxis and drug-induced bronchoconstrictions. J. Physiol. (London) 203: 337–357, 1969.
Nadel, J.A. and J.G. Widdicombe: Reflex effects of upper airway irritation on total lung resistance and blood pressure. J. Appl. Physiol. 17: 861–865, 1962.
Pack, A.I.: Sensory inputs to the medulla. Ann. Rev. Physiol. 43: 73–90, 1981.
Paintal, A.S.: Vagal sensory receptors and their reflex effects. Physiol. Rev. 53: 159–226, 1973.
Paintal, A.S.: The nature and effects of sensory inputs into the respiratory centers. Federation Proc. 36: 2428–2432, 1977.
Roberts, A.M., M.P. Kaufman, D.G. Baker, J.K. Brown, H.M. Coleridge, and J.C.G. Coleridge: Reflex tracheal contraction induced by stimulation of bronchial C-fibers in dogs. J. Appl. Physiol. 51: 485–493, 1981.
Sampson, S.R. and E.H. Vidruk: Chemical stimulation of rapidly adapting receptors in the airways. Adv. Exp. Med. Biol. 99: 281–290, 1978.
Sant’Ambrogio, G.: Afferent pathways for the cough reflex. Bull. Eur. Physiopathol. Respir. 23: 19s-23s, 1987.
Sant’Ambrogio, G.: Afferent nerves in reflex bronchoconstriction. Bull. Eur. Physiopathol. Respir. 23: 81s-88s, 1987.
Sellick, H., and J.G. Widdicombe: The activity of lung irritant receptors during pneumothorax, hyperpnoea and pulmonary vascular congestion. J. Physiol. (London) 203: 359–381, 1969.
Sellick, H. and J.G. Widdicombe: Stimulation of lung irritant receptors by cigarette smoke, carbon dust, and histamine aerosol. J. Appl. Physiol. 31: 15–19,1971.
Sheppard, D., N.W. Rizk, H.A. Boushey and R.A. Bethel: Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Am. Rev. Respir. Dis. 127: 691–694, 1983.
Tatar, M., S.E. Webber and J.G. Widdicombe: Lung C-fiber receptor activation and defensive reflexes in anaesthetized cats. J. Physiol. (London) 402: 411–420, 1988.
Tomori, Z., J.G. Widdicombe: Muscular, bronchomotor and cardiovascular reflexes elicited by mechanical stimulation of the respiratory tract. J. Physiol. (London) 200: 25–49, 1969.
Widdicombe, J.G.: Respiratory reflexes from the trachea and bronchi of the cat. J. Physiol. (London) 123: 55–70, 1954.
Widdicombe, J.G.: Neurophysiology of the cough reflex. Eur. Respir. J. 8: 1193–1202, 1995.
Yu, J., J.C.G. Coleridge and H.M. Coleridge: Influence of lung stiffness on rapidly adapting receptors in rabbits and cats. Respir. Physiol. 68: 161–176, 1987.
Yu, J., and S. Mink: Activation of pulmonary rapidly adapting receptors does not induce bronchoconstriction in dogs. J. Appl. Physiol. 80: 233–239, 1996.
Yu, J., H. Schultz, J. Goodman, J.C.G. Coleridge, H.M. Coleridge and B. Davis: Pulmonary rapidly adapting receptors reflexly increase airway secretion in dogs. J. Appl. Physiol. 67: 682–687, 1989.
Yu, J., J.F. Zhang, A.M. Roberts, L. Collins and E.C. Fletcher: Effects of activation of airway rapidly adapting receptors (RARs) on airway resistance in the rabbit. Am. J. Respir. Crit. Care Med. 153: A846, 1996.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Yu, J. (1998). Pulmonary Rapidly Adapting Receptors and Airway Constriction. In: Hughson, R.L., Cunningham, D.A., Duffin, J. (eds) Advances in Modeling and Control of Ventilation. Advances in Experimental Medicine and Biology, vol 450. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9077-1_26
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9077-1_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9079-5
Online ISBN: 978-1-4757-9077-1
eBook Packages: Springer Book Archive