Selective Depression of Peripheral Chemoreflex Loop by Sevoflurane in Lightly Anesthetized Cats
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 450)
In animal studies it has been shown that volatile anesthetics depress the ventilatory response to hypoxia and hypercapnia compared to the awake state.1,2 The findings that 0.5–1% halothane reduces activity in afferent nerve fibres of the carotid bodies,3 and that halothane, enflurane and isoflurane inhibit CO2-O2 interaction1,2, indicate that these inha-lational anesthetics may directly act on the peripheral chemoreceptors. This, however, was not confirmed by Berkenbosch and coworkers,4,5 who found that in cats lightly anesthetized with chloralose-urethane, overall anesthesia with halothane, or selective administration of this agent to the peripheral chemoreceptors reduced the gains of the peripheral and central chemoreflex loops to the same extent.
KeywordsCarotid Body Volatile Anesthetic Ventilatory Response Afferent Nerve Fibre Peripheral Chemoreceptor
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