Effect of Prior O2 Breathing on Hypoxic Hypercapnic Ventilatory Responses in Humans

  • A. Masuda
  • T. Kobayashi
  • Y. Ohyabu
  • T. Nishino
  • S. Masuyama
  • H. Kimura
  • T. Kuriyama
  • H. Tani
  • T. Komatsu
  • Y. Honda
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 450)


In the previous communication(11), we reported that prior O2 breathing lasted for 10 min effectively augmented the subsequent ventilatory level in isocapnic sustained hypoxia. In addition, we found that involvement of a humoral agent, excitatory amino acid glutamate, may be responsible for inducing this phenomenon.


Ventilatory Response Hyperoxic Exposure Plasma Glutamine Level Plasma Glutamate Isocapnic Hypoxia 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • A. Masuda
    • 1
  • T. Kobayashi
    • 2
  • Y. Ohyabu
    • 3
  • T. Nishino
    • 4
  • S. Masuyama
    • 5
  • H. Kimura
    • 5
  • T. Kuriyama
    • 5
  • H. Tani
    • 6
  • T. Komatsu
    • 7
  • Y. Honda
    • 8
  1. 1.Department of Physiology and Biochemistry, School of NursingChiba UniversityJapan
  2. 2.Health Science CenterTokyo University of Mercantile MarineJapan
  3. 3.Department of Physical EducationKogakuin UniversityJapan
  4. 4.Department of AnestheologyJapan
  5. 5.Department of Chest Medicine, School of MedicineChiba UniversityJapan
  6. 6.Department of Physical TherapyInternational University of Health and WelfareOhdawaraJapan
  7. 7.School of Allied Medical SciencesChibaJapan
  8. 8.Department of Physiology, School of MedicineChiba UniversityChiba 260Japan

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