Antibodies to Lactoferrin
Individuals with various forms of autoimmunity often develop autoantibodies to neutrophil components collectively known as ANCA (anti-neutrophil cytoplasmic antibodies). Two forms can be distinguished according to the pattern of localisation of these autoantibodies. In one form (c-ANCA) staining is predominantly cytoplasmic1, whereas in the other (p-ANCA) staining is perinuclear2. In the latter IgG antibodies predominate and one of the neutrophil antigens involved is lactoferrin3. Why lactoferrin should act as an autoantigen is not clear.
KeywordsCrescentic Glomerulonephritis Human Lactoferrin Bovine Lactoferrin Neutrophil Antigen Necrotizing Crescentic Glomerulonephritis
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