A Study of Lactoferrin and Antibodies Against Lactoferrin in Neurological Diseases

  • Silvana Penco
  • Barbara Villaggio
  • GianLuigi Mancardi
  • Michele Abbruzzese
  • Cecilia Garre
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 443)

Abstract

Lactoferrin (Lf) mediates some of the effects of inflammation and has a role in regulating various components of the immune system1. Marked elevation of Lf has been noted in the cerebrospinal fluid of patients with acute cerebrovascular lesions as an index of inflammation2. Furthermore, comparative immuno-histochemical analysis has revealed that Lf is present in pathological lesions in a variety of neurodegenerative disorders3. Previous studies have reported the presence of antibodies to Lf in the serum of patients with a wide variety of autoimmune disorders such as primary sclerosing cholangitis, ulcerative colitis, systemic lupus erytematosous. The clinical significance of these findings remains to be elucidated4.

Keywords

Multiple Sclerosis Ulcerative Colitis Multiple Sclerosis Patient Primary Sclerosing Cholangitis Significant Negative Relationship 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    B. Lonnerdal and S. lyer. Lactoferrin: molecular structure and biological function. Ann: Rev. Nutr 1995, 15: 93–110Google Scholar
  2. 2.
    A. Terent et al. Lactoferrin lysozyme and 13-microglobulin in cerebrospinal fluid. Stroke 1981, 12: 40–46PubMedCrossRefGoogle Scholar
  3. 3.
    B. Leveugle, G. Spik, D.P. Perl, C. Bouras, H.M. Fillit, P.R. Hof. The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis. Brain Res 1994, 650: 20–31PubMedCrossRefGoogle Scholar
  4. 4.
    P.F. Levay and M. Vijoen. Lactoferrin: a general review. Haematologica 1995, 80: 252–267PubMedGoogle Scholar
  5. 5.
    L. Steinman. Multiple Sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 1996, 85: 299–302PubMedCrossRefGoogle Scholar
  6. 6.
    J.E. Merrill and G.M. Jonakait. Interaction of the nervous and immune systems in development, normal brain homeostasis, and disease. The FASEB J. 1995, 9: 611–618Google Scholar
  7. 7.
    S. Penco, S. Pastorino, G. Bianchi-Scarra, C. Garre’. Lactoferrin down-modulates the activity of the Granulocyte Macrophage Colony Stimulating Factor promoter in Interleukin-1 [3-stimulated cells. J Biol Chem 1995, 270: 12263–12268PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Silvana Penco
    • 1
  • Barbara Villaggio
    • 2
  • GianLuigi Mancardi
    • 3
  • Michele Abbruzzese
    • 3
  • Cecilia Garre
    • 1
  1. 1.Institute of Biology and GeneticsUniversity of GenovaGenovaItaly
  2. 2.Department of Internal MedicineUniversity of GenovaGenovaItaly
  3. 3.Department of Neurological SciencesUniversity of GenovaGenovaItaly

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