A Study of Lactoferrin and Antibodies Against Lactoferrin in Neurological Diseases
Lactoferrin (Lf) mediates some of the effects of inflammation and has a role in regulating various components of the immune system1. Marked elevation of Lf has been noted in the cerebrospinal fluid of patients with acute cerebrovascular lesions as an index of inflammation2. Furthermore, comparative immuno-histochemical analysis has revealed that Lf is present in pathological lesions in a variety of neurodegenerative disorders3. Previous studies have reported the presence of antibodies to Lf in the serum of patients with a wide variety of autoimmune disorders such as primary sclerosing cholangitis, ulcerative colitis, systemic lupus erytematosous. The clinical significance of these findings remains to be elucidated4.
KeywordsMultiple Sclerosis Ulcerative Colitis Multiple Sclerosis Patient Primary Sclerosing Cholangitis Significant Negative Relationship
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