Abstract
Lactoferrin (Lf) mediates some of the effects of inflammation and has a role in regulating various components of the immune system1. Marked elevation of Lf has been noted in the cerebrospinal fluid of patients with acute cerebrovascular lesions as an index of inflammation2. Furthermore, comparative immuno-histochemical analysis has revealed that Lf is present in pathological lesions in a variety of neurodegenerative disorders3. Previous studies have reported the presence of antibodies to Lf in the serum of patients with a wide variety of autoimmune disorders such as primary sclerosing cholangitis, ulcerative colitis, systemic lupus erytematosous. The clinical significance of these findings remains to be elucidated4.
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References
B. Lonnerdal and S. lyer. Lactoferrin: molecular structure and biological function. Ann: Rev. Nutr 1995, 15: 93–110
A. Terent et al. Lactoferrin lysozyme and 13-microglobulin in cerebrospinal fluid. Stroke 1981, 12: 40–46
B. Leveugle, G. Spik, D.P. Perl, C. Bouras, H.M. Fillit, P.R. Hof. The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis. Brain Res 1994, 650: 20–31
P.F. Levay and M. Vijoen. Lactoferrin: a general review. Haematologica 1995, 80: 252–267
L. Steinman. Multiple Sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 1996, 85: 299–302
J.E. Merrill and G.M. Jonakait. Interaction of the nervous and immune systems in development, normal brain homeostasis, and disease. The FASEB J. 1995, 9: 611–618
S. Penco, S. Pastorino, G. Bianchi-Scarra, C. Garre’. Lactoferrin down-modulates the activity of the Granulocyte Macrophage Colony Stimulating Factor promoter in Interleukin-1 [3-stimulated cells. J Biol Chem 1995, 270: 12263–12268
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Penco, S., Villaggio, B., Mancardi, G., Abbruzzese, M., Garre, C. (1998). A Study of Lactoferrin and Antibodies Against Lactoferrin in Neurological Diseases. In: Spik, G., Legrand, D., Mazurier, J., Pierce, A., Perraudin, JP. (eds) Advances in Lactoferrin Research. Advances in Experimental Medicine and Biology, vol 443. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9068-9_37
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DOI: https://doi.org/10.1007/978-1-4757-9068-9_37
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