Antiviral Activity of Lactoferrin

  • Piera Valenti
  • Magda Marchetti
  • Fabiana Superti
  • Maria Grazia Amendolia
  • Patrizia Puddu
  • Sandra Gessani
  • Paola Borghi
  • Filippo Belardelli
  • Giovanni Antonini
  • Lucilla Seganti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 443)


In 1976, Matthews et al.19 reported the antiviral activity of milk proteins, underlining their possible clinical importance. Only recently, this effect has been ascribed mainly to lactoferrin (Lf). Lf was initially shown to exert a protective influence in mice infected with Friend leukemia virus15. Subsequently, a potent antiviral activity has been attributed to Lf, both in vitro towards cytomegalovirus (HCMV)9,7, herpes simplex virus (HSV)17, human immunodeficiency virus (HIV)7,29 and in vivo towards HSV-16 and HCMV25. Our groups provided evidence on the antiviral activity of Lf towards HSV-218, rotavirus28, and HIV22 infections (Table 1).


Human Immunodeficiency Virus Human Immunodeficiency Virus Type Antiviral Activity Herpes Simplex Virus Type Ferric Citrate 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Piera Valenti
    • 1
  • Magda Marchetti
    • 2
  • Fabiana Superti
    • 3
  • Maria Grazia Amendolia
    • 3
  • Patrizia Puddu
    • 4
  • Sandra Gessani
    • 5
  • Paola Borghi
    • 5
  • Filippo Belardelli
    • 5
  • Giovanni Antonini
    • 6
  • Lucilla Seganti
    • 2
  1. 1.Institute of MicrobiologyII University of NaplesItaly
  2. 2.Institute of MicrobiologyUniversity of Rome “La Sapienza”Italy
  3. 3.Department of UltrastructuresNational Institute of HealthRomeItaly
  4. 4.Laboratory of ImmunologyNational Institute of HealthRomeItaly
  5. 5.Laboratory of VirologyNational Institute of HealthRomeItaly
  6. 6.Department of Basic and Applied BiologyUniversity of l’AquilaItaly

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