Host Defensive Effects of Orally Administered Bovine Lactoferrin

  • Mamoru Tomita
  • Koji Yamauchi
  • Susumu Teraguchi
  • Hirotoshi Hayasawa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 443)


Lactoferrin, an iron-binding glycoprotein of the transferrin family, is present in milk, saliva, mucous secretions and many other body fluids1. Lactoferrin is a major component of the secondary granules in neutrophils and this protein is released from activated neutrophils in the inflammatory response2. Many biological functions have been attributed to this protein, including roles in bacteriostasis in milk and at mucosal surfaces, immunomodulation, regulation of cell proliferation and intestinal iron transport3. Since the majority of the proposed functions of lactoferrin are based on the results of in vitro experiments, it seems clear that more in vivo studies are required for better understanding of the biological role of this protein. Considering the high similarities among the physicochemical properties of lactoferrins from several species with respect to molecular weight, primary structures4,5, three-dimensional structures6,7, and isoelectric point8, it seems possible that administered lactoferrin isolated from bovine milk may exert physiological activities in other animals and humans. In this paper, we outline research results demonstrating host defensive effects of orally administered bovine lactoferrin observed in several in vivo studies performed by our research group and some of our collaborators.


Phagocytic Activity Bacterial Translocation Feline Immunodeficiency Virus Bovine Milk Blood Neutrophil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Mamoru Tomita
    • 1
  • Koji Yamauchi
    • 1
  • Susumu Teraguchi
    • 1
  • Hirotoshi Hayasawa
    • 1
  1. 1.Nutritional Science LaboratoryMorinaga Milk Industry Co., Ltd.Zama-City, Kanagawa 228Japan

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