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Structural Defects in Inherited and Giant Platelet Disorders

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Advances in Human Genetics

Part of the book series: Advances in Human Genetics ((AHUG,volume 19))

Abstract

These have been heady years for people in platelet research. Advances in biochemical techniques have made it possible to define the basic abnormalities of major inherited disorders of platelet function. Deficiencies in specific platelet surface membrane glycoproteins have been characterized, and are responsible for the functional failure of platelets from patients with the Bernard-Soulier syndrome (BSS) and Glanzman’s thrombasthenia, as well as individuals whose platelets do not adhere to collagen (George et al. 1985). Absence of defective function of cyclooxygenase and thromboxane synthetase enzymes required to form a thromboxane A2 have been found in familial hemorrhagic conditions (Gerrard, 1985). Impaired release or absence of secretory products or storage organelles have been shown to affect platelet function in vitro and in vivo (White, 1989). Continued improvements in technology will undoubtedly result in clarification of the molecular basis for all of the known platelet disorders and new ones yet to be discovered.

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  1. Departments of Laboratory Medicine/Pathology and Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, 55455, USA

    James G. White

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  1. University of Pennsylvania, Philadelphia, USA

    Harry Harris (Harnwell Professor of Human Genetics) (Harnwell Professor of Human Genetics)

  2. Mount Sinai School of Medicine of The City University of New York, USA

    Kurt Hirschhorn (Herbert H. Lehman Professor and Chairman of Pediatrics) (Herbert H. Lehman Professor and Chairman of Pediatrics)

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White, J.G. (1990). Structural Defects in Inherited and Giant Platelet Disorders. In: Harris, H., Hirschhorn, K. (eds) Advances in Human Genetics. Advances in Human Genetics, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9065-8_3

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