A Novel Closed Loop Cryosurgical Device

  • John Dobak
  • Xiaoyu Yu
  • Kambiz Ghaerzadeh
Part of the Advances in Cryogenic Engineering book series (ACRE, volume 43)


A novel cryosurgical device has been developed that dramatically improves the cost, convenience, safety, and effectiveness of cryosurgical devices. The device incorporates a mixed gas J-T stage. The fluid mixture is non flammable, non toxic, non corrosive, environmentally safe, and therefore suitable for medical applications. The system is compressor driven utilizing a novel oil free motor. Working temperatures of -115 to -125 °C at pressures of 300 to 350 psi are achieved. Approximately 20 watts of refrigeration are delivered at -120 °C.

The compressor console is portable having a 4 cu-ft volumetric footprint. The cryoprobe has a handle 3.5 cm O.D. and 18 cm length with a probe shaft having a 4 mm O.D. and a 3.5 cm freeze zone. In bench top studies using tissue simulating media (2% gelatin, 98% saline) ice balls of 3.5 – 4.0 cm diameter and 5 cm length with a mass of 48 grams are created. Studies using calf liver tissue in a body temperature water bath show ice balls of similar size and mass (3.5 cm diameter, 48 g). In live goat animal studies, surface temperatures of -115 °C were achieved, and ice balls of 3.8 cm in diameter were created in 10 minutes in the liver. Isotherms below -20 °C were developed at 12 mm radial distance from the probe.


Heat Exchanger Cool Capacity Freeze Zone Ofthe Probe Counter Flow Heat Exchanger 
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  1. 1.
    I. S. Cooper, in: “Cryogenics in surgery” H. von Leden and W. G. Cahan eds., Medical Examination Publishing Company, Inc., Flushing, (1971), pp. 1–38 and p. 155.Google Scholar
  2. 2.
    R. Orpwood, Phys Med Biol 26: 555 (1981).CrossRefGoogle Scholar
  3. 3.
    A. Gage and D. Torre, “Encyclopedia of Medical Devices and Instrumentation,” Wiley, New York (1988).Google Scholar
  4. 4.
    H. Lenz and J. Eichler, Cryobiology 13: 37 (1976).CrossRefGoogle Scholar
  5. 5.
    T. E. Cooper and G. J. Petrovic, Journal of Heat Transfer 96: 415 (1974).CrossRefGoogle Scholar
  6. 6.
    “Dangerous Properties of Industrial Materials” Van Nostrand Reinhold, New York (1992).Google Scholar
  7. 7.
    K. Tatsutani, B. Rubinsky, G. Onik, and R. Dahiya, Urology 48: 441 (1996).CrossRefGoogle Scholar
  8. 8.
    W. Gill, J. Fraser, and D. Carter, Nature 219: 410 (1968).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • John Dobak
    • 1
  • Xiaoyu Yu
    • 1
  • Kambiz Ghaerzadeh
    • 1
  1. 1.CryoGen, Inc.San DiegoUSA

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