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Surface Layers from Bacillus alvei as a Carrier for a Streptococcus pneumoniae Conjugate Vaccine

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Advances in Bacterial Paracrystalline Surface Layers

Part of the book series: NATO ASI Series ((NSSA,volume 252))

Abstract

Approaches to the use of crystalline bacterial cell surface layers (S-layers) as carrier/adjuvants for conjugate vaccines have been reported recently (Sleytr et al., 1987; Sleytr et al., 1988; Malcolm, et al., 1993; Messner and Sleytr, 1992; Messner et al., 1992; Smith et al., in press). In this chapter, we report on some of the results we have obtained using an S-layer derived from Bacillus alvei CCM 2051 (Altman et al., 1991) as a carrier for a prototype conjugate vaccine against Streptococcus pneumoniae, serotype 8.

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Author notes

  1. Andrew J. Malcolm, Michael W. Best, Roderick J. Szarka & Zina Mosleh

    Present address: Alberta Research Council, P. O. Box 8330, Edmonton, Alberta, Canada, T6H 5X2

Authors and Affiliations

  1. Chembiomed Ltd., Edmonton, Alberta, Canada

    Andrew J. Malcolm, Michael W. Best, Roderick J. Szarka, Zina Mosleh & Frank M. Unger

  2. Center for Ultrastructure Research and Ludwig Boltzman Institute for Molecular Nanotechnology, University of Agriculture, Vienna, Austria

    Paul Messner & Uwe B. Sleytr

Authors
  1. Andrew J. Malcolm
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  2. Michael W. Best
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  3. Roderick J. Szarka
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  4. Zina Mosleh
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  5. Frank M. Unger
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  6. Paul Messner
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  7. Uwe B. Sleytr
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Editors and Affiliations

  1. University of Guelph, Guelph, Ontario, Canada

    Terry J. Beveridge

  2. University of Western Ontario, London, Ontario, Canada

    Susan F. Koval

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Malcolm, A.J. et al. (1993). Surface Layers from Bacillus alvei as a Carrier for a Streptococcus pneumoniae Conjugate Vaccine. In: Beveridge, T.J., Koval, S.F. (eds) Advances in Bacterial Paracrystalline Surface Layers. NATO ASI Series, vol 252. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9032-0_21

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  • DOI: https://doi.org/10.1007/978-1-4757-9032-0_21

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