Variability in Human Cardiovascular Pharmacodynamics

  • Darrell R. Abernethy


An often-stated comment from researchers in aging is that the consistent hallmark of increasing age is increasing variability for measured parameters within a population. The various components of cardiovascular function in the aging human generally fit this maxim. Here an attempt will be made to characterize aspects of pharmacodynamic variability in aging and explore some of the various components of physiological variability that contribute to measurable pharmacodynamic endpoints. The approach will stress that useful cardiovascular pharmacodynamic endpoints (e. g., blood pressure, heart rate, cardiac output, etc.) are complex parameters derived from interacting components. Blood pressure, for example, characterized in terms of hemodynamics is a function of cardiac output, vascular compliance, and vascular resistance. Cardiac output is comprised of heart rate and contractility, while contractility may be usefully separated into systolic and diastolic components.


Atrial Natriuretic Peptide Left Ventricular Filling Diastolic Filling Atrial Natriuretic Factor Vascular Compliance 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Darrell R. Abernethy
    • 1
  1. 1.Program in Clinical PharmacologyBrown UniversityUSA

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