Fertilization in Man

  • Don P. Wolf
  • Susan E. Lanzendorf


Clinical IVF-ET was initiated with the birth of baby Louise Brown in 1978 following several years of pioneering effort by Patrick Steptoe and Robert Edwards. In the ensuing 12 years, human IVFET has evolved into standard medical practice for the treatment of many types of infertility, and the service is now offered by some 700 clinics in 48 countries. The application, confined originally to the hopelessly infertile patient with irreparably damaged or absent fallopian tubes, has expanded to include idiopathic, male, endometriosis, cervical, and immunologic etiologies. About 15% of egg retrieval cycles end in pregnancy and live birth resulting from the transfer of, on average, three embryos. Over 15,000 babies have been born by IVF-ET, which means that the experience base in man exceeds that in all other mammalian species with the possible exception of the mouse. A summary of the IVF experience in the United States for 1987 has appeared (Medical Research International et al., 1989). Several peer-reviewed journals now devote major attention to the clinical and applied aspects of IVF—Fertility and Sterility, Human Reproduction, and Journal of In Vitro Fertilization and Embryo Transfer.


Embryo Transfer Assisted Reproductive Technology Seminal Plasma Zona Pellucida Human Sperm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Don P. Wolf
    • 1
    • 2
  • Susan E. Lanzendorf
    • 1
  1. 1.Division of Reproductive Biology and BehaviorOregon Regional Primate Research CenterBeavertonUSA
  2. 2.Department of Obstetrics/GynecologyOregon Health Sciences UniversityPortlandUSA

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