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Fertilization in Man

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A Comparative Overview of Mammalian Fertilization

Abstract

Clinical IVF-ET was initiated with the birth of baby Louise Brown in 1978 following several years of pioneering effort by Patrick Steptoe and Robert Edwards. In the ensuing 12 years, human IVFET has evolved into standard medical practice for the treatment of many types of infertility, and the service is now offered by some 700 clinics in 48 countries. The application, confined originally to the hopelessly infertile patient with irreparably damaged or absent fallopian tubes, has expanded to include idiopathic, male, endometriosis, cervical, and immunologic etiologies. About 15% of egg retrieval cycles end in pregnancy and live birth resulting from the transfer of, on average, three embryos. Over 15,000 babies have been born by IVF-ET, which means that the experience base in man exceeds that in all other mammalian species with the possible exception of the mouse. A summary of the IVF experience in the United States for 1987 has appeared (Medical Research International et al., 1989). Several peer-reviewed journals now devote major attention to the clinical and applied aspects of IVF—Fertility and Sterility, Human Reproduction, and Journal of In Vitro Fertilization and Embryo Transfer.

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Author information

Author notes

  1. Susan E. Lanzendorf

    Present address: The Jones Institute for Reproductive Medicine, Department of Obstetrics/Gynecology, Eastern Virginia Medical School, Norfolk, Virginia, 23510, USA

Authors and Affiliations

  1. Division of Reproductive Biology and Behavior, Oregon Regional Primate Research Center, Beaverton, Oregon, 97006, USA

    Don P. Wolf & Susan E. Lanzendorf

  2. Department of Obstetrics/Gynecology, Oregon Health Sciences University, Portland, Oregon, 97201, USA

    Don P. Wolf

Authors
  1. Don P. Wolf
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  2. Susan E. Lanzendorf
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Editor information

Editors and Affiliations

  1. Department of Cell Biology, Baylor College of Medicine, 77030, Houston, Texas, USA

    Bonnie S. Dunbar

  2. Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, North Carolina, USA

    Michael G. O’Rand

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© 1991 Springer Science+Business Media New York

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Wolf, D.P., Lanzendorf, S.E. (1991). Fertilization in Man. In: Dunbar, B.S., O’Rand, M.G. (eds) A Comparative Overview of Mammalian Fertilization. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-8982-9_20

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  • DOI: https://doi.org/10.1007/978-1-4757-8982-9_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-8984-3

  • Online ISBN: 978-1-4757-8982-9

  • eBook Packages: Springer Book Archive

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