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Visual Development pp 165–173Cite as

Long-Term Potentiation as a Model

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Part of the book series: Perspectives in Vision Research ((PIVR))

Abstract

Long-term potentiation (LTP) is a strengthening of synaptic transmission that was first discovered in the hippocampus (Bliss and Lomo, 1973). If one stimulates the afférents to the hippocampus at a high rate (100 Hz for 3 sec), the excitatory postsynaptic potentials in the hippocampal pyramidal cells are subsequently found to be larger than normal, and to rise more quickly. The effect lasts for several hours, and can last for as long as the preparation does.

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References

  • Alford, S., Frenguelli, B. G., Schofield, J. G., and Collingridge, G. L., 1993, Characterization of Ca2+ signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors, J. Physiol (London) 469:693–716.

    CAS  Google Scholar 

  • Artola, A., and Singer, W., 1987, Long-term potentiation and NMDA receptors in rat visual cortex, Nature 330:649–652.

    Article  PubMed  CAS  Google Scholar 

  • Bannerman, D. M., Chapman, P. F., Kelly, P. A. T., Butcher, S. P., and Morris, R. G. M., 1994a, Inhibition of nitric oxide synthase does not impair spatial learning, J. Neurosci. 14:7404–7414.

    PubMed  CAS  Google Scholar 

  • Bannerman, D. M., Chapman, P. F., Kelly, P. A. T., Butcher, S. P., and Morris, R. G. M., 1994b, Inhibition of nitric oxide synthase does not prevent the induction of long-term potentiation in vivo, J. Neurosci. 14:7415–7425.

    PubMed  CAS  Google Scholar 

  • Barbour, B., Szatkowski, M., Ingledew, N., and Attwell, D., 1989, Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells, Nature 342:918–920.

    Article  PubMed  CAS  Google Scholar 

  • Bashir, Z. I., Bortolotto, Z. A., Davies, C. H., Beretta, N., Irving, A. J., Seal, A. J., Henley, J. M., Jane, D. E., Watkins, J. C, and Collingridge, G. L., 1993, Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors, Nature 363:347–350.

    Article  PubMed  CAS  Google Scholar 

  • Bliss, T. V. P., and Collingridge, G. L., 1993, A synaptic model of memory: Long-term potentiation in the hippocampus, Nature 361:31–39.

    Article  PubMed  CAS  Google Scholar 

  • Bliss, T. V. P., and Lomo, T., 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulation of the perforant path, J. Physiol. (London) 232:331–356.

    CAS  Google Scholar 

  • Bliss, T. V. P., Errington, M. L., Lynch, M. A., and Williams, J. H., 1990, Presynaptic mechanisms in hippocampal long-term potentiation, Cold Spring Harbor Symp. Quant. Biol. 55:119–129.

    Article  PubMed  CAS  Google Scholar 

  • Bohme, G. A., Bon, C, Stutzmann, J. M., Doble, A., and Blanchard, J. C., 1991, Possible involvement of nitric oxide in long-term potentiation, Eur. J. Pharmacol. 199:379–381.

    Article  PubMed  CAS  Google Scholar 

  • Chetkovitch, D. M., Gray, R., Johnston, D., and Sweatt, J. D., 1991, N-methyl-D-aspartate receptor activation increases cAMP levels and voltage-gated Ca2+ channel activity in area CA1 of hippocampus, Proc. Natl. Acad. Sci. USA 88:6467–6471.

    Article  Google Scholar 

  • Collingridge, G. L., Kehl, S. J., and McLennan, H., 1983, Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus, J. Physiol. (London) 334:33–46.

    CAS  Google Scholar 

  • Collingridge, G. L., Herron, C. E., and Lester, R. A. J., 1988, Frequency-dependent N-methyl-D-aspartate receptor-mediated synaptic transmission in rat hippocampus, J. Physiol. (London) 399:301–312.

    CAS  Google Scholar 

  • Dingledine, R., 1983, N-methyl aspartate activates voltage-dependent calcium conductance in rat hippocampal pyramidal cells, J. Physiol. (London) 343:385–405.

    CAS  Google Scholar 

  • Dudek, S. M., and Bear, M. F., 1992, Homosynaptic long-term depression in area CAl of hippocampus and effects of N-methyl-D-aspartate receptor blockade, Proc. Natl. Acad. Sci. USA 89:4363–4367.

    Article  PubMed  CAS  Google Scholar 

  • Dumuis, A., Sebben, M., Haynes, L., Pin, J. P., and Bockaert, J., 1988, NMDA receptors activate the arachidonic acid cascade system in striatal neurons, Nature 336:68–70.

    Article  PubMed  CAS  Google Scholar 

  • Fox, K., and Daw, N. W., 1992, A model for the action of NMDA conductances in the visual cortex, Neural Computation 4:59–83.

    Article  Google Scholar 

  • Fox, K., Sato, H., and Daw, N. W., 1990, The effect of varying stimulus intensity on NMDA-receptor activity in cat visual cortex, J. Neurophysiol. 64:1413–1428.

    PubMed  CAS  Google Scholar 

  • Frey, U., Huang, Y. Y., and Kandel, E. R., 1993, Effects of cAMP simulate a late stage of LTP in hippocampal CAl neurons, Science 260:1661–1664.

    Article  PubMed  CAS  Google Scholar 

  • Gribkoff, V. K., and Lum-Ragan, J. T., 1992, Evidence for nitric oxide synthase inhibitor-sensitive and insensitive hippocampal synaptic potentiation, J. Neurophysiol. 68:639–642.

    PubMed  CAS  Google Scholar 

  • Haley, J. E., Wilcox, G. L., and Chapman, P. F., 1992, The role of nitric oxide in hippocampal long-term potentiation, Neuron 8:211–216.

    Article  PubMed  CAS  Google Scholar 

  • Haley, J. E., Malen, P. L., and Chapman, P. F., 1993, Nitric oxide synthase inhibitors block LTP induced by weak but not strong tetanic stimulation, Soc. Neurosci. Abstr. 19:906.

    Google Scholar 

  • Halpain, S., and Greengard, P., 1990, Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2, Neuron 5:237–246.

    Article  PubMed  CAS  Google Scholar 

  • Kato, N., 1993, Dependence of long-term depression on postsynaptic metabotropic glutamate receptors in visual cortex, Proc. Natl. Acad. Sci. USA 90:3650–3654.

    Article  PubMed  CAS  Google Scholar 

  • Kauer, J. A., Malenka, R. C, and Nicoll, R. A., 1988, A persistent postsynaptic modification mediates long-term potentiation in the hippocampus, Neuron 1:911–917.

    Article  PubMed  CAS  Google Scholar 

  • Klann, E., Chen, S. J., and Sweatt, J. D., 1991, Persistent protein kinase activation in the maintenance phase of long-term potentiation, J. Biol. Chem. 266:24253–24256.

    PubMed  CAS  Google Scholar 

  • Komatsu, Y., and Iwakiri, M., 1992, Low-threshold Ca2+ channels mediate induction of long-term potentiation in kitten visual cortex, J. Neurophysiol. 67:401–410.

    PubMed  CAS  Google Scholar 

  • Komatsu, Y., Fujii, K., Maeda, J., Sakaguchi, H., and Toyama, K., 1988, Long-term potentiation of synaptic transmission in kitten visual cortex, J. Neurophysiol. 59:124–141.

    PubMed  CAS  Google Scholar 

  • Krug, M., Lossner, B., and Ott, T., 1984, Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats, Brain Res. Bull. 13:39–42.

    Article  PubMed  CAS  Google Scholar 

  • Lisman, J., 1989, A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory, Proc. Natl. Acad. Sci. USA 86:9574–9578.

    Article  PubMed  CAS  Google Scholar 

  • Lisman, J. E., and Harris, K. M., 1993, Quantal analysis and synaptic anatomy—Integrating two views of hippocampal plasticity, Trends Neurosci. 16:141–147.

    Article  PubMed  CAS  Google Scholar 

  • Lovinger, D. M., and Routtenberg, A., 1988, Synapse-specific protein kinase C activation enhances maintenance of long-term potentiation in rat hippocampus, J. Physiol. (London) 400:321–333.

    CAS  Google Scholar 

  • Lynch, G., Larson, J., Kelso, S., Barrioneuvo, G., and Schottler, F., 1983, Intracellular injections of EGTA block induction of hippocampal long-term potentiation, Nature 305:719–721.

    Article  PubMed  CAS  Google Scholar 

  • Lynch, M. A., Errington, M. L., and Bliss, T. V. P., 1989, Nordihydroguaiaretic acid blocks the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate: An in vivo study in the dentate gyrus of the rat, Neuroscience 30:693–701.

    Article  PubMed  CAS  Google Scholar 

  • Malenka, R. C., Kauer, J. A., Zucker, R. S., and Nicoll, R. A., 1988, Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission, Science 242:81–84.

    Article  PubMed  CAS  Google Scholar 

  • Malenka, R. C., Kauer, J. A., Perkel, D. J., Mauk, M. D., Kelly, P. T., Nicoll, R. A., and Waxham, M. N., 1989a, An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation, Nature 340:554–557.

    Article  PubMed  CAS  Google Scholar 

  • Malenka, R. C., Kauer, J. A., Perkel, D. J., and Nicoll, R. A., 1989b, The impact of postsynaptic calcium on synaptic transmission—Its role in long-term potentiation, Trends Neurosci. 12: 444–450.

    Article  PubMed  CAS  Google Scholar 

  • Malinow, R., Schulman, H., and Tsien, R. W., 1989, Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP, Science 245:862–866.

    Article  PubMed  CAS  Google Scholar 

  • Miyakawa, H., Ross, W. N., Jaffe, D., Callaway, J. C, Lasser-Ross, N., Lisman, J. E., and Johnston, D., 1992, Synaptically activated increases in Ca2+ concentration in hippocampal CAl pyramidal cells are primarily due to voltage-gated Ca2+ channels, Neuron 9:1163–1173.

    Article  PubMed  CAS  Google Scholar 

  • Mulkey, R. M., and Malenka, R. C, 1992, Mechanisms underlying induction of homosynaptic long-term depression in area CAl of the hippocampus, Neuron 9:967–975.

    Article  PubMed  CAS  Google Scholar 

  • Mulkey, R. M., Herron, C. E., and Malenka, R. C, 1993, An essential role for protein phosphatases in hippocampal long-term depression, Science 261:1051–1055.

    Article  PubMed  CAS  Google Scholar 

  • Mulkey, R. M., Endo, S., Shenolikar, S., and Malenka, R. C., 1994, Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression, Nature 369: 486–488.

    Article  PubMed  CAS  Google Scholar 

  • Muller, D., Joly, M., and Lynch, G., 1988, Contributions of quisqualate and NMDA receptors to the induction and expression of LTP, Science 242:1694–1697.

    Article  PubMed  CAS  Google Scholar 

  • Musgrave, M. A., Ballyk, B. A., and Goh, J. W., 1993, Coactivation of metabotropic and NMDA receptors is required for LTP induction, Neuroreport 4:171–174.

    Article  PubMed  CAS  Google Scholar 

  • Nakanishi, S., 1992, Molecular diversity of glutamate receptors and implications for brain function, Science 258:597–603.

    Article  PubMed  CAS  Google Scholar 

  • Obenaus, A., Mody, I., and Baimbridge, K. G., 1989, Dantrolene-Na (Dantrium) blocks induction of long-term potentiation in hippocampal slices, Neurosci. Lett. 98:172–178.

    Article  PubMed  CAS  Google Scholar 

  • O’Dell, T. J., Hawkins, R. D., Kandel, E. R., and Arancio, O., 1991a, Tests of the roles of two diffusible substances in long-term potentiation: Evidence for nitric oxide as a possible early retrograde messenger, Proc. Natl. Acad. Sci. USA 88:11285–11289.

    Article  PubMed  Google Scholar 

  • O’Dell, T. J., Kandel, E. R., and Grant, S. G. N., 1991b, Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors, Nature 353:558–560.

    Article  PubMed  Google Scholar 

  • Otani, S., Marshall, C. J., Tate, W. P., Goddard, G. V., and Abraham, W. C., 1989, Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization, Neuroscience 28:519–526.

    Article  PubMed  CAS  Google Scholar 

  • Schuman, E. M., and Madison, D. V., 1991, A requirement for the intracellular messenger nitric oxide in long-term potentiation, Science 254:1503–1506.

    Article  PubMed  CAS  Google Scholar 

  • Silva, A. J., Stevens, C. F., Tonegawa, S., and Wang, Y., 1992, Deficient hippocampal long-term potentiation in α-calcium-calmodulin kinase II mutant mice, Science 257:201–206.

    Article  PubMed  CAS  Google Scholar 

  • Stanton, P. K., and Sarvey, J. M., 1984, Blockade of long-term potentiation in rat hippocampal CAl region by inhibitors of protein synthesis, J. Neurosci. 4:3080–3088.

    PubMed  CAS  Google Scholar 

  • Tsumoto, T., and Suda, K., 1979, Cross-depression: An electrophysiological manifestation of binocular competition in the developing visual cortex, Brain Res. 168:190–194.

    Article  PubMed  CAS  Google Scholar 

  • Williams, J. H., Errington, M. L., Lynch, M. A., and Bliss, T. V. P., 1989, Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus, Nature 341:739–742.

    Article  PubMed  CAS  Google Scholar 

  • Williams, J. H., Li, Y. G., Nayak, A., Errington, M. L., Murphy, K. P. S. J., and Bliss, T. V. P., 1993, The suppression of long-term potentiation in rat hippocampus by inhibitors of nitric oxide synthase is temperature and age dependent, Neuron 11:877–884.

    Article  PubMed  CAS  Google Scholar 

  • Zalutsky, R. A., and Nicoll, R. A., 1990, Comparison of two forms of long-term potentiation in single hippocampal neurons, Science 248:1619–1624.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Yale University Medical School, New Haven, Connecticut, UK

    Nigel W. Daw

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  1. Nigel W. Daw
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Daw, N.W. (1995). Long-Term Potentiation as a Model. In: Visual Development. Perspectives in Vision Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6940-1_11

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  • DOI: https://doi.org/10.1007/978-1-4757-6940-1_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6942-5

  • Online ISBN: 978-1-4757-6940-1

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