Long-Term Potentiation as a Model

  • Nigel W. Daw
Part of the Perspectives in Vision Research book series (PIVR)


Long-term potentiation (LTP) is a strengthening of synaptic transmission that was first discovered in the hippocampus (Bliss and Lomo, 1973). If one stimulates the afférents to the hippocampus at a high rate (100 Hz for 3 sec), the excitatory postsynaptic potentials in the hippocampal pyramidal cells are subsequently found to be larger than normal, and to rise more quickly. The effect lasts for several hours, and can last for as long as the preparation does.


Nitric Oxide Arachidonic Acid NMDA Receptor Visual Cortex Synaptic Transmission 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Nigel W. Daw
    • 1
  1. 1.Yale University Medical SchoolNew Haven, ConnecticutUK

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