α-Ketoglutarate Induced Transamination During Ischemic Exercise

  • C. Cerri
  • F. Fici
  • G. Scarlato
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 153)

Abstract

Administration of α-ketoglutarate (KGT) has been reported to reduce lactacidemia both in pathological conditions (Scarlato et al. 1981) and after exercise in normal subjects (Cerretelli et al. 1981). KGT could reduce lactacidemia by increasing the catabolism of pyruvate via either the Krebs cycle or by transamination. To discriminate between those two possibilities we investigated the effect of IV administration of KGT in subjects performing a standard ischemic work. As reported by Munsat (1970) ligation of the arm while performing a squeezing exercise with the hand blocks the utilization of pyruvate by the Krebs cycle. If KGT reduces lactacidemia favoring pyruvate utilization by the Krebs cycle, then administration of KGT should not change the blood level of lactate after exercise. Our results suggest that this is not the case.

Keywords

Pyruvic Acid Krebs Cycle Urea Cycle Ammonia Production Ischemic Exercise 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • C. Cerri
    • 1
  • F. Fici
    • 2
  • G. Scarlato
    • 1
  1. 1.Medical School Neurology DepartmentUniversity of MilanoMilanoItaly
  2. 2.Istituto Lusofarmaco d’ItaliaMilanoItaly

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