Effect of Guanidino Compounds on Hen Egg Development

  • Sonoko Seki
  • Noriyuki Yuyama
  • Midori Hiramatsu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 153)


It has been reported that levels of guanidinosuccinic acid,1 methylguanidine2, β-guanidinopropionic acid3 and taurocyamine in serum of uremic patients are significantly elevated compared to normal control subjects. Also, brain levels of taurocyamine and methylguanidine were found to be increaed in experimental uremia produced by bilateral urethral ligation4. Because of these results, methylguanidine, β-guanidinopropionic acid and guanidinosuccinic acid are becoming of interest as potential “uremic toxins”.


Butyric Acid Guanidine Hydrochloride Uremic Patient Glutaric Acid Uremic Toxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    P. P. Kamoun, J. M. Pleau and N. K. Man, Semiautomated method for measurement of guanidinosuccinic acid in serum, Clin. Chem., 18: 355 (1972).Google Scholar
  2. 2.
    L. R. I. Baker and R. D. Marshall, A Reinvestigation of methylguanidine concentrations in sera from uraemic subjects, Clin. Sci., 41: 563 (1 971).Google Scholar
  3. 3.
    I. M. Stein, G. Perez, R. Johnson and N. B. Cummings, Serum levels and urinary excretion of methylguanidine in chronic renal failure, J. Lab. Clin. Med., 77: 1020 (1971).PubMedGoogle Scholar
  4. M. Matsumoto, H. and A. Mori, Guanidino compounds in the sera of uremic patients and in the sera and brain of experimental uremic rabbits, Biochem. Med. 16: 1 (1976).Google Scholar
  5. 5.
    A. Mori, in press.Google Scholar
  6. 6.
    S. Seki, K. Ohe, T. Hirata, et al., Inhibitory effect of methionine sulfoximine on chick development, Kanagawa Shigaku 1: 16 (1967).Google Scholar
  7. 7.
    A. Mori, Y. Watanabe, S. Shindo and M. Hiramatsu, a-Guanidinoglutaric acid and epilepsy, Symposium on Urea Cycle Diseases Okayama, Japan (1981).Google Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Sonoko Seki
    • 1
  • Noriyuki Yuyama
    • 1
  • Midori Hiramatsu
    • 2
  1. 1.Department of PhysiologyKanagawa Dental CollegeYokosukaJapan
  2. 2.Department of Neurochemistry, Institute for NeurobiologyOkayama University Medical SchoolOkayamaJapan

Personalised recommendations