Guanidinosuccinic Acid and the Alternate Urea Cycle

  • B. D. Cohen
  • H. Patel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 153)


Disturbance in nitrogen balance is the hallmark of renal insufficiency. Unlike sodium, phosphate and the myriad other minerals which the kidney regulates and balances, nitrogen cannot be reutilized by animal organisms and is restored to the environment via the urine without mechanisms for reabsorption (except for the small quantity of amino acids which are filtered and can be reutilized). Reduced filtration leads to azotemia and sets in motion a variety of hormonally regulated adaptions.


Nitrogen Balance Urea Cycle Urea Production Bilateral Nephrectomy Guanidi Noacetate 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • B. D. Cohen
    • 1
  • H. Patel
    • 1
  1. 1.Bronx-Lebanon HospitalBronxUSA

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