Abstract
Disturbance in nitrogen balance is the hallmark of renal insufficiency. Unlike sodium, phosphate and the myriad other minerals which the kidney regulates and balances, nitrogen cannot be reutilized by animal organisms and is restored to the environment via the urine without mechanisms for reabsorption (except for the small quantity of amino acids which are filtered and can be reutilized). Reduced filtration leads to azotemia and sets in motion a variety of hormonally regulated adaptions.
“What seems to account for the general derangement and suffering (in uremia) is the fact that urea ... or the elements of which it is formed are abundant in the blood”. Richard Bright, 1833.
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© 1982 Springer Science+Business Media New York
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Cohen, B.D., Patel, H. (1982). Guanidinosuccinic Acid and the Alternate Urea Cycle. In: Lowenthal, A., Mori, A., Marescau, B. (eds) Urea Cycle Diseases. Advances in Experimental Medicine and Biology, vol 153. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6903-6_53
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DOI: https://doi.org/10.1007/978-1-4757-6903-6_53
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