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α-Guanidinoglutaric Acid and Epilepsy

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Urea Cycle Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 153))

Abstract

The application of metallic cobalt to the cerebral cortex results in an experimental model of chronic focal epilepsy1,2 Many biochemical studies on this focus tissue have been performed to explore seizure mechanism3–6, though the induction phenomenon itself is not well understood.

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References

  1. L. M. Kopeloff, Experimental epilepsy in the mouse, Proc. Soc. Exp. Med. 104: 500 (1960).

    CAS  Google Scholar 

  2. R. S. Dow, The production of cobalt experimental epilepsy in the rat, Electroencephalogr. Clin. Neurophysiol. 14: 399 (1962).

    Article  PubMed  CAS  Google Scholar 

  3. I. Koyama, Amino acids in the cobalt-induced epileptogenic and nonepileptogenic cat’s cortex, Can. J. Physiol. Pharmacol. 50: 740 (1972).

    Article  CAS  Google Scholar 

  4. N. M. Van Gelder, Glutamate dehydrogenase, glutamic acid decarboxylase, and GABA aminotransferase in epileptic mouse cortex, Can. J. Physiol. Pharmacol, 52: 952 (1974).

    Article  PubMed  Google Scholar 

  5. P. R. Dodd, H. F. Bradford, A. S. Abdnlghani, D. W. G. Cox and Continho-Netto, Release of amino acids from chronic epileptic and subepileptic foci in vivo, Brain Res. 193: 505 (1980).

    Google Scholar 

  6. S. M. Ross and C.R. Craig, Studies on y-aminobutyric acid transport in cobalt experimental epilepsy in the rat, J. Neurochem. 36: 1006 (1981).

    Article  PubMed  CAS  Google Scholar 

  7. A. Mori, M. Akagi, Y. Katayama and Y. Watanabe, Œ-Guanidinoglutaric acid in cobalt induced epileptogenic cerebral cortex of cats, J. Neurochem. 35: 603 (1980).

    Article  PubMed  CAS  Google Scholar 

  8. A. Mori, T. Ichimura and H, Matsumoto,Gas chromatography-mass spectrometry of guanidino compounds in brain, Anal. Biochem. 89: 393 (1978).

    Article  PubMed  CAS  Google Scholar 

  9. E. L. Peters and D. B. Tower, Glutamic acid and glutamine metabolism in cerebral cortex after seizures induced by methionine sulfoximine, J. Neurochem. 5: 80 (1959).

    Article  PubMed  CAS  Google Scholar 

  10. S. Berl, D. P. Purpura and H. Waelsch, Amino acid metabolism in epileptogenic and nonepileptogenic lesions of the neo-cortex (cat), J. Neurochem. 4: 311 (1959).

    Article  PubMed  CAS  Google Scholar 

  11. N. Mison-Crighel, N. Luca and E. Crighel, The effect of an epileptogenic focus, induced by topical application of mescaline on glutamic acid, glutamine and GABA in the neocortex of the cat, J. Neurochem. 11: 333 (1965).

    Article  Google Scholar 

  12. N. M. Van Gelder, A. L. Sherwin and T. Rasmussen, Amino acid content of epileptogenic human brain: Focus versus surrounding regions, Brain Res. 40: 385 (1972).

    Article  PubMed  Google Scholar 

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© 1982 Springer Science+Business Media New York

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Mori, A., Watanabe, Y., Shindo, S., Akagi, M., Hiramatsu, M. (1982). α-Guanidinoglutaric Acid and Epilepsy. In: Lowenthal, A., Mori, A., Marescau, B. (eds) Urea Cycle Diseases. Advances in Experimental Medicine and Biology, vol 153. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6903-6_51

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  • DOI: https://doi.org/10.1007/978-1-4757-6903-6_51

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6905-0

  • Online ISBN: 978-1-4757-6903-6

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