Immobilization of Multienzymes of Urea Cycle into Fibrin Membrane: An Approach to an Artificial Liver
The final obligatory step for the metabolism of nitrogeneous compounds in human body is the conversion of ammonia to urea through carbamyl phosphate and urea cycle with the aid of ATP. Accumulation of ammonia in human blood is observed for patients with liver failure and hepatic coma and gives rise to a serious damage to brain. The metabolic pathway for the urea synthesis from ammonia is shown below, which is mainly conducted in liver.
KeywordsUrea Cycle Hepatic Coma Urea Synthesis Immobilize System Inorganic Pyrophosphatase
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