Evolutionary Relationships between Arginine and Creatine in Muscle

  • F. J. R. Hird
  • Siva Prasad Davuluri
  • R. M. McLean
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 153)


In addition to being a constituent of proteins, arginine during evolution, has come to have important additional functions as a free amino acid. Thus, there have been three extensions to the metabolic pathway of its synthesis — phosphorylation to form phosphoarginine, hydrolysis to form urea, and transfer of its amidino group to certain amines to form a variety of guanidino compounds used as phosphagens in muscle. The present paper briefly refers to the special significance of arginine in the way it has permitted important evolutionary advances. It also raises the question of possible secondary effects of an arginine deficiency to the musculature and nervous system in the very young animal.


Creatine Kinase Arginine Kinase Total Creatine Rock Lobster Creatine Synthesis 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • F. J. R. Hird
    • 1
  • Siva Prasad Davuluri
    • 1
  • R. M. McLean
    • 1
  1. 1.Russell Grimwade School of BiochemistryUniversity of MelbourneParkvilleAustralia

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