Isolation of Argininosuccinase from Bovine Brain : Catalytic, Physical and Chemical Properties Compared to Liver and Kidney Enzymes

  • Kimiko Murakami-Murofushi
  • Sarah Ratner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 153)


Argininosuccinase together with argininosuccinate synthetase occurs in the brain of all ureotelic species as well as in other tissuesl. Considering the levels of these enzymes in brain and the amount of citrulline supplied via the circulation, they may play a role in the formation of arginine from citrulline in normal brain metabolism.


Liver Enzyme Bovine Brain Cyanogen Bromide Argininosuccinate Synthetase Brain Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ratner, S., Morell, H. and Carvalho, E., Arch Biochem. Biophys., 91: 280, (1960).PubMedCrossRefGoogle Scholar
  2. 2.
    Allan, J.D., Cusworth, D.C., Dent, C.E., and Wilson, V.K., Lancet, 1: 182; (1958).PubMedCrossRefGoogle Scholar
  3. 3.
    Shih, V.E., and Efron, M.L., in: “The Metabolic Basis of Inherited Disease”, Stanbury, J.B., Wyngaarden, J.B., and Frederickson, D.S., eds., 3rd ed., pp. 370, McGraw-Hill, New York, (1972).Google Scholar
  4. 4.
    Tomilson, S. and Westall, R.G., Nature (London), 188: 235 (1960).CrossRefGoogle Scholar
  5. 5.
    Havir,E.A., Tamir, H., Ratner, S., and Watner, R.C., J. Biol. Chem., 240: 3079, (1965).Google Scholar
  6. 6.
    Schulze, I.T., Lusty, C.J., and Ratner, S., J. Biol. Chem., 245: 4534, (1970).PubMedGoogle Scholar
  7. 7.
    Lusty, C.J., and Ratner, S., J. Biol. Chem., 247: 7010, (1972).PubMedGoogle Scholar
  8. 8.
    Bray, R.C., and Ratner, S., Arch. Biochem. Biophys., 146: 531, (1971).PubMedCrossRefGoogle Scholar
  9. 9.
    Rochovansky, O., J. Biol. Chem., 250: 7225, (1975).PubMedGoogle Scholar
  10. 10.
    Murakami-Murofushi, K., and Ratner, S., Anal. Biochem., 95: 139, (1979).PubMedCrossRefGoogle Scholar
  11. 11.
    Ellman, G., Arch. Biochem. Biophys., 82: 70, (1959).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Kimiko Murakami-Murofushi
    • 1
  • Sarah Ratner
    • 1
  1. 1.Department of BiochemistryThe Public Health Research Institute of The City of New York, Inc.New YorkUSA

Personalised recommendations