A Mechanism for Valproate-Induced Hyperammonemia

  • F. X. Coudé
  • D. Rabier
  • L. Cathelineau
  • G. Grimber
  • P. Parvy
  • P. Kamoun
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 153)


Sodium salt of valproic acid (VPA) is an anticonvulsant which has been successfully used in the treatment of several types of epilepsy, particularly in petit mall. It has been shown recently that VPA induced hyperammonemia in children 2,3. In the search of the mechanism by which VPA inhibits ureagenesis and because of the analogy between some other side effects of VPA and the ketotic hyperglycinemia syndrome (hyperglycinuria 4,5,6 leucopenia 7 and thrombocytopenia 8) we have studied the in vivo and in vitro metabolic effects of VPA on the mitochondrial steps of ureagenesis in rat.


Valproic Acid Urea Cycle Sodium Valproate Methylmalonic Acidemia Carbamyl Phosphate Synthetase 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • F. X. Coudé
    • 1
  • D. Rabier
    • 1
  • L. Cathelineau
    • 1
  • G. Grimber
    • 1
  • P. Parvy
    • 1
  • P. Kamoun
    • 1
  1. 1.Laboratoire de Biochimie GénétiqueHôpital des Enfants MaladesParis Cedex 15France

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