Hyperammonemia in the Neonate with Hypoxia
Inherited defects in enzymes of the urea cycle and those in metabolism of several organic acids and some amino acids can cause neonatal hyperammonemia (Shih, 1978). Ballard et al. (1978) described five newborns with respiratory distress who developed hyperammonemia, but exhibited normal activities of urea cycle enzymes. Similarly significant hyperammonemia in neonates has been reported (Pollack et al., 1978; Le Guennec et al., 1980). Goldberg et al. (1979) have suggested that hyperammonemia may be associated with perinatal asphyxia. These observations would indicate that such hypoxic states as respiratory distress or neonatal asphyxia can cause nonspecific transient hyperammonemia. However, there have been no studies on the relationship between hypoxia and transient hyperammonemia. The relationship between levels of blood ammonia and blood gases was studied to elucidate the role of hypoxia in the pathogenesis of transient hyperammonemia in neonates.
KeywordsRespiratory Distress Urea Cycle Perinatal Asphyxia Base Deficit Blood Ammonia
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