Genetics of Personality Disorders

  • Svenn Torgersen
  • Marco Battaglia


When we wonder about whether genetic factors influence the development of a disorder, we may think about necessary and sufficient conditions for the manifestation of the disorder.
  • Do we need to have some genes to get the disorder, or is it possible to develop the disorder without the genes?

  • Are the genes the full explanation, or do some non-random environmental factors also have to be present?

  • Are genetic factors completely irrelevant, the whole explanation being environmental?

  • Do some genes increase the likelihood of developing the disorder, without being either sufficient or necessary?


Personality Disorder Genetic Influence Twin Study Borderline Personality Disorder Adoption Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Battaglia, M., Bernardeschi, L., Franchini, L., Bellodi, L., and Smeraldi, E. (1995). A family study of Schizo-typal disorder. Schizophrenia Bulletin, 21, 33–45.PubMedCrossRefGoogle Scholar
  2. Battaglia, M., Gasperini, G., Sciuto, G., Scherillo, P, and Bellodi, L. (1991). Psychiatric disorders in the families of schizotypal subjects. Schizophrenia Bulletin, 17, 659–668.PubMedCrossRefGoogle Scholar
  3. Battaglia, M., Przybeck, T.R., Bellodi, L., and Cloninger, C.R. (1996). Temperament dimensions explain the comorbidity of psychiatric disorders. Comprehensive Psychiatry, 37, 292–298.PubMedCrossRefGoogle Scholar
  4. Benjamin, J., Li, L., Patterson, C., Greenberg, B.D., Murphy, D.L., and Hamer, D.H. (1996). Population and familial association between D4 dopamine receptor gene and measures of Novelty Seeking. Nature Genetics, 12, 81–84.PubMedCrossRefGoogle Scholar
  5. Bergeman, C.S., Chipuer, H.M., Plomin, R., Pedersen, N.L., McClearn, G.E., Nesselroade, J.R., Costa, P.T. Jr., and McCrae, R.R. (1993). Genetic and environmental effects on openness to experience, agreeableness, and conscientousness: An adoption/twin study. Journal of Personality, 61, 59–178.CrossRefGoogle Scholar
  6. Cadoret, R.J. (1978). Psychopathology in adopted-away offspring of biologic parents with anti-social behavior. Archives of General Psychiatry, 35, 176–184.PubMedCrossRefGoogle Scholar
  7. Cadoret, R.J. and Stewart, M.A. (1991). An adoption study of attention deficit/hyperactivity/aggression and their relationship to adult antisocial personality. Comprehensive Psychiatry, 32, 73–82.PubMedCrossRefGoogle Scholar
  8. Centerwall, B.S. and Robinette, C.D. (1989). Twin concordance for dishonorable discharge from the military: With a review of the genetics of antisocial behavior. Comprehensive Psychiatry, 30, 442–446.PubMedCrossRefGoogle Scholar
  9. Cloninger, C.R., Adolfsson, R., and Svrakic, N.M. (1996). Mapping genes for human personality. Nature Genetics, 12, 3–4.PubMedCrossRefGoogle Scholar
  10. Cloninger, C.R., Przybeck, T.R., Svrakic, D.M., and Wetzel, R.D. (1994). The Temperament and Character Inventory: a guide to its development and use. St Louis MO, Washington University.Google Scholar
  11. Cloninger, C.R., Sigvardson, S., and Bohman, M. (1982). Predisposition to petty criminality in Swedish adoptees. III Cross-fostering analysis of gene-environment interaction. Archives of General Psychiatry, 39, 1242–1253.PubMedCrossRefGoogle Scholar
  12. Costa, P.T. Jr. and McCrae, R.R. (1990). Personality disorders and the five factor model of personality. Journal of Personality Disorders, 4, 362–371.CrossRefGoogle Scholar
  13. Crowe, R.R. (1974). An adoption study of anti-social personality. Archives of General Psychiatry, 31, 785–791. Dalgard, O.S. and Kringlen, E. (1976). A Norwegian twin study of criminality. The British Journal of Criminology, 16, 213–232.Google Scholar
  14. DeFries, J.C. and Hegmann, J.P. (1970). Genetic analysis of open field behavior. In Contributions to behavior genetic analysis: the mouse as a prototype. Eds G. Lindzey and D.C. Thiessen, pp. 23–56. New York. Appleton Century Crofts.Google Scholar
  15. Eaves, L.J. and Eysenck, H.J. (1975). The nature of extraversion: a genetic analysis. Journal of Personality and Social Psychology, 32, 102–112.PubMedCrossRefGoogle Scholar
  16. Ebstein, R.P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E.R., Nemanov, L., Katz. M., and Belmaker, R.H. (1996). Dopamine D4 receptor exon III polymorphism associated with the human personality trait of Novelty Seeking. Nature Genetics, 12, 78–80.PubMedCrossRefGoogle Scholar
  17. Eysenck, H.J. and Eysenck, S.B.G. (1976). Psychoticism as a dimension of personality. New York: Crane, Russak amp; Co.Google Scholar
  18. Eysenck, H.J. (1967). The biological basis of personality. Springfield, Ill.: Charles C. Thomas.Google Scholar
  19. Goldsmith, H.H. and Gottesman, I.I. (1996). Heritable variability and variable heritability in developmental psychopathology. In M.F. Lenzenweger and J.J. Haugaard (eds): Frontiers of developmental psychopathology. New York, Oxford University Press.Google Scholar
  20. Grove, W.M., Eckert, E.D., Heston, L., Bouchard, T.J. Jr., Segal, N., and Lykken, D.T. (1990). Heritability of substance abuse and antisocial behavior: A study of monozygotic twins reared apart. Biological Psychiatry, 27, 1293–1304.PubMedCrossRefGoogle Scholar
  21. Kendler, K.S. (1995). Genetic epidemiology in psychiatry. Taking both genes and environment seriously. Archives of General Psychiatry, 52, 895–899.PubMedCrossRefGoogle Scholar
  22. Kendler, K.S., McGuire, M., Gruenberg, A.M., O’Hare, A., Spellman, M., and Walsh, D. (1993). The Roscommon family study. I Methods, Diagnosis of probands and risks for schizophrenia in relatives. Archives of General Psychiatry, 50, 527–540.PubMedCrossRefGoogle Scholar
  23. Kendler, H.S., Gruenberg, A.M., and Kinney, D.K. (1994). Independent diagnoses of adoptees and relatives as defined by DSM-III in the Provincial and National sample of the Danish Adoption Study of Schizophrenia. Archives of General Psychiatry, 51, 456–468.PubMedCrossRefGoogle Scholar
  24. Kendler, K.S. and Hewitt, J.K. (1992). The structure of self-report schizotypi in twins. Journal of Personality Disorders, 6, 1–17.CrossRefGoogle Scholar
  25. Kendler, K.S., Heath, A., and Martin, N.G. (1987). A genetic epidemiologic study of self-report suspiciousness. Comprehensive Psychiatry, 28, 187–196.PubMedCrossRefGoogle Scholar
  26. Lesch, K.E, Bengel, D., Heils, A., Sabol, S.Z., Greenberg, B.D., Petri, S., Benjamin, J., Muller, C.R., Hamer, D.H., and Murphy, D.L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527–1531.Google Scholar
  27. Livesley, W.J., Jang, K.L., Jackson, D.N., and Vernon, P.A. (1993). Genetic and environmental contributions to dimensions of personality disorder. American Journal of Psychiatry, 150, 1826–1831.PubMedGoogle Scholar
  28. Lyons, M.J., True, W.R., Eisen, S.A., Goldberg, J., Meyer, J.M., Faraone, S.M., Eaves, L.J., and Tsuang, M.T. (1995). Differential heritability of adult and juvenile antisocial traits. Archives of General Psychiatry, 52, 906–915.PubMedCrossRefGoogle Scholar
  29. McGuffin, P. and Gottesman, I.I. (1984). Genetic influence on normal and abnormal development. In: M. Rutter and L. Hersou (Eds.). Child Psychiatry: Modern Approaches ( 2nd ed.) London: Blackwell.Google Scholar
  30. McCrae, R.R. and Costa, P.T. Jr. (1987). Validation of the five-factor model of personality across instruments and observers. Journal of Personality and Social Psychology, 52, 81–90.PubMedCrossRefGoogle Scholar
  31. Pedersen, N.L., McClearn, G.E., Plomin, R., Nesselroade, J.R., Berg, S., and De Faire, U. (1991). The Swedish Adoption/Twin Study of Ageing: An update. Acta Geneticae Medicae et Gemellologiae, 40, 7–20.PubMedGoogle Scholar
  32. Perry, J.C. (1992). Problems and considerations in the valid assessment of personality disorders. American Journal of Psychiatry, 149, 1645–1653.PubMedGoogle Scholar
  33. Plomin, R., De Fries, J.C., and McClearn, G.E. (1990). Behavioral Genetics. A primer. Second Edition WH Freeman amp; Co., New York.Google Scholar
  34. Sigvardson, S., Cloninger, C.R., and Bohman, M. (1982). Predisposition to petty criminality in Swedish adoptees III. Sex differences and validation of the male typology. Archives of General Psychiatry, 39, 1248–1253.CrossRefGoogle Scholar
  35. Soldz, S., Budman, S., Demby, A., and Merry, J. (1993). Representation of personality disorders in circumplex and five-factor space: Exploration with a clinical sample. Psychological Assessment, 5, 41–52.CrossRefGoogle Scholar
  36. Stallings, M.C., Hewitt, J.K., Cloninger, C.R., Heath, A.C., and Eaves, L.J. (1994). The structure of temperament: a joint analysis of the models of Cloninger, Eysenck, and Gray. Behavior Genetics 24 (6), 532.Google Scholar
  37. Straub, R.E., MacLean, C:J., O’Neill, F.A., Burke, J., Murphy, B., Duke, E, Shinkwin, R., Webb, B.T., Zhang, J., Walsh, D., and Kendler, K.S. (1995). A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity. Nature Genetics 11, 287–293.Google Scholar
  38. Tellegen, A. (1983). Structure of mood and personality, and their relevance to assessing anxiety, with an emphasis on self-report. In: A.H. Tuma and J.D. Maser (Eds.). Anxiety and the anxiety disorders (pp. 681–706 ). Hillsdale, NJ: Erlbaum.Google Scholar
  39. Tellegen, A., Lykken, T.D., Bouchard, T.J., Wilcox, K.J., Segal, N.L., and Rich, S. (1988). Personality similarity in twins reared apart and together. Journal of Personality and Social Psychology, 54, 1031–1039.PubMedCrossRefGoogle Scholar
  40. Torgersen, S. (1984). Genetic and nosological aspects of schizotypal and borderline personality disorders. A twin study. Archives of General Psychiatry, 41, 546–554.PubMedCrossRefGoogle Scholar
  41. Torgersen, S., Skre, I, Onstad, S., Edvardsen, I., and Kringlen, E. (1993b). “True” schizotypal personality disorder: A study of co-twins and relatives of schizophrenic probands. American Journal of Psychiatry, 150,1661–1667.Google Scholar
  42. Torgersen, S., Skre, I., Onstad, S., Edvardsen, J., and Kringlen, E. (1993a). The psychometric-genetic structure of DSM-III-R personality disorder criteria. Journal of Personality Disorders, 7, 196–213.CrossRefGoogle Scholar
  43. Trull, T.J. (1992). DSM-III-R personality disorders and the five-factor model of personality: An empirical comparison. Journal of Abnormal Psychology, 101, 553–560.PubMedCrossRefGoogle Scholar
  44. Zimmermann, M. (1994). Diagnosing personality disorders. A review of issues and research methods. Archives of General Psychiatry, 51, 225–242.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Svenn Torgersen
    • 1
  • Marco Battaglia
    • 2
  1. 1.Department of PsychologyUniversity of OsloOsloNorway
  2. 2.Department of Neuropsychiatric SciencesUniversity of Milano and the San Raffaele HospitalMilanoItaly

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