Immunology pp 123-140 | Cite as

Role of the Reticuloendothelial System in T-Helper Cell Induction

  • David R. Katz
  • Geoffrey H. Sunshine
  • Marc Feldmann
  • Peter Erb


The development of in vitro culture systems and cell separation methods has provoked increasing interest in understanding the role of RES accessory cells (AC) in immune induction. As the relevant technology was improved, AC were found to be important in every immune function assayed, such as antibody production in vitro (Mosier, 1969), killer cell induction (Wagner et al., 1972), mixed leukocyte reaction (MLR) (Greineder and Rosenthal, 1975), T-cell proliferation (Rosenwasser and Rosenthal, 1978), etc. Apparent exceptions early on (Diener et al., 1970) were almost certainly reflections of the different types and numbers of AC required for various responses, and also of the inefficiency of AC depletion by conventional adherence procedures which are usually only maintained for the depletion of classical macrophages. Accordingly we were not surprised that T-cell help in vitro required macrophages (Erb and Feldmann, 1975a) .


Accessory Cell Chimeric Mouse Soluble Antigen Peritoneal Exudate Cell Mixed Leukocyte Reaction 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • David R. Katz
    • 1
  • Geoffrey H. Sunshine
    • 1
  • Marc Feldmann
    • 1
  • Peter Erb
    • 2
  1. 1.Imperial Cancer Research Fund, Tumour Immunology Unit, Department of ZoologyUniversity College LondonLondonEngland
  2. 2.Institute for Microbiology and HygieneThe University of BaselBaselSwitzerland

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