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Immunology pp 113–121Cite as

The Role of Mononuclear Phagocytes as Accessory Cells in Lymphocyte Responses

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Abstract

For some time it has been known that certain immunologic functions of lymphocytes require the addition of mononuclear phagocytes in order to be operative. Historically, Mosier and Coppleson (1968) initially described a need for adherent cells in animal in vitro primary immune responses. As the supportive role of adherent cells in immune responses became apparent, efforts were made to identify the lineage of this accessory cell. The evidence to date indicates that although a number of cells can function as accessory cells, mononuclear phagocytes are the predominant accessory cell type operational in many current immunologic assay systems. Mononuclear phagocytes have been employed as accessory cells in both their blood monocyte and tissue macrophage forms; both animal and human research systems abound.

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Author information

Authors and Affiliations

  1. Clinical Investigations Section, Biologic Response Modifiers Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland, 21701, USA

    Henry C. Stevenson

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  1. Henry C. Stevenson
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Editors and Affiliations

  1. Georgetown University School of Medicine, Washington, D.C., USA

    Joseph A. Bellanti

  2. Georgetown University Schools of Medicine and Dentistry, Washington, D.C., USA

    Herbert B. Herscowitz

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© 1984 Springer Science+Business Media New York

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Stevenson, H.C. (1984). The Role of Mononuclear Phagocytes as Accessory Cells in Lymphocyte Responses. In: Bellanti, J.A., Herscowitz, H.B. (eds) Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6784-1_7

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  • DOI: https://doi.org/10.1007/978-1-4757-6784-1_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6786-5

  • Online ISBN: 978-1-4757-6784-1

  • eBook Packages: Springer Book Archive

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