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Utilization of Monoclonal Antibodies in the Characterization of Monocyte-Macrophage Differentiation Antigens

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Immunology

Abstract

Cells of the monocyte-macrophage lineage perform diverse functions ranging from phagocytosis of microorganisms and other foreign substances, killing of antibody-coated erythrocytes or tumor cells (antibody-dependent cellular cytotoxicity, ADCC) (Poplack et al., 1976; Levy et al., 1979), spontaneous killing of unsensitized tumor cells (natural killing, NK) (Mantovani et al., 1979; de Vries et al., 1980; and Fischer et al., 1981), uptake and presentation of antigenic material in a form that is stimulatory to helper T lymphocytes (Unanue, 1978), suppression of immune responses (Allison, 1978), and secretion of certain complement components and other stimulatory products (Nathan et al., 1980; Beatty et al., 1981).

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Authors and Affiliations

  1. Division of Tumor Immunology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Robert F. Todd III & Stuart F. Schlossman

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  1. Robert F. Todd III
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  1. Georgetown University School of Medicine, Washington, D.C., USA

    Joseph A. Bellanti

  2. Georgetown University Schools of Medicine and Dentistry, Washington, D.C., USA

    Herbert B. Herscowitz

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Todd, R.F., Schlossman, S.F. (1984). Utilization of Monoclonal Antibodies in the Characterization of Monocyte-Macrophage Differentiation Antigens. In: Bellanti, J.A., Herscowitz, H.B. (eds) Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6784-1_6

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