Immunology pp 87-112 | Cite as

Utilization of Monoclonal Antibodies in the Characterization of Monocyte-Macrophage Differentiation Antigens

  • Robert F. ToddIII
  • Stuart F. Schlossman


Cells of the monocyte-macrophage lineage perform diverse functions ranging from phagocytosis of microorganisms and other foreign substances, killing of antibody-coated erythrocytes or tumor cells (antibody-dependent cellular cytotoxicity, ADCC) (Poplack et al., 1976; Levy et al., 1979), spontaneous killing of unsensitized tumor cells (natural killing, NK) (Mantovani et al., 1979; de Vries et al., 1980; and Fischer et al., 1981), uptake and presentation of antigenic material in a form that is stimulatory to helper T lymphocytes (Unanue, 1978), suppression of immune responses (Allison, 1978), and secretion of certain complement components and other stimulatory products (Nathan et al., 1980; Beatty et al., 1981).


Bone Marrow Cell Peritoneal Macrophage Human Monocyte Acute Myelogenous Leukemia Peripheral Blood Monocyte 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Robert F. ToddIII
    • 1
  • Stuart F. Schlossman
    • 1
  1. 1.Division of Tumor Immunology, Dana-Farber Cancer Institute, and Department of MedicineHarvard Medical SchoolBostonUSA

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