Skip to main content
SpringerLink
Log in

Immune Functions of Dendritic-Type Cells

  • Chapter
Immunology

Abstract

Over the last several years considerable evidence has accumulated indicating that cells with a dendritic morphology play important roles in a variety of immune functions. A list of the immunologically relevant dendritic-type cells (D cells) and the immune functions associated with each is presented in Table 1. As indicated in the footnotes in this table, a number of names have been used to describe and identify different D cells. The names and abbreviations used in the body of this table have been tentatively agreed upon by the RES committee on nomenclature.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Britton, S. T., Wepsic, T., and Moller, G., 1968, Persistence of immunogenicity of two complex antigens retained in vivo, Immunology 14:491.

    PubMed  CAS  Google Scholar 

  • Bystryn, J. C., Graf, M. W., and Uhr, J. W., 1970, Regulation of antibody formation by serum antibody. II. Removal of specific antibody by means of exchange transfusion, J. Exp. Med. 132:1279.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, D., and Garvey, J., 1963, Nature of retained antigen and its role in immune mechanisms, in: Advances in Immunology (F. J. Dixon and J. H. Humphrey, eds.), pp. 261–313, Academic Press, New York.

    Google Scholar 

  • Caputo, R., Deluchetti, D., and Monti, M., 1976, Freeze-fracture of Langerhans granules: A comparative study, J. Invest. Dermatol. 66:297.

    Article  PubMed  CAS  Google Scholar 

  • Cerottini, J. C., and Trnka, Z., 1970, The role of persisting antigen in the development of immunological memory, Int. Arch. Allergy Appl. Immunol. 38:37.

    Article  PubMed  CAS  Google Scholar 

  • Chen, L. L., Adams, J. C., and Steinman, R. M., 1978, Anatomy of germinal centers in mouse spleen, with special reference to “follicular dendritic cells”, J. Cell Biol. 77:148.

    Article  PubMed  CAS  Google Scholar 

  • Elliott, L. H., and Roszman, T. L., 1975, Antigenic selection of IgG precursor populations, J. Immunol. 115:495.

    PubMed  CAS  Google Scholar 

  • Ford, W. L., and Gowans, J., 1967, The role of lymphocytes in antibody formation. II. The influence of lymphocyte migration on the initiation of antibody formation in the isolated perfused spleen, Proc. R. Soc. London Ser. B 168:244.

    Article  CAS  Google Scholar 

  • Franzl, R., 1962, The primary immune response in mice. III. Retention of sheep red blood cell immunogens by the spleen, Infect. Immun. 6:469.

    Google Scholar 

  • Gowans, J., 1962, The fate of parental strain small lymphocytes in F1 hybrid rats, Ann. N.Y. Acad. Sci. 99:432.

    Article  PubMed  CAS  Google Scholar 

  • Greene, M. I., Sugimoto, M., and Benacerraf, B., 1978, Mechanisms of regulation of cell-mediated immune responses. I. Effect of the route of immunization with TNP-coupled syngeneic cells on the induction and suppression of contact sensitivity to picryl chloride, J. Immunol. 120:1604.

    PubMed  CAS  Google Scholar 

  • Hanna, M. G., Jr., and Szakal, A. K., 1968, Localization of 125I-labeled antigen in germinal centers of mouse spleen: Histologic and ultrastructural autoradiographic studies of the secondary immune reaction, J. Immunol. 101:949.

    PubMed  Google Scholar 

  • Hanna, M. G., Jr., Makinodan, T., and Fisher, W. D., 1967, Lymphatic tissue germinal center localization of 125I-labeled heterologous and isologous macroglobulins, in: Germinal Centers in Immune Responses (H. Cottier, N. Odartchenko, R. Schindler, and C. C. Congdon), p. 86, Springer-Verlag, Berlin.

    Chapter  Google Scholar 

  • Hawn, C., and Janeway, C., 1947, Histological and serological sequences in experimental hypersensitivity, J. Exp. Med. 85:571.

    Article  PubMed  CAS  Google Scholar 

  • Hoffman, M. K., 1980, Antibody regulates the cooperation of B-cells with helper cells, Immunol. Rev. 49:79.

    Article  Google Scholar 

  • Humphrey, J. H., and Frank, M. M., 1967, The localization of nonmicrobial antigens in the draining lymph nodes of tolerant, normal and primed rabbits, Immunology 13:87.

    PubMed  CAS  Google Scholar 

  • Kaplan, M. H., Coons, A. H., and Deane, H. W., 1950, Localization of antigen in tissue cells. III. Cellular distribution of pneumococcal polysaccharide type II and III in the mouse, J. Exp. Med. 91:15.

    Article  PubMed  CAS  Google Scholar 

  • Kitces, E. N., Tew, J. G., and Greene, E. J., 1975, Induction and maintenance of antibody responses by different forms of human serum albumin, Immunol. Commun. 4:275.

    PubMed  CAS  Google Scholar 

  • Klaus, G. G. B., 1979, The generation of memory cells. III. Antibody class requirements for the generation of B-memory cells by antigen—antibody complexes, Immunology 37:345.

    PubMed  CAS  Google Scholar 

  • Klaus, G. G. B., and Humphrey, J. H., 1977, The generation of memory cells. I. The role of C3 in the generation of B memory cells, Immunology 33:31.

    PubMed  CAS  Google Scholar 

  • Klaus, G. G. B., Humphrey, J. H., Kunkl, A., and Dongworth, D. W., 1980, The follicular dendritic cell: Its role in antigen presentation in the generation of immunological memory, Immunol. Rev. 53:3.

    Article  PubMed  CAS  Google Scholar 

  • Klinkert, W. E. F., Labadie, J. H., O’Brien, J. P., Beyer, D. F., and Powers, W. E., 1980, Rat dendritic cells function as accessory cells and control the production of a soluble factor required for mitogenic responses of T lymphocytes, Proc. Natl. Acad. Sci. USA 77:5414.

    Article  PubMed  CAS  Google Scholar 

  • Kuntz, M. M., Innes, J. B., and Weksler, M. E., 1976, Lymphocyte transformation induced by autologous cells. IV. Human T-lymphocyte proliferation induced by autologous or all geneic non-T lymphocytes, J. Exp. Med. 143:1043.

    Article  Google Scholar 

  • Lafferty, K., and Woolnough, J., 1977, The origin and mechanism of allograft rejection, Immunol. Rev. 35:231.

    Article  PubMed  CAS  Google Scholar 

  • Laissue, J., Cotlier, H., Hess, M. W., and Stoner, R. D., 1971, Early and enhanced germinal center formation and antibody responses after primary stimulation with antigen—isologous antibody complexes as compared with antigen alone, J. Immunol. 107:822.

    PubMed  CAS  Google Scholar 

  • Langerhans, P., 1868, Uber die nerven der menschlichen haut, Virchows Arch. A 44:325.

    Article  Google Scholar 

  • Mandel, T. E., Phipps, R. P., Abbot, A. P., and Tew, J. G., 1980, The follicular dendritic cell: Long term antigen retention during immunity, Immunol. Rev. 53:29.

    Article  PubMed  CAS  Google Scholar 

  • Mandel, T. E., Phipps, R. P., Abbot, A. P., and Tew, J. G., 1981, Long term antigen retention by follicular dendritic cells in the popliteal lymph node of immunized mice, Immunology 43:353.

    PubMed  CAS  Google Scholar 

  • Nettesheim, P., and Hammons, A. S., 1970, Effect of immunosuppressive agents on retention of antigen in the mouse spleen, Proc. Soc. Exp. Biol. Med. 133:696.

    Article  PubMed  CAS  Google Scholar 

  • Nossal, G. J. V., and Ada, G., 1971, Antigens, Lymphoid Cells and the Immune Response, Academic Press, New York.

    Google Scholar 

  • Nossal, G. J. V., Abbot, A., Mitchell, J., and Lummus, Z., 1968, Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles, J. Exp. Med. 127:277.

    Article  PubMed  CAS  Google Scholar 

  • Nussenzweig, M. C., and Steinman, R. M., 1980, Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction, J. Exp. Med. 151:1196.

    Article  PubMed  CAS  Google Scholar 

  • Nussenzweig, M. C., Steinman, R. M., Gutchinov, B., and Cohn, Z. A., 1980, Dendritic cells are accessory cells for the generation of anti-TNP cytotoxic T cells, J. Exp. Med. 152:1070.

    Article  PubMed  CAS  Google Scholar 

  • Nussenzweig, M. C., Steinman, R. M., Unkeless, J. C., Witmer, M. D., Gutchinov, B., and Cohn, Z., 1981, Studies of the cell surface of mouse dendritic cells and other leukocytes, J. Exp. Med. 154:168.

    Article  PubMed  CAS  Google Scholar 

  • O’Brien, R. L., and Parker, J. W., 1976, Oxidation-induced lymphocyte transformation, Cell 7:13.

    Article  PubMed  Google Scholar 

  • Phillips, M. L., Parker, J. A., Frelinger, J. A., and O’Brien, R. L., 1980, Characterization of responding cells in oxidative mitogen stimulation. II. Identification of an Ia-bearing adherent accessory cell, J. Immunol. 124:2700.

    PubMed  CAS  Google Scholar 

  • Phipps, R. P., Mitchell, G. F., Mandel, T. E., and Tew, J. G., 1980, Antibody isotypes mediating antigen retention in passively immunized mice, Immunology 40:459.

    PubMed  CAS  Google Scholar 

  • Phipps, R. P., Mandel, T. E., and Tew, J. G., 1981, Effect of immunosuppressive agents on antigen retained in lymphoid follicles and collagenous tissue of immune mice, Cell. Immunol. 57:505.

    Article  PubMed  CAS  Google Scholar 

  • Ponzio, N. M., Chapman-Alexander, J. M., and Thorbecke, G. J., 1977, Transfer of memory cells into antigen pretreated hosts. I. Functional detection of migration sites for antigen-specific B-cells, Cell. Immunol. 34:79.

    Article  PubMed  CAS  Google Scholar 

  • Ponzio, N. M., Baine, Y., and Thorbecke, G. J., 1980, Localization of functional memory B cells at sites of antigen localization and its relationship to local aspects of immunological memory, in: Phylogeny of Immunological Memory (M. J. Manning, ed.), p. 291, Elsevier, North-Holland.

    Google Scholar 

  • Ptak, W., Rozycka, D., Askenase, P. W., and Gershon, R. K., 1980, Role of antigen-presenting cells in the development and persistence of contact hypersensitivity, J. Exp. Med. 151:362.

    Article  PubMed  CAS  Google Scholar 

  • Richter, M., Zimmerman, S., and Haurowitz, F., 1965, Relation of antibody titre to persistence of antigen, J. Immunol. 94:938.

    PubMed  CAS  Google Scholar 

  • Shelley, W. B., and Juhlin, L., 1976, Langerhans cells form a reticuloepithelial trap for external contact allergens, Nature (London) 261:46.

    Article  CAS  Google Scholar 

  • Shelley, W. B., and Juhlin, L., 1977, Selective uptake of contact allergens by the Langerhans cells, Arch. Dermatol. 113:187.

    Article  PubMed  CAS  Google Scholar 

  • Sherr, D. J., and Siskind, G. W., 1977, Studies on the control of antibody synthesis. XI. Effect of antigen on the localization of cells secreting different avidity antibody, Proc. Soc. Exp. Biol. Med. 155:203.

    Article  PubMed  CAS  Google Scholar 

  • Silberberg-Sinakin, I., Baer, R. L., and Thorbecke, J. G., 1980, Langerhana Cells: Role in contact hypersensitivity and relationship to lymphoid dendritic cells and to macrophages, Immunol. Rev., 53:203.

    Article  PubMed  CAS  Google Scholar 

  • Silberberg, I., 1973, Apposition of mononuclear cells to Langerhans cells in contact allergic reactions: An ultrastructural study, Acta Derm. Venereol. 53:1.

    PubMed  CAS  Google Scholar 

  • Silberberg-Sinakin, I., and Thorbecke, G. J., 1976, Contact hypersensitivity and Langerhans cells, J. Invest. Dermatol. 75:61.

    Article  Google Scholar 

  • Silberberg-Sinakin, I., Thorbecke, G. J., Baer, R. L., Rosenthal, S. A., and Berezowsky, V., 1976, Antigen-bearing Langerhans cells in skin dermal lymphatics and in lymph nodes, Cell. Immunol. 25:137.

    Article  PubMed  CAS  Google Scholar 

  • Silberberg-Sinakin, I., Fecorko, M. E., Baer, R. L., Rosenthal, S. A., Berezowsky, V., and Thorbecke, G. J., 1977, Langerhans cells: Target cells in immune complex reactions, Cell. Immunol. 32:400.

    Article  PubMed  CAS  Google Scholar 

  • Sordat, B., Sordat, M., Hess, M. W., Stona, R. D., and Cottier, J., 1970, Specific antibody within lymphoid germinal center cells in mice after primary immunization with horseradish peroxidase: A light and electron microscopic study, J. Exp. Med. 131:77.

    Article  PubMed  CAS  Google Scholar 

  • Steinman, R. M., and Cohn, Z. A., 1973, Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution, J. Exp. Med, 137:1142.

    Article  PubMed  CAS  Google Scholar 

  • Steinman, R. M., and Cohn, Z. A., 1974, Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro, J. Exp. Med. 139:380.

    Article  CAS  Google Scholar 

  • Steinman, R. M., and Cohn, Z. A., 1975, Dendritic cells, reticular cells, and macrophages, in: Mononuclear Phagocytes (R. van Furth, ed.), p. 95, Blackwell, London.

    Google Scholar 

  • Steinman, R. M., and Nussenzweig, M. C., 1980, Dendritic cells: Features and functions, Immunol. Rev. 53:127.

    Article  PubMed  CAS  Google Scholar 

  • Steinman, R. M., and Witmer, M., 1978, Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice, Proc. Natl. Acad. Sci. USA 75:5132.

    Article  PubMed  CAS  Google Scholar 

  • Steinman, R. M., Lustig, D. S., and Cohn, Z. A., 1974, Identification of a novel cell type in peripheral lymphoid organs of mice. III. Functional properties in vivo, J. Exp. Med. 139:1431.

    Article  PubMed  CAS  Google Scholar 

  • Steinman, R. M., Kaplan, G., Witmer, M., and Cohn, Z. A., 1979, Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, maintenance in vitro and new surface markers of dendritic cells. J. Exp. Med. 149:1.

    Article  PubMed  CAS  Google Scholar 

  • Stingl, G., Wolff-Schreiner, E. C., Pichler, W. J., Eschnait, F., Knapp, W., and Wolff, K., 1977, Epidermal Langerhans cells bear Fc and C3 receptors, Nature (London) 268:245.

    Article  CAS  Google Scholar 

  • Stingl, G., Katz, S., Clement, L., Green, I., and Shevach, E. M., 1978a, Immunologic functions of Iabearing epidermal Langerhans cells, J. Immunol. 131:2005.

    Google Scholar 

  • Stingl, G., Katz, S. I., Shevach, E. M., Wolff-Schreiner, E. C., and Green, I., 1978b, Detection of Ia antigens on Langerhans cells in guinea pig skin, J. Immunol. 120:570.

    PubMed  CAS  Google Scholar 

  • Stingl, G., Tamaki, K., and Katz, S., 1980, Origin and function of Langerhans cells, Immunol. Rev. 53:149.

    Article  PubMed  CAS  Google Scholar 

  • Stockinger, B., and Lemmel, E., 1978, On the mechanism of antibody-mediated feedback regulation: Lack of inhibition in Fc receptor negative cells, Cell. Immunol. 40:395.

    Article  PubMed  CAS  Google Scholar 

  • Sunshine, G. H., Katz, D. R., and Feldman, M., 1980, Dendritic cells induce T-cell proliferation to synthetic antigens under Ir gene control, J. Exp. Med. 152:1817.

    Article  PubMed  CAS  Google Scholar 

  • Szakal, A. K., and Hanna, M. G., Jr., 1968, The ultrastructure of antigen localization and virus-like particles in mouse spleen germinal centers, Exp. Mol. Pathol. 8:75.

    Article  PubMed  CAS  Google Scholar 

  • Talmage, D., Dixon, F., Bukantz, S., and Dammin, C., 1951, Antigen elimination from the blood as an early manifestation of the immune response, J. Immunol. 67:243.

    PubMed  CAS  Google Scholar 

  • Tew, J. G., and Mandel, T. E., 1978, The maintenance and regulation of serum antibody levels: Evidence indicating a role for antigen retained in lymphoid follicles, J. Immunol. 120:1063.

    PubMed  CAS  Google Scholar 

  • Tew, J. G., and Mandel, T. E., 1979, Prolonged antigen half life in the lymphoid follicles of specifically immunized mice, Immunology 37:67.

    Google Scholar 

  • Tew, J. G., Self, C. H., Harold, W. W., and Stavitsky, A. B., 1973, The spontaneous induction of anamnestic antibody synthesis in lymph node cell cultures many months after primary immunization, J. Immunol. 111:416.

    PubMed  CAS  Google Scholar 

  • Tew, J. G., Mandel, T. E., and Burgess, A. W., 1979a, Retention of intact HSA for prolonged periods in the popliteal lymph nodes of specifically immunized mice, Cell. Immunol. 45:207.

    Article  PubMed  CAS  Google Scholar 

  • Tew, J. G., Mandel, T. E., and Miller, G. A., 1979b, Immune retention: Immunological requirements for maintaining an easily degradable antigen in vivo, Aust. J. Exp. Biol. Med. Sci. 57:401.

    Article  PubMed  CAS  Google Scholar 

  • Tew, J. G., Phipps, R. P., and Mandel, T. E., 1980a, The maintenance and regulation of the humoral immune response: Persisting antigen and the role of follicular antigen binding dendritic cells as accessory cells, Immunol. Rev. 53:175.

    Article  PubMed  CAS  Google Scholar 

  • Tew, J. G., Mandel, T. E., and Rice, P. L., 1980b, Immune elimination and immune retention: The relationship between antigen retained in the foot and the elicitation of footpad swelling, Immunology 40:425.

    PubMed  CAS  Google Scholar 

  • Toews, G. B., Bergstresser, P. R., and Streilein, J. W., 1980, Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB, J. Immunol. 124:445.

    PubMed  CAS  Google Scholar 

  • Van Rooijen, N., 1972, Antigens in the spleen: The non-specificity of the follicles in the process of antigen trapping and the role of antibody, Immunology 22:757.

    PubMed  Google Scholar 

  • Voisen, G. A., 1980, Role of antibody classes in the regulatory facilitation reaction, Immunol. Rev. 49:3.

    Article  Google Scholar 

  • Weigle, W. O., 1975, Cyclical production of antibody as a regulatory mechanism in immune responses, Adv. Immunol. 21:87.

    Article  PubMed  CAS  Google Scholar 

  • White, R. G., 1963, Functional Recognition of Immunologically Competent Cells by Means of the Fluorescent Antibody Technique, Ciba Found. Study Group No. 16, p. 6.

    Google Scholar 

  • White, R. G., French, V. I., and Stark, J. M., 1967, Germinal center formation and antigen localization in Malpighian bodies of the chicken spleen, in: Germinal Centers in Immune Responses (H. Cotlier, N. Odontchenki, R. Schindler, and C. C. Congdon, eds.), p. 131, Springer-Verlag, Berlin.

    Chapter  Google Scholar 

  • Wolff, K., 1972, The Langerhans cell, in: Current Problems in Dermatology (J. W. J. Mali, ed.), Vol. 4, p. 79, Karger, Basel.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, 23298, USA

    John G. Tew & Richard P. Phipps

Authors
  1. John G. Tew
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Richard P. Phipps
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Georgetown University School of Medicine, Washington, D.C., USA

    Joseph A. Bellanti

  2. Georgetown University Schools of Medicine and Dentistry, Washington, D.C., USA

    Herbert B. Herscowitz

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer Science+Business Media New York

About this chapter

Cite this chapter

Tew, J.G., Phipps, R.P. (1984). Immune Functions of Dendritic-Type Cells. In: Bellanti, J.A., Herscowitz, H.B. (eds) Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6784-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6784-1_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6786-5

  • Online ISBN: 978-1-4757-6784-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation