Skip to main content
SpringerLink
Log in
Book cover

Immunology pp 43–66Cite as

Differentiation and Functional Regulation in Macrophage Cell Lines

  • Chapter

  • 434 Accesses

Abstract

Macrophage-related cell lines offer many advantages for the study of macrophage function (Table 1). These advantages range from convenience in obtaining large numbers of cells of relatively homogenous nature by growth in culture, to purity of the cell population ensuring that experimental results obtained are due only to macrophages. A variety of cell lines and variants exist which stably differ in degree of maturation, sensitivity to inducing agents, and extent of mature macrophage characteristics. Since the cell lines are growing rapidly, it is relatively easy to synchronize or select cells at different stages of the cell cycle for study of physiological functions throughout the cell division process.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aksamit, R. R., and Kim, K. J., 1979, Macrophage cell lines produce a cytotoxin, J. Immunol. 122:1785.

    PubMed  CAS  Google Scholar 

  • Aksamit, R. R., Falk, W., and Leonard, E. J., 1981, Chemotaxis by mouse macrophage cell lines, J. Immunol. 126:2194.

    PubMed  CAS  Google Scholar 

  • Arene, T., and Pierce, C., 1980, Properties of a nonspecific suppressor factor produced by SIRS-treated macrophages, Fed. Proc. 39:1156A.

    Google Scholar 

  • Ascensao, J. L., Kay, N. E., Earenfight-Engler, T., Koren, H. S., and Zanjani, E. D., 1981, Production of erythroid potentiating factor(s) by a human monocytic cell line, Blood 57:170.

    PubMed  CAS  Google Scholar 

  • Ault, K. A., and Springer, T. A., 1981, Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells, J. Immunol. 126:359.

    PubMed  CAS  Google Scholar 

  • Bar, R. S., Kahn, C. R., and Koren, H. S., 1977, Insulin inhibition of antibody-dependent cytotoxicity and insulin receptors in macrophages, Nature (London) 265:632.

    Article  CAS  Google Scholar 

  • Berens, R. L., and Marr, J. J., 1979, Growth of Leishmania donovani amastigotes in a continuous macrophage-like cell culture, J. Protozool. 26:453.

    PubMed  CAS  Google Scholar 

  • Berlin, R. D., Oliver, J. M., and Walter, R. J., 1978. Surface functions during mitosis: Phagocytosis, pinocytosis and mobility of surface-bound Con A, Cell 15:327.

    Article  PubMed  CAS  Google Scholar 

  • Bodel, P., 1978, Spontaneous pyrogen production by mouse histiocytic and myelomonocytic tumor cell lines in vitro, J. Exp. Med. 147:1503.

    PubMed  CAS  Google Scholar 

  • Bodel, P., Ralph, P., Wenc, K., and Long, J. C., 1980, Endogenous pyrogen production by Hodgkin’s disease and human histiocytic lymphoma cell lines in vitro, J. Clin. Invest. 65:514.

    Article  PubMed  CAS  Google Scholar 

  • Boyse, E. A., and Old, L. J., 1969, Some aspects of normal and abnormal cell surface genetics, Annu. Rev. Genet. 3:269.

    Article  Google Scholar 

  • Bradley, T. R., Pilkington, G., Garson, M., Hodgson, G. S., and Kraft, N., 1982, Cell lines derived from a human myelomonocytic leukaemia, Br. J. Haematol. 51:595.

    Article  PubMed  CAS  Google Scholar 

  • Broxmeyer, H. E., and Ralph, P., 1977, In vitro regulation of a mouse myelomonocytic leukemia line in culture, Cancer Res. 37:3578.

    PubMed  CAS  Google Scholar 

  • Broxmeyer, H. E., Bognacki, J., Ralph, P., Dorner, M. H., Li, L., and Castro-Malaspina, H., 1982, Monocyte-macrophage derived acidic isoferritins: Normal feedback regulators of granulocytemacrophage progenitor cells, Blood 60:595.

    PubMed  CAS  Google Scholar 

  • Burgess, A. W., and Metcalf, D., 1980, Characterization of a serum factor stimulating the differentiation of myelomonocytic leukemic cells, Int. J. Cancer 26:647.

    Article  PubMed  CAS  Google Scholar 

  • Cahoon, B. E., and Mills, J., 1981, Development and characterization of a continuous line of alveolar macrophages from C3H/HeJ mice, J. Reticuloendothelial Soc. 29:357.

    CAS  Google Scholar 

  • Chang, K.-P., 1980, Human cutaneous Leishmania in a mouse macrophage line: Propagation and isolation of intracellular parasites, Science 209:1240.

    Article  PubMed  CAS  Google Scholar 

  • Damian, G., Kiyotaki, C., Soeller, W., Sasada, M., Peisach, J., and Bloom, B. R., 1980, Macrophage variants in oxygen metabolism, J. Exp. Med. 152:808.

    Article  Google Scholar 

  • Diamond, B., and Yelton, D. E., 1981, A new Fc receptor on mouse macrophages binding IgG3, J. Exp. Med. 153:514.

    Article  PubMed  CAS  Google Scholar 

  • Diamond, B., Bloom, B. R., and Scharff, M. D., 1978, The Fc receptors of primary and cultured phagocytic cells studied with homogeneous antibodies, J. Immunol. 121:1329.

    PubMed  CAS  Google Scholar 

  • Djeu, J. Y., Heinbaugh, J. A., Holden, H. T., and Herberman, R. B., 1979, Role of macrophages in the augmentation of mouse natural killer cell activity by poly I : C and interferon, J. Immunol. 122:182.

    PubMed  CAS  Google Scholar 

  • Edelson, P. J., 1981, Plasma membrane ectoenzymes: Macrophage differentiation antigens, in: Heterogeneity of Mononuclear Phagocytes (O. Forster and M. Landy, eds.), pp. 143–149, Academic Press, New York.

    Google Scholar 

  • Farrar, J. J., Mizel, S. B., Fuller-Farrar, J., Farrar, W. L., and Hilfiker, M. L., 1980, Macrophageindependent activation of helper T cells. I. Production of interleukin 2, J. Immunol. 125:793.

    PubMed  CAS  Google Scholar 

  • Gidlung, M., Orn, A., Pattengale, P. K., Jannson, M., Wigzell, H., and Nilsson, K., 1981, Natural killer cells kill tumour cells at a given stage of differentiation, Nature (London) 292:848.

    Article  Google Scholar 

  • Greenberger, J. S., Newberger, P. C., Karpas, A., and Moloney, W. C., 1978, Constitutive and inducible granulocyte—macrophage functions in mouse, rat and human myeloid leukemia-derived culture lines, Cancer Res. 38:3340.

    PubMed  CAS  Google Scholar 

  • Guilbert, J. L., and Stanley, E. R., 1980, Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells, J. Cell Biol. 85:153.

    Article  PubMed  CAS  Google Scholar 

  • Hamilton, J. A., and Moore, M. A. S., 1980, Regulation of the plasminogen activator of macrophage tumor cell lines, Int. J. Immunopharmacol. 2:353.

    Article  PubMed  CAS  Google Scholar 

  • Handman, E., and Burgess, A. W., 1979, Stimulation by granulocyte—macrophage colony-stimulating factor of Leishmania tropica killing by macrophages, J. Immunol. 122:1134.

    PubMed  CAS  Google Scholar 

  • Hoffmann, M. K., Koenig, S., Mittler, R. S., Oettgen, H. F., Ralph, P., Galanos, C., and Hämmerling, U., 1979, Macrophage factor controlling differentiation of B cells, J. Immunol. 122:497.

    PubMed  CAS  Google Scholar 

  • Honma, Y., Kasukabe, T., and Hozumi, M., 1978, Production of differentiation-stimulating factor in cultured mouse myeloid leukemia cells treated with glucocorticoids, Exp. Cell Res. 111:261.

    Article  PubMed  CAS  Google Scholar 

  • Ichikawa, Y., Maeda, M., and Horiuchi, M., 1976, In vitro differentiation of Rauscher virus-induced myeloid leukemia cells, Int. J. Cancer 17:789.

    Article  PubMed  CAS  Google Scholar 

  • Jamieson, G. A., and Vanaman, T. C., 1980, Isolation and characterization of calmodulin from a murine macrophage-like cell line, J. Immunol. 125:1171.

    PubMed  CAS  Google Scholar 

  • Jones, T. C., and Byrne, G. I., 1980, Interactions of macrophages with intravacuolar bacteria and protozoa, in: Mononuclear Phagocytes: Functional Aspects (R. van Furth, ed.), pp. 1611–1629, Nijhoff, The Hague.

    Chapter  Google Scholar 

  • Kaplan, G., and Mørland, B., 1978, Properties of a murine monocytic tumor cell line J-774 in vitro. I. Morphology and endocytosis, Exp. Cell Res. 115:53.

    Article  PubMed  CAS  Google Scholar 

  • Kikutani, H., Kishimoto, T., Sakaguchi, N., Nishizawa, Y., Ralph, P., and Yamamura, Y., 1981, Activation of cyclic AMP-dependent protein kinase activity during LPS stimulation of macrophage tumor cell line, J774.1, Int. J. Immunopharmacol. 3:57.

    Article  PubMed  CAS  Google Scholar 

  • Krizsa, K., and Dexter, T. M., 1978, Cell interactions in long term murine bone marrow culture, Biomed. Express (Paris) 29:162.

    CAS  Google Scholar 

  • Kurland, J. I., Pelus, L., Ralph, P., Bockman, R. S., and Moore, M. A. S., 1979, Synthesis of prostaglandin E by normal and neoplastic macrophages is dependent upon colony-stimulating factors (CSF), Proc. Natl. Acad. Sci. USA 76:2326.

    Article  PubMed  CAS  Google Scholar 

  • Lachman, L. B., and Metzgar, R. S., 1980, Characterization of high and low ML lymphocyteactivating factor (interleukin I) from P388D1 and J774.1 mouse macrophage cell lines, J. Reticuloendothelial Soc. 27:621.

    CAS  Google Scholar 

  • Larrick, J. W., Fischer, D. G., Anderson, S. J., and Koren, H., 1980, Characterization of a human macrophage-like cell line stimulated in vitro: A model of macrophage functions, J. Immunol. 125:6.

    PubMed  CAS  Google Scholar 

  • Levy, J. A., Barrett, S. G., Leong, J. C., and Dirksen, E. R., 1981, Transformation of macrophages from NZB hybrid mice by simian virus 40, J. Reticuloendothelial Soc. 29:35.

    CAS  Google Scholar 

  • Männel, D. N., Moore, R. N., and Mergenhagen, S. E., 1980, Macrophages as a source of tumoricidal activity (TNF), Infect. Immun. 30:523.

    PubMed  Google Scholar 

  • Moore, R. N., Oppenheim, J. J., Farrar, J. J., Carter, C. S., Waheed, A., and Shadduck, R. K., 1980, Production of lymphocyte-activating factor (interleukin 1) by macrophages activated with colony-stimulating factors, J. Immunol. 125:1302.

    PubMed  CAS  Google Scholar 

  • Moore, R. N., Hoffeld, J. T., Farrar, J. J., Mergenhagen, S. E., Oppenheim, J. J., and Shadduck, R. K., 1981, Effects of colony-stimulating factor and other cytokines on macrophage function, Lymphokines 3:168.

    CAS  Google Scholar 

  • Murray, H. W., 1981, Interaction of Leishmania with a macrophage cell line: Correlation between intracellular killing and the generation of oxygen intermediates, J. Exp. Med. 153:1690.

    Article  PubMed  CAS  Google Scholar 

  • Muschel, R. J., Rosen, N., Rosen, O. M., and Bloom, B. R., 1977, Modulation of Fc-mediated phagocytosis by cyclic AMP and insulin in a macrophage-like cell line, J. Immunol. 119:1813.

    PubMed  CAS  Google Scholar 

  • Nagao, K., Yokoro, K., and Aaronson, S. A., 1981, Continuous lines of basophil-mast cells derived from normal mouse bone marrow, Science 212:333.

    Article  PubMed  CAS  Google Scholar 

  • Nagata, K., Takahaski, E., Saito, M., Ono, J., Kuboyama, M., and Ogasa, K., 1976, Simultaneous induction of lysosomal enzymes and phagocytosis in a murine myeloid leukemia cell line, Exp. Cell Res. 100:322.

    Article  PubMed  CAS  Google Scholar 

  • Neumann, C., and Sorg, C., 1981, Independent induction of plasminogen activator and interferon in murine macrophages, J. Reticuloendothelial Soc. 30:79.

    CAS  Google Scholar 

  • Newman, W., Diamond, B., Flomenberg, P., Scharff, M. D., and Bloom, B. R., 1979, Response of a continuous macrophage-like cell line to MIF, J. Immunol. 123:2292.

    PubMed  CAS  Google Scholar 

  • Norin, A. J., 1980, Macrophage cell line mutants deficient in phagocytosis have reduced pinocytic activity, in: Genetic Control of Natural Resistance to Infection and Malignancy (E. Skamene, P. A. L. Kungshavn, and M. Landy, eds.), pp. 531–536, Academic Press, New York.

    Chapter  Google Scholar 

  • Nozawa, R. T., Sekiguchi, R., and Yokota, T., 1980, Stimulation by conditioned medium of L-929 fibroblasts, E. coli lipopolysaccharide, and muramyl dipeptide of candidacidal activity of mouse macrophages, Cell. Immunol. 53:116.

    Article  PubMed  CAS  Google Scholar 

  • Okuma, M., Ichikawa, Y., Yamashito, S., Kitajima, K., and Numa, S., 1976, Studies on some lipogenic enzymes of cultured myeloid leukemic cells, Blood 47:439.

    PubMed  CAS  Google Scholar 

  • Peiris, J. S. M., Gordon, S., Unkeless, J. C., and Porterfield, J. S., 1981, Monoclonal anti-Fc receptor IgG blocks antibody enhancement of viral replication in macrophages, Nature (London) 289:189.

    Article  CAS  Google Scholar 

  • Pellus, L. M., Broxmeyer, H. E., Kurland, J. I., and Moore, M. A. S., 1979, Regulation of macrophage and granulocyte proliferation: Specificities of prostaglandin E and lactoferrin, J. Exp. Med. 150:277.

    Article  Google Scholar 

  • Pfeifer, S., Kallio, A., Vaheri, A., Pettersson, R., and Oker-Blom, N., 1980, Stable bone marrowderived cell line producing transforming avian acute leukemia virus OK 10, Int. J. Cancer 25:235.

    Article  PubMed  CAS  Google Scholar 

  • Pike, M. C., Fisher, D. G., Koren, H. S., and Snyderman, R., 1980, Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines, J. Exp. Med. 152:31.

    Article  PubMed  CAS  Google Scholar 

  • Ralph, P., 1980, Functions of macrophage cell lines, in: Mononuclear Phagocytes—Functional Aspects (R. van Furth, ed.), pp. 439–456, Nijhoff, The Hague.

    Chapter  Google Scholar 

  • Ralph, P., 1981a, Continuous macrophage cell lines—Their use in the study of induced and constitutive macrophage properties and cytotoxicity, Lymphokines 4:175.

    Google Scholar 

  • Ralph, P., 1981b, Continuous cell lines with properties of mononuclear phagocytes, in: Methods for Studying Mononuclear Phagocytes (D. O. Adams, P. Edelson, and H. Koren, eds.), pp. 155–173, Academic Press, New York.

    Chapter  Google Scholar 

  • Ralph, P., 1983, Immunoglobulin class of antibody effective in macrophage ADCC, in: Macrophage-Mediated Antibody-Dependent Cellular Cytotoxicity (H. S. Koren, ed.), Dekker, New York, in press.

    Google Scholar 

  • Ralph, P., and Nakoinz, I., 1977a, Direct toxic effects of immunopotentiators on monocytic, myelomonocytic, and histiocytic tumor cells in culture, Cancer Res. 37:546.

    PubMed  CAS  Google Scholar 

  • Ralph, P., and Nakoinz, I., 1977b, Antibody-dependent killing of erythrocyte and tumor targets by monocyte related cell lines: Enhancement by PPD and LPS, J. Immunol. 119:950.

    PubMed  CAS  Google Scholar 

  • Ralph, P., and Nakoinz, I., 1980, Environmental and chemical dissociation of antibody-dependent phagocytosis from lysis mediated by macrophages: Stimulation of lysis by sulfhydryl-blocking and esterase-inhibiting agents and depression by trypan blue and trypsin, Cell. Immunol. 50:94.

    Article  PubMed  CAS  Google Scholar 

  • Ralph, P., and Nakoinz, I., 1981, Diffierences in antibody-dependent cellular cytotoxicity and activated killing of tumor cells by macrophage cell lines, Cancer Res. 41:3546.

    PubMed  CAS  Google Scholar 

  • Ralph, P., and Nakoinz, I., 1982, Augmentation of macrophage antibody-dependent killing of tumor targets by microtubule inhibitors, Cell. Immunol. 70:321.

    Article  PubMed  CAS  Google Scholar 

  • Ralph, P., and Nakoinz, I., 1983, Monoclonal antibodies of all murine IgG classes, but not IgM, mediate macrophage ADCC to tumor targets, J. Immunol. 131:1028.

    PubMed  CAS  Google Scholar 

  • Ralph, P., Moore, M. A. S., and Nilsson, K., 1976, Lysozyme synthesis by established human and murine histiocytic lymphoma cell lines, J. Exp. Med. 143:1528.

    Article  PubMed  CAS  Google Scholar 

  • Ralph, P., Broxmeyer, H., and Nakoinz, I., 1977, Immunostimulators induce granulocyte/ macrophage colony-stimulating activity and block proliferation in a monocyte tumor cell line, J. Exp. Med. 146:611.

    Article  PubMed  CAS  Google Scholar 

  • Ralph, P., Broxmeyer, H., Nakoinz, I., and Moore, M. A. S., 1978a, Induction of myeloid colonystimulating activity (CSA) in murine monocyte tumor cell lines by macrophage activators, and in a T cell line by Con A, Cancer Res. 38:1414.

    PubMed  CAS  Google Scholar 

  • Ralph, P., Ito, M., Broxmeyer, H. E., and Nakoinz, I., 1978b, Corticosteroids block newly induced but not constitutive functions of macrophage cell lines: CSA production, latex phagocytosis, antibody-dependent lysis of RBC and tumor targets, J. Immunol. 121:300.

    PubMed  CAS  Google Scholar 

  • Ralph, P., Nakoinz, I., Potter, J. E. R., and Moore, M. A. S., 1980a, Activity of macrophage cell lines in tumor cytotoxicity, in: Genetic Control of Natural Resistance to Malignancy and Infection (E. Skamene, P. A. S. Kongshavn, and M. Landy, eds.), pp. 519–530, Academic Press, New York.

    Chapter  Google Scholar 

  • Ralph, P., Nakoinz, I., Diamond, B., and Yelton, D., 1980b, All classes of murine IgG antibody mediate macrophage phagocytosis and lysis of erythrocytes, J. Immunol. 125:1885.

    PubMed  CAS  Google Scholar 

  • Ralph, P., Williams, N., Sheridan, A., Nakoinz, I., Jackson, H., and Moore, M., 1980c, Effector cell functions in long-term culture of murine, prosimian and human bone marrow, in: Mononuclear Phagocytes—Functional Aspects (R. van Furth, ed.), pp. 363–372, Nijhoff, The Hague.

    Chapter  Google Scholar 

  • Ralph, P., Williams, N., Nakoinz, I., Jackson, H., and Watson, J. D., 1982a, Distinct signals for antibody-dependent and nonspecific killing of tumor targets mediated by macrophages, J. Immunol. 129:427.

    PubMed  CAS  Google Scholar 

  • Ralph, P., Nakoinz, I., and Raschke, W. C., 1982b, Induction of differentiated functions coupled with growth inhibition in lymphocyte and macrophage tumor cell lines, in: Maturation Factors in Cancer (M. A. S. Moore, ed.), pp. 245–254, Raven Press, New York.

    Google Scholar 

  • Ralph, P., Williams, N., Moore, M. A. S., and Litcofsky, P. B., 1982c, Induction of antibodydependent and nonspecific tumor killing in human monocytic leukemia cells by nonlymphocyte factors and phorbol ester, Cell. Immunol. 71:215.

    Article  PubMed  CAS  Google Scholar 

  • Ralph, P., Ho, M.-K., Litcofsky, P. B., and Springer, T. A., 1983a, Expression and induction in vitro of macrophage-restricted antigens on murine cell lines, J. Immunol., 130:108.

    PubMed  CAS  Google Scholar 

  • Ralph, P., Nacy, C. A., Meltzer, M. S., Williams, N., and Nakoinz, I., 1983b, Different lymphokine factors activate macrophage cytotoxicity to Leishmania, sarcoma, and antibody-coated lymphoma targets, Cell Immunol. 76:10.

    Article  PubMed  CAS  Google Scholar 

  • Raschke, W. C., Baird, S., Nakoinz, I., and Ralph, P., 1978, Functional macrophage cell lines transformed by Abelson leukemia virus, Cell 15:261.

    Article  PubMed  CAS  Google Scholar 

  • Rosen, N., Piscitello, J., Schneck, J., Muschel, R., Bloom, B. R., and Rosen, O., 1979, Properties of protein kinase and adenylate cyclase-deficient variants of a macrophage-like cell line, J. Cell. Physiol. 98:125.

    Article  PubMed  CAS  Google Scholar 

  • Russell, S. W., Gillespie, G. Y., and Pace, J. L., 1980, Comparison of responses made to activating agents by mouse peritoneal macrophages and cells of the macrophage line RAW264, J. Reticuloendothelial Soc. 27:607.

    CAS  Google Scholar 

  • Sachs, L., 1978, Control of normal cell differentiation and the phenotypic reversion of malignancy in the myeloid leukaemia, Nature (London) 274:535.

    Article  CAS  Google Scholar 

  • Sasada, M., and Johnston, R. B., 1980, Macrophage microbicidal activity: Correlation between phagocytosis-associated oxidative metabolism and the killing of Candida by macrophages, J. Exp. Med. 152:85.

    Article  PubMed  CAS  Google Scholar 

  • Schlesinger, J. J., and Brandriss, M. W., 1981, Growth of 17D yellow fever virus in a macrophage-like cell line, U937: Role of Fc and viral receptors in antibody-mediated infection, J. Immunol. 127:659.

    PubMed  CAS  Google Scholar 

  • Snyderman, R. M., Pike, M. C., Fischer, D. G., and Koren, H. S., 1977, Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1, J. Immunol. 119:2060.

    PubMed  CAS  Google Scholar 

  • Springer, T. A., 1980, Cell-surface differentation in the mouse: Characterization of “jumping” and “lineage” antigens using xenogeneic rat monoclonal antibodies, in: Monoclonal Antibodies. Hybridomas: A New Dimension in Biological Analysis (R. H. Kennett, T. J. McKearn, and K. B. Bechtol, eds.), pp. 185–218, Plenum Press, New York.

    Chapter  Google Scholar 

  • Stadecker, M. J., 1981, Comparison of pyrimidine and purine nucleoside secretion and nucleoside kinase expression in resident and elicited peritoneal macrophages, J. Immunol. 126:1724.

    PubMed  CAS  Google Scholar 

  • Sündstrom, C., and Nilsson, K., 1976, Establishment and characterization of a human histiocytic lymphoma cell line (U-937), Int. J. Cancer 17:565.

    Article  PubMed  Google Scholar 

  • Sündstrom, C., and Nilsson, K., 1977, Cytochemical profile of human hematopoietic biopsy cells and derived cell lines, Br. J. Haematol. 25:601.

    Google Scholar 

  • Taniyama, T., and Holden, H. T., 1980, Cytolytic activity against tumor cells by macrophage cell lines and augmentation by macrophage stimulants, Int. J. Cancer 26:61.

    Article  PubMed  CAS  Google Scholar 

  • Testa, N. G., Dexter, T. M., Scott, D., and Teich, N. M., 1980, Malignant myelomonocytic cells after in vitro infection of marrow cells with Friend leukaemia virus, Br. J. Cancer 41:37.

    Article  Google Scholar 

  • Thoman, M. L., Morgan, E. L., and Weigle, W. O., 1981, Fc fragment activation of T lymphocytes, J. Immunol. 126:632.

    PubMed  CAS  Google Scholar 

  • Tsuchiya, S., Yamabe, M., Yamaguchi, Y., Kobayashi, Y., Konno, T., and Tada, K., 1980, Establishment and characterization of a human acute monocytic leukemia cell line (THP-1), Int. J. Cancer 26:171.

    Article  PubMed  CAS  Google Scholar 

  • Unkeless, J. C., 1979, Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors, J. Exp. Med. 150:580.

    Article  PubMed  CAS  Google Scholar 

  • van Loveren, H., van der Zeijst, B. A. M., De Weger, R. A., van Basten, C., Pijpers, H., and Den Otter, W., 1981, Identification of the neonatal liver cell line NCTC 1469 as a macrophage-like cell line, J. Reticuloendothelial Soc. 29:433.

    Google Scholar 

  • Walker, E. B., Lanier, L. L., and Warner, N. L., 1982, Concomitant induction of the cell surface expression of Ia determinants and accessory cell function by a murine macrophage cell line, J. Exp. Med. 155:629.

    Article  PubMed  CAS  Google Scholar 

  • Walker, W. S., and Gandour, D. M., 1980, Detection and functional assessment of complement receptors on two macrophage-like cell lines, Exp. Cell Res. 129:15.

    Article  PubMed  CAS  Google Scholar 

  • Wardley, R. C., Lawman, M. J., and Hamilton, F., 1980, The establishment of continuous macrophage cell lines from peripheral blood monocytes, Immunology 39:67.

    PubMed  CAS  Google Scholar 

  • Werb, Z., Foley, R., and Munck, A., 1978, Glucocorticoid receptors and glucocorticoid-sensitive secretion of neutral proteinases in a macrophage cell line, J. Immunol. 121:115.

    PubMed  CAS  Google Scholar 

  • Werb, Z., Banda, M. J., and Jones, P. A., 1980, Degradation of connective tissue matrices by macrophages, J. Exp. Med. 152:1340.

    Article  PubMed  CAS  Google Scholar 

  • Williams, N., 1979, Preferential inhibition of murine macrophage colony formation by prostaglandin E, Blood 53:1089.

    PubMed  CAS  Google Scholar 

  • Williams, N., Eger, R. R., Moore, M. A. S., and Mendelsohn, N., 1978, Differentiation of mouse bone marrow precursor cells into neutrophil granulocytes by an activity separation from WEHI-3 cell-conditioned medium, Differentiation 11:59.

    Article  PubMed  CAS  Google Scholar 

  • Williams, N., Jackson, H., Ralph, P., and Nakoinz, I., 1981, Cell interactions influencing murine marrow megakaryocytes: Nature of the potentiator cell in bone marrow, Blood 57:157.

    PubMed  CAS  Google Scholar 

  • Wing, E. J., Koren, H. S., Fischer, D. G., and Kelley, V., 1981, Stimulation of a human macrophagelike cell line (U937) to inhibit multiplication of an intracellular pathogen, J. Reticuloendothelial Soc. 29:321.

    CAS  Google Scholar 

  • Yung, Y.-P., Eger, R., Tertian, G., and Moore, M. A. S., 1981, Purification of a mast cell growth factor and its dissociation from TCGF, J. Immunol. 127:794.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Memorial Sloan—Kettering Cancer Center, Rye, New York, 10580, USA

    Peter Ralph

Authors
  1. Peter Ralph
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Georgetown University School of Medicine, Washington, D.C., USA

    Joseph A. Bellanti

  2. Georgetown University Schools of Medicine and Dentistry, Washington, D.C., USA

    Herbert B. Herscowitz

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ralph, P. (1984). Differentiation and Functional Regulation in Macrophage Cell Lines. In: Bellanti, J.A., Herscowitz, H.B. (eds) Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6784-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6784-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6786-5

  • Online ISBN: 978-1-4757-6784-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation