Skip to main content
SpringerLink
Log in

The Functional Heterogeneity of Macrophages

  • Chapter
Immunology

  • 429 Accesses

Abstract

Macrophages are morphologically and functionally diverse. As a group, they comprise cells that play vital roles in homeostasis (Berlin and Berk, 1975) and in host defense reactions against foreign materials, microbial agents (Nelson, 1969; Nathan et al., 1980), and, possibly, neoplasms (Adams and Snyderman, 1979). These activities, as well as their accessory cell functions in immune responses differ widely from one anatomical site to another and, in many cases, within the same population.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams, D. O., and Snyderman, R., 1979, Do macrophages destroy nascent tumors?, J. Natl. Cancer Inst. 62:1341.

    PubMed  CAS  Google Scholar 

  • Bainton, D. F., 1980, Changes in peroxidase distribution within organelles of blood monocytes and peritoneal macrophages after surface adherence in vitro and in vivo, in: Mononuclear Phagocytes— Functional Aspects, Part I (R. van Furth, ed.), pp. 61–86, Nijhoff, The Hague.

    Chapter  Google Scholar 

  • Balner, H., 1963, Identification of peritoneal macrophages in mouse radiation chimers, Transplantation 1:217.

    Article  PubMed  CAS  Google Scholar 

  • Bar-Eli, M., Territo, M. C., and Cline, M. S., 1980, The progeny of a single progenitor cell can develop characteristics of either a tissue or an alveolar macrophage, Blood 57:95.

    CAS  Google Scholar 

  • Beller, D. I., and Unanue, E. R., 1981, Regulation of macrophage populations: Synthesis and expression of Ia antigen by peritoneal exudate macrophages is a transient event, J. Immunol. 126:263.

    PubMed  CAS  Google Scholar 

  • Berlin, N. I., and Berk, P. D., 1975, The biological life of the red cell, in: The Red Blood Cell (D. MacSurgenor, ed.), pp. 957–1019, Academic Press, New York.

    Google Scholar 

  • Berlin, R. D., Oliver, J. M., and Walter, R. J., 1978, Surface functions in mitosis. I. Phagocytosis, pinocytosis and mobility of surface bound Con A, Cell 15:327.

    Article  PubMed  CAS  Google Scholar 

  • Bianco, C., Griffin, F. M., and Silverstein, S. C., 1975, Studies of the macrophage complement receptor: Alteration of receptor function upon macrophage activation, J. Exp. Med. 141:1278.

    Article  PubMed  CAS  Google Scholar 

  • Brunstetter, M. A., Hardie, J. A., and Schiff, R., 1971, The origin of pulmonary alveolar macrophages, Arch. Intern. Med. 127:1064.

    Article  PubMed  CAS  Google Scholar 

  • Bursuker, I., and Goldman, R., 1979, Derivation of resident and inflammatory macrophages from precursor cells differing in 5′-nucleotidase activity, J. Reticuloendothelial Soc. 26:205.

    CAS  Google Scholar 

  • Campbell, M. W., Sholley, M. M., and Miller, G. A., 1980, Macrophage heterogeneity in tumor resistance: Cytostatic and cytotoxic activity of Corynebacterium parvum-activated and proteose peptone-elicited rat macrophages against Moloney sarcoma tumor cells, Cell. Immunol. 50:153.

    Article  PubMed  CAS  Google Scholar 

  • Carr, I., 1973, The Macrophage, Academic Press, New York.

    Google Scholar 

  • Cohn, Z., 1968, The structure and function of monocytes and macrophages, Adv. Immunol. 9:163.

    Article  PubMed  CAS  Google Scholar 

  • Cole, F. S., Matthews, W. J., Marino, J. T., Gash, D. J., and Colten, H. R., 1980, Control of complement synthesis and secretion in bronchoalveolar and peritoneal macrophages, J. Immunol. 125:1120.

    PubMed  CAS  Google Scholar 

  • Collins, F. M., and Auclair, L. K., 1980, Mononuclear phagocytes in the lungs of unstimulated parabiotic rats, J. Reticuloendothelial Soc. 27:429.

    CAS  Google Scholar 

  • Cowing, C., Schwartz, B. D., and Dickler, H. B., 1978, Macrophage Ia antigens: Macrophage subpopulations differ in their expression of Ia antigens, J. Immunol. 120:378.

    PubMed  CAS  Google Scholar 

  • Crofton, R. W., Diesselhoffden Dulk, M. M. C., and van Furth, R., 1978, The origin, kinetics and characteristics of the Kupffer cells in the normal steady state, J. Exp. Med. 148:1.

    Article  PubMed  CAS  Google Scholar 

  • Daems, W. T., and Brederoo, P., 1973, Electron microscopical studies on the structure, phagocytic properties and peroxidatic activity of resident and exudate peritoneal macrophages, Z. Zellforsch, Mikrosk, Anat. 144:247.

    Article  CAS  Google Scholar 

  • Daems, W. T., and Van der Rhee, H. J., 1980, Peroxidase and catalase in monocytes, macrophages, epithelioid cells and giant cells of the rat, in: Mononuclear Phagocytes—Functional Aspects, Part I (R. van Furth, ed.), pp. 43–60, Nijhoff, The Hague.

    Chapter  Google Scholar 

  • Daems, W. Th., Koerten, H. K., and Soranzo, M. R., 1976, On the differences between monocytederived and tissue macrophages, Adv. Exp. Med. Biol. 73:PT-A2740.

    Google Scholar 

  • Dohlman, J. G., and Goetzl, E. J., 1978, Unique determinants of alveolar macrophage spontaneous and chemokinetically stimulated migration, Cell. Immunol. 39:36.

    Article  PubMed  CAS  Google Scholar 

  • Fishman, M., and Weinberg, D. S., 1979, Functional heterogeneity among peritoneal macrophages: Enzyme content of macrophage subpopulations, Cell. Immunol. 45:437.

    Article  PubMed  CAS  Google Scholar 

  • Gale, R. P., Sparkes, R. S., and Golde, D. W., 1978, Bone marrow origin of hepatic macrophages (Kupffer cells) in humans, Science 201:937.

    Article  PubMed  CAS  Google Scholar 

  • Gandour, D. M., and Walker, W. S., 1981, Cell cycle-dependent expression of the IgG2a isotypespecific Fc-receptor and IgG2a antibody-dependent phagocytosis by the P388D1 macrophage cell line, Proc. 18th Annu. Natl. Meet. Reticuloendothelial Soc., Milwaukee, Abstract 96.

    Google Scholar 

  • Gandour, D. M., and Walker, W. S., 1983, Macrophage cell cycling: Influence on Fc receptors and antibody-dependent phagocytosis, J. Immunol. 130:1108–1112.

    PubMed  CAS  Google Scholar 

  • Garvey, J. S., and Campbell, D. H., 1957, Studies of the retention and properties of 535 labeled antigen in livers of immunized rabbits, J. Immunol. 76:36.

    Google Scholar 

  • Germain, R. N., Pierres, M., and Benacerraf, B., 1980, The role of macrophages in determining the balance of regulatory T-cells specific for L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT), in: Macrophage Regulation of Immunity (E. R. Unanue and A. S. Rosenthal, eds.), pp. 15–33, Academic Press, New York.

    Google Scholar 

  • Godleski, J. J., and Brain, J. D., 1972, The origin of alveolar macrophages in mouse radiation chimers, J. Exp. Med. 136:630.

    Article  PubMed  CAS  Google Scholar 

  • Gorczynski, R. M., 1976, Control of the immune response: Role of macrophages in regulation of antibody- and cell-mediated immune responses, Scand. J. Immunol. 5:1031.

    Article  PubMed  CAS  Google Scholar 

  • Gorczynski, R. M., MacRae, S., and Jennings, J. J., 1979, A novel role for macrophage: Antigen discrimination of distinct carbohydrate bonds, Cell. Immunol. 45:276.

    Article  PubMed  CAS  Google Scholar 

  • Gorenberg, D. J., and Daniele, R. P., 1978, The alveolar macrophages: Its capacity to act as an accessory cell in mitogen-stimulated proliferation of guinea pig lymphocytes, Cell. Immunol. 36:115.

    Article  PubMed  CAS  Google Scholar 

  • Goud, T. J., Shotte, C., and van Furth, R., 1975, Identification and characterization of the monblast in mononuclear phagocyte colonies grown in vitro, J. Exp. Med. 142:1180.

    Article  PubMed  CAS  Google Scholar 

  • Hearst, J. E., Warr, G. A., and Jakab, G. J., 1980, Characterization of murine lung and peritoneal macrophages, J. Reticuloendothelial Soc. 27:443.

    CAS  Google Scholar 

  • Henry, C., Goodman, J. R., Chan, E., Kimura, J., Lucas, A., and Wofsy, L., 1979, Macrophage Ia antigens: Electron microscopic visualization and relevance in an in vitro anti-hapten response, J. Reticuloendothelial Soc. 26:787.

    CAS  Google Scholar 

  • Hogg, N., and Slusarenko, M., 1981, Monoclonal antibodies to subsets of human blood monocytes, in: Heterogeneity of Mononuclear Phagocytes (O. Forster and M. Landy, eds.), pp. 60–65, Academic Press, New York.

    Google Scholar 

  • Holt, P. G., 1979, Studies on the mechanism of inhibition of T-cell proliferation, Immunology 37:437.

    PubMed  CAS  Google Scholar 

  • Holt, P. G., 1980, Interspecies differences in activity in proliferating lymphocyte cultures, Cell. Immunol. 50:210.

    Article  PubMed  CAS  Google Scholar 

  • Holt, P. G., and Batty, J. E., 1980, Comparative studies on the antigen presentation activity of guinea pig and rat alveolar macrophages, Immunology 36:257.

    Google Scholar 

  • Hopper, K. E., Wood, P. R., and Nelson, D. S., 1979, Macrophage heterogeneity, Vox Sang. 36:257.

    Article  PubMed  CAS  Google Scholar 

  • Humphrey, J. H., and Grennan, D., 1981, Different macrophage populations distinguished by means of fluorescent polysaccharides: Recognition and properties of marginal-zone macrophages, Eur. J. Immunol. 121:221.

    Article  Google Scholar 

  • Hunninghake, G. W., and Fauci, A. S., 1976, Immunological reactivity of the lung: A guinea pig model for the study of pulmonary mononuclear cell populations, Cell. Immunol. 26:89.

    Article  PubMed  CAS  Google Scholar 

  • Inchley, C. J., and Howard, J. G., 1969, The immunogenicity of phagocytosed T4 bacteriophage: Cell replacement studies with splenectomized and irradiated mice, Clin. Exp. Immunol. 5:189.

    PubMed  CAS  Google Scholar 

  • Johnson, K. J., Ward, P. A., Striker, G., and Kunkel, R., 1980, A study of the origin of pulmonary macrophages using the Chediak—Higashi marker, Am. J. Pathol. 101:365.

    PubMed  CAS  Google Scholar 

  • Kaplan, G., 1977, Differences in the mode of phagocytosis with Fc and C3 receptors in macrophages, Scand. J. Immunol. 6:797.

    Article  PubMed  CAS  Google Scholar 

  • Kavai, M., Laczko, J., and Csaba, B., 1979, Functional heterogeneity of macrophages, Immunology 36:729.

    PubMed  CAS  Google Scholar 

  • Kavet, R. I., and Brain, J. D., 1977, Phagocytosis: Quantification of rates and intracellular heterogeneity, J. Appl. Physiol. 42:432.

    PubMed  CAS  Google Scholar 

  • Kay, M. M. B., 1981, Isolation of the phagocytosis-inducing IgG-binding antigen on senescent somatic cells, Nature (London) 289:491.

    Article  CAS  Google Scholar 

  • Lee, K.-C., 1980, On the origin and mode of action of functionally distinct macrophage subpopulations, Mol. Cell. Biochem. 30:39.

    Article  PubMed  CAS  Google Scholar 

  • Lee, K.-C., and Berry, D., 1977, Functional heterogeneity in macrophages activated by Corynebacterium parvum: Characterization of subpopulations with different activities in promoting immune responses and suppressing tumor cell growth, J. Immunol. 118:1530.

    PubMed  CAS  Google Scholar 

  • Lee, K.-C., and Wong, M., 1979, Functional heterogeneity of culture-grown bone marrow derived macrophages: Antigen presenting function, J. Immunol. 125:86.

    Google Scholar 

  • Lee, K.-C., Wilkinson, A., and Wong, M., 1979, Antigen-specific murine T-cell proliferation: Role of macrophage surface Ia and factors, Cell. Immunol. 48:79.

    Article  PubMed  CAS  Google Scholar 

  • Lee, K.-C., Wong, M., and McIntyre, D., 1981, Characterization of macrophage subpopulations responsive to activation by endotoxin and by lymphokines, J. Immunol. 126:2474.

    PubMed  CAS  Google Scholar 

  • Lohmann-Matthes, M. L., Domzig, W., and Taskov, H., 1979, Antibody-dependent cellular cytotoxicity against tumor cells: Cultivated bone-marrow-derived macrophage kill tumor cells, Eur. J. Immunol. 9:261.

    Article  PubMed  CAS  Google Scholar 

  • McCarthy, K. F., and MacVittie, T. J., 1978, Velocity sedimentation studies on monocyte-macrophage colony forming cells from marrow, spleen, blood and peritoneal exudate, J. Reticuloendothelial Soc. 24:263.

    CAS  Google Scholar 

  • Melewicz, F. M., and Spiegelberg, H. L., 1980, Fc-receptors for IgE on a subpopulation of human peripheral blood monocytes, J. Immunol. 125:1026.

    PubMed  CAS  Google Scholar 

  • Meltzer, M. S., Nacy, C. A., and Leonard, E. J., 1981, Genetic analysis of macrophage effector function: Development of nonspecific tumoricidal and microbicidal activities during leukocyte activation, in: Heterogeneity of Mononuclear Phagocytes (O. Forster and M. Landy, eds.), pp. 384–389, Academic Press, New York.

    Google Scholar 

  • Miller, G. A., Campbell, M. V., and Hudson, J. L., 1980, Separation of rat peritoneal macrophages into functionally distinct subclasses by centrifugal elutriation, J. Reticuloendothelial Soc. 27:167.

    CAS  Google Scholar 

  • Morahan, P. S., and Miller, G. A., 1981, Heterogeneity of Corynebacterium parvum-elicited macrophages, in: Heterogeneity of Mononuclear Phagocytes (O. Forster and M. Landy, eds.), pp. 161–164, Academic Press, New York.

    Google Scholar 

  • Mosier, D. E., and Coppleson, E., 1968, A three-cell interaction required for the induction of the primary immune response in vitro, Proc. Natl. Acad. Sci. USA 61:542.

    Article  PubMed  CAS  Google Scholar 

  • Mottram, P. L., and Miller, J. F. A. P., 1980, Delayed-type hypersensitivity induced by antigenpulsed, bone marrow-derived macrophages, Eur. J. Immunol. 10:165.

    Article  PubMed  CAS  Google Scholar 

  • Mottram, P. L., Potter, T. A., McKenzie, I. F. C., and Miller, J. F. A. P., 1981, Serological analysis of macrophage surface alloantigens, Cell. Immunol. 59:151.

    Article  PubMed  CAS  Google Scholar 

  • Nacy, C. A., Leonard, E. J., and Meltzer, M. S., 1981, Macrophages in resistance to rickettsial infections: Characterization of lymphokines that induce rickettsiacidal activity in macrophages, J. Immunol. 126:204.

    PubMed  CAS  Google Scholar 

  • Nadler, P. I., Klingenstein, R. J., Richman, L. K., and Ahmann, G. B., 1980, The murine Kupffer cell: Accessory cell function in in vitro primary antibody responses, mitogen-induced proliferation, and stimulation of mixed lymphocytic responses, J. Immunol. 125:2521.

    PubMed  CAS  Google Scholar 

  • Nathan, C. F., Murray, H. W., and Cohn, Z. A., 1980, The macrophage is an effector cell, N. Engl. J. Med. 303:622.

    Article  PubMed  CAS  Google Scholar 

  • Nelson, D. S., 1969, Macrophages and Immunity, North-Holland, Amsterdam.

    Google Scholar 

  • Niederhuber, J. E., 1978, The role of I-region gene products in macrophage—T lymphocyte interaction, Immunol. Rev. 40:28.

    Article  PubMed  CAS  Google Scholar 

  • Norman, S. J., and Weiner, R., 1981, Isolation of two subsets of human peripheral blood monocytes differing in tumor cytotoxicity, in: Heterogeneity of Mononuclear Phagocytes (O. Forster and M. Landy, eds.), pp. 496–500, Academic Press, New York.

    Google Scholar 

  • Norris, D. A., Morris, R. M., Sanderson, R. J., and Kohler, P. F., 1979, Isolation of functional subsets of human peripheral blood monocytes, J. Immunol. 123:166.

    PubMed  CAS  Google Scholar 

  • Oi, V. T., Jones, P. P., Goding, J. W., Herzenberg, L. A., and Herzenberg, L. A., 1978, Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens, Curr. Top. Microbiol. Immunol. 81:115.

    PubMed  CAS  Google Scholar 

  • Oren, R. A., Farnham, A. E., Saito, K., Milofsky, E., and Karnovsky, M. L., 1963, Metabolic patterns in three types of phagocytosing cells, J. Cell Biol. 17:487.

    Article  PubMed  CAS  Google Scholar 

  • Parwaresch, M. R., Radzum, H. J., and Dommes, M., 1981, The homogeneity and monocytic origin of human peritoneal macrophages evidenced by comparison of esterase polymorphism, Am. J. Pathol. 102:209.

    PubMed  CAS  Google Scholar 

  • Pels, E., DeGroot, J. W., Mullink, R., van Unnik, J. A. M., and Den Otter, W., 1980, Identification of two different types of mouse peritoneal exudate cells with ring-shaped nuclei, J. Reticuloendothelial Soc. 27:367.

    CAS  Google Scholar 

  • Pelus, L. M., Broxmeyer, H. E., DeSousa, M., and Moore, M. A. S., 1981, Heterogeneity among resident murine peritoneal macrophages: Separation and functional characterization of monocytoid cells producing granulcoyte—macrophage colony stimulating factor (GM-CSF) and responding to regulation by lactoferrin, J. Immunol. 126:1016.

    PubMed  CAS  Google Scholar 

  • Pennline, K. J., and Herscowitz, H. B., 1981, Dual role for alveolar macrophages in humoral and cellmediated immune responses: Evidence for suppressor and enhancing factors, J. Reticuloendothelial Soc. 30:205.

    CAS  Google Scholar 

  • Pinkett, M. O., Cowdrey, C. R., and Nowell, P. C., 1966, Mixed hematopoietic and pulmonary origin of alveolar macrophages as demonstrated by chromosome markers, Am. J. Pathol. 48:859.

    PubMed  CAS  Google Scholar 

  • Rabellino, E. M., Ross, G. D., and Polley, M. J., 1978, Membrane receptors for mouse leukocytes: Two types of complement receptors for different regions of C3, J. Immunol. 120:879.

    PubMed  CAS  Google Scholar 

  • Raff, H. V., Picker, L. J., and Stobo, J. D., 1980, Macrophage heterogeneity in man: A subpopulation of HLA-Dr-bearing macrophages required for antigen-induced T-cell activation also contains stimulators for autologous-reactive T-cells, J. Exp. Med. 152:581.

    Article  PubMed  CAS  Google Scholar 

  • Reynolds, H. Y., Atkinson, J. P., Newball, H. H., and Frank, M. M., 1975, Receptors for immunoglobulins and complement on human alveolar macrophage, J. Immunol. 114:1813.

    PubMed  CAS  Google Scholar 

  • Rhodes, J., 1975, Macrophage heterogeneity in receptor activity: The activation of macrophage Fcreceptor function in vivo and in vitro, J. Immunol. 114:976.

    PubMed  CAS  Google Scholar 

  • Rice, S., and Fishman, M., 1974, Functional and morphological heterogeneity among rabbit peritoneal macrophages, Cell. Immunol. 11:130.

    Article  PubMed  CAS  Google Scholar 

  • Rogoff, T. M., and Lipsky, P. E., 1980, Antigen presentation by isolated guinea pig Kupffer cells, J. Immunol. 124:1740.

    PubMed  CAS  Google Scholar 

  • Ross, G., 1980, Analysis of different types of leukocyte membrane complement receptors and their interaction with the complement system, J. Immunol. Methods 37:197.

    Article  PubMed  CAS  Google Scholar 

  • Roubin, R., and Zolla-Pazner, S., 1979, Markers of macrophage heterogeneity: Studies of macrophages from various organs of normal mice, Eur. J. Immunol. 9:972.

    Article  PubMed  CAS  Google Scholar 

  • Roubin, R., Kennard, J., Foley, D., and Zolla-Pazner, S., 1981, Markers of macrophage heterogeneity: Altered frequency of macrophage subpopulations after various pathologic stimuli, J. Reticuloendothelial Soc. 29:423.

    CAS  Google Scholar 

  • Rumpold, H., Swetly, P., Boltz, G., and Forster, O., 1981, Monoclonal antibodies against macrophage-associated antigens, in: Heterogeneity of Mononuclear Phagocytes (O. Forster and M. Landy, eds.), pp. 47–51, Academic Press, New York.

    Google Scholar 

  • Ryning, F. W., Krahenbuhl, J. L., and Remington, J. S., 1981, Comparison of cytotoxic and microbicidal function of bronchoalveolar and peritoneal macrophages, Immunology 42:513.

    PubMed  CAS  Google Scholar 

  • Scher, M. G., Beller, D. I., and Unanue, E. R., 1980, Demonstration of a soluble factor that induces exudates rich in Ia-positive macrophage, J. Exp. Med. 152:1684.

    Article  PubMed  CAS  Google Scholar 

  • Schroff, G., Newmann, C., and Sorg, C., 1981, Transglutaminase as a marker for subsets of murine macrophages, Eur. J. Immunol. 11:637.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, R. H., Dickler, H. B., Sachs, D. H., and Schwartz, B. D., 1976, Studies on Ia antigens on immune peritoneal macrophages, Scand. J. Immunol. 5:731.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, R. H., Yano, A., and Paul, W. E., 1978, Interaction between antigen-presenting cells and primed T-lymphocytes, Immunol. Rev. 40:152.

    Article  Google Scholar 

  • Seljelid, R., 1980, Properties of Kupffer cells, in: Mononuclear Phagocytes—Functional Aspects, Part I (R. van Furth, ed.), pp. 157–199, Nijhoff, The Hague.

    Chapter  Google Scholar 

  • Shands, J. W., and Axelrod, B. J., 1977, Mouse peritoneal macrophages: Tritiated thymidine labeling and cell kinetics, J. Reticuloendothelial Soc. 21:69.

    CAS  Google Scholar 

  • Simon, L. M., Robin, E. D., Phillips, J. R., Acevedo, J., Axline, S. G., and Theodore, T., 1977, Enzymatic basis of bioenergetic differences of alveolar versus peritoneal macrophages and enzyme regulation by molecular O2, J. Clin. Invest. 59:443.

    Article  PubMed  CAS  Google Scholar 

  • Stern, A. C., Erb, P., and Gisler, R. H., 1979, Ia-bearing bone-marrow cultured macrophages induce antigen-specific helper T-cells for antibody synthesis, J. Immunol. 123:612.

    PubMed  CAS  Google Scholar 

  • Stewart, C. C., 1980, Formation of colonies by mononuclear phagocytes outside the bone marrow, in: Mononuclear Phagocytes—Functional Aspects, Part I (R. van Furth, ed.), pp. 377–413, Nijhoff, The Hague.

    Chapter  Google Scholar 

  • Takahashi, H., Enzan, H., and Ohkita, T., 1973, Studies on cell kinetics of peritoneal macrophages, Recent Adv. RES Res. 11:85.

    Google Scholar 

  • Thomas, E. D., Ramberg, R. E., Sale, G. E., Sparkes, R. S., and Golde, D. W., 1976, Direct evidence for a bone marrow origin of the alveolar macrophage in man, Science 192:1016.

    Article  PubMed  CAS  Google Scholar 

  • Tice, D. G., Golberg, J., and Nelson, D. A., 1981, Functional properties of isopycnic fractions of human peripheral blood monocytes, J. Reticuloendothelial Soc. 29:459.

    CAS  Google Scholar 

  • Triger, D. R., Alp, M. H., and Wright, R., 1972, Bacterial and dietary antibodies in liver disease, Lancet 1:60.

    Article  PubMed  CAS  Google Scholar 

  • Tzehoval, E., DeBaetselier, P., Feldman, M., and Segal, S., 1981, The peritoneal antigen-presenting macrophage: Control and immunogenic properties of distinct subpopulations, Eur. J. Immunol. 11:323.

    Article  PubMed  CAS  Google Scholar 

  • Unanue, E. R., and Beller, D. I., 1981, Control of Ia expression by macrophages, in: Heterogeneity of Mononuclear Phagocytes (O. Forster and M. Landy, eds.), pp. 214–217, Academic Press, New York.

    Google Scholar 

  • van der Meer, J. W. M., Beelen, R. H. J., Fluitsma, D. M., and van Furth, R., 1979, Ultrastructure of mononuclear phagocytes developing in liquid bone marrow cultures: A study on peroxidatic activity, J. Exp. Med. 149:17.

    Article  PubMed  Google Scholar 

  • van Furth, R. (ed.), 1970, The origin and turnover of promonocytes, monocytes and macrophages in normal mice, in: Mononuclear Phagocytes, pp. 151–165, Blackwell, Oxford.

    Google Scholar 

  • van Furth, R. (ed.), 1980, Cells of the mononuclear phagocyte system—Nomenclature in terms of sites and conditions, in: Mononuclear Phagocytes—Functional Aspects, pp. 1–30, Nijhoff, The Hague.

    Google Scholar 

  • van Furth, R., Diesselhoffden Dulk, M. M. C., Raeburn, J. A., van Zwet, T. L., Crofton, R., and van Oudalblas, A. B., 1980, Characteristics, origin and kinetics of human and murine mononuclear phagocytes, in: Mononuclear Phagocytes—Functional Aspects, Part I (R. van Furth, ed.), pp. 279–298, Nijhoff, The Hague.

    Chapter  Google Scholar 

  • van Oudalblas, A. B., van der Linden-Schrever, B., and van Furth, R., 1981, Origin and kinetics of pulmonary macrophages during an inflammatory reaction induced by intravenous administration of heat-killed bacillus Calmette-Guerin, J. Exp. Med. 154:235.

    Article  Google Scholar 

  • Virolainen, M., 1968, Hematopoietic origin of macrophages as studied by chromosome markers in mice, J. Exp. Med. 127:943.

    Article  PubMed  CAS  Google Scholar 

  • Volkman, A., 1976a, Disparity in origin of mononuclear phagocyte populations, J. Reticuloendothelial Soc. 19:249.

    CAS  Google Scholar 

  • Volkman, A., 1976b, Monocyte kinetics and their changes in infection, in: Immunobiology of the Macrophage (D. S. Nelson, ed.), pp. 291–322, Academic Press, New York.

    Google Scholar 

  • Volkman, A., Chang, N. C., Strausbauch, P. H., and Morahan, P. S., 1981, Differential effects of chronic monocyte depletion on macrophage populations laboratory investigation 49:291–298.

    Google Scholar 

  • Walker, W. S., 1971, Macrophage functional heterogeneity in the in vitro-induced immune response, Nature New Biol. 229:211.

    PubMed  CAS  Google Scholar 

  • Walker, W. S., 1974, Functional heterogeneity of macrophages: Subclasses of peritoneal macrophages with different antigen binding activities and immune complex receptors, Immunology 26:1025.

    PubMed  CAS  Google Scholar 

  • Walker, W. S., 1976a, Macrophage functional heterogeneity, in: Immunobiology of the Macrophage (D. S. Nelson, ed.), pp. 91–110, Academic Press, New York.

    Google Scholar 

  • Walker, W. S., 1976b, Macrophage functional heterogeneity in the induction and expression of acquired immunity, J. Reticuloendothelial Soc. 20:57.

    CAS  Google Scholar 

  • Walker, W. S., and Yen, S.-E., 1982, Complement receptor phenotypes of culture-derived murine macrophages, J. Cell. Physiol. 110:227–284.

    Article  Google Scholar 

  • Walker, W. S., Hester, R. B., Gandour, D. M., and Stewart, C. C., 1981, Evidence of a distinct progenitor for the Ia-bearing murine bone-marrow-derived mononuclear phagocyte, in: Heterogeneity of Mononuclear Phagocytes (O. Forster and M. Landy, eds.), pp. 229–232, Academic Press, New York.

    Google Scholar 

  • Weinberg, D. S., and Unanue, E. R., 1981, Antigen-presenting function of alveolar macrophages: Uptake and presentation of Listeria monocytogenes, J. Immunol. 126:794.

    CAS  Google Scholar 

  • Weinberg, D. S., Fishman, M., and Veit, B. C., 1978, Functional heterogeneity among peritoneal macrophages: Effector cell activity of macrophages against syngenic and xenogeneic tumor cells, Cell. Immunol. 38:94.

    Article  PubMed  CAS  Google Scholar 

  • Werdelin, O., Braendstrup, O., and Pederson, E., 1974, Macrophage—lymphocyte clusters in the immune response to soluble protein antigen in vitro. I. Roles of lymphocytes and macrophages in cluster formation, J. Exp. Med. 140:1245.

    Article  PubMed  CAS  Google Scholar 

  • Whitcomb, M. E., 1978, Identification of a receptor for complement on the guinea pig alveolar macrophage membrane, Am. Rev. Respir. Dis. 118:431.

    PubMed  CAS  Google Scholar 

  • White, R., Lin, H.-S., and Kun, C., 1977, Elastase secretion by peritoneal exudative and alveolar macrophages, J. Exp. Med. 146:802.

    Article  PubMed  CAS  Google Scholar 

  • Widmann, J. J., and Fahimi, H. D., 1975, Proliferation of mononuclear phagocytes (Kupffer cells) and endothelial cells in regenerating liver, Am. J. Pathol. 80:349.

    PubMed  CAS  Google Scholar 

  • Widmann, J. J., Cotran, R. S., and Fahimi, H. D., 1972, Mononuclear phagocytes (Kupffer cells) and endothelial cells: Identification of two functional cell types in rat liver sinusoids by endogenous peroxidase activity, J. Cell Biol. 52:159.

    Article  PubMed  CAS  Google Scholar 

  • Wing, E. J., Gardner, I. D., Ryning, F. W., and Remington, J. S., 1977, Dissociation of effector junctions in populations of activated macrophages, Nature (London) 268:642.

    Article  CAS  Google Scholar 

  • Yamashita, V., and Shevach, E. M., 1977, The expression of Ia antigen on immunocompetent cells in the guinea pig: Ia antigens on macrophages, J. Immunol. 119:1584.

    PubMed  CAS  Google Scholar 

  • Yasaka, T., Mantich, N. M., Boxer, L. A., and Baehner, R. L., 1981, Functions of human monocyte and lymphocyte subsets obtained by countercurrent centrifugal elutriation: Differing functional capacities of human monocyte subsets, J. Immunol. 127:1515.

    PubMed  CAS  Google Scholar 

  • Zembala, M., and Asherson, G. L., 1970, The rapid purification of peritoneal exudate macrophages by Ficoll (polysucrose) density gradient centrifugation, Immunology 19:677.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, 38101, USA

    William S. Walker & Raymond B. Hester

Authors
  1. William S. Walker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Raymond B. Hester
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Georgetown University School of Medicine, Washington, D.C., USA

    Joseph A. Bellanti

  2. Georgetown University Schools of Medicine and Dentistry, Washington, D.C., USA

    Herbert B. Herscowitz

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer Science+Business Media New York

About this chapter

Cite this chapter

Walker, W.S., Hester, R.B. (1984). The Functional Heterogeneity of Macrophages. In: Bellanti, J.A., Herscowitz, H.B. (eds) Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6784-1_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6784-1_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6786-5

  • Online ISBN: 978-1-4757-6784-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation