Immunology pp 319-337 | Cite as

Role of Macrophages in Immunopotentiation by Adjuvants

  • Richard M. Schultz
  • Jon R. Schmidtke
  • Arthur G. Johnson


There is considerable evidence that macrophages can modulate the immune response in vivo (for reviews, see Unanue, 1972, 1980; Oppenheim and Seeger, 1976; Oehler et al., 1978). Aside from their role as tumoricidal and microbicidal effector cells, evidence from in vitro studies indicates that macrophages are required for antigen- or mitogen-induced lymphocyte proliferation, antibody production, and the production of some lymphokines (Oppenheim and Rosenstreich, 1976) . These responses are critically dependent on presenting antigen in association with macrophage surface membrane components of the major histocompatibility complex such as Ia and on growth and differentiation factors supplied by macrophages.


Migration Inhibitory Factor Macrophage Activation Mouse Peritoneal Macrophage Peritoneal Exudate Cell Muramyl Dipeptide 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Richard M. Schultz
    • 1
  • Jon R. Schmidtke
    • 1
  • Arthur G. Johnson
    • 2
  1. 1.Department of Immunology ResearchLilly Research LaboratoriesIndianapolisUSA
  2. 2.Department of Microbiology and ImmunologyThe University of MinnesotaDuluthUSA

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