Abstract
Since their discovery in the 1930s as potent autacoids, and their subsequent isolation and characterization in the 1960s as derivatives of arachidonic acid, prostaglandins have been the topic of many symposia and the basis for exhaustive research. These ubiquitous fatty acid derivatives have proven to be extremely powerful chemicals synthesized by nearly every cell in the human body, except the erythrocyte. Their synthesis and release have shown to be dependent upon a wide variety of cell membrane perturbations ranging from slight mechanical or chemical disturbances to the binding of compounds to specific receptors. Increasing evidence supports the theory that prostaglandins of all types are “made on demand” and not stored, since the amount of prostaglandins released from specific cells, in response to an appropriate stimulus, is greater than the total prostaglandin content of the cells prior to stimulation (Horton, 1979).
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References
Babior, B. M., 1978, Oxygen-dependent microbial killing by phagocytes, N. Engl. J. Med. 298:659.
Bockman, R. S., 1981, Prostaglandin production by human blood monocytes and mouse peritoneal macrophages: Synthesis dependent on in vitro culture conditions, Prostaglandins 21:9.
Bonney, R. J., Wightman, P. D., Davies, P., Kuehl, F. A., and Humes, J. L., 1978, Regulation of prostaglandin synthesis and of selective release of lysosomal hydrolases by mouse peritoneal macrophage, Biochem. J. 176:433.
Bonney, R. J., Naruns, P., Davies, P., and Humes, J. L., 1979, Antigen—antibody complexes stimulate the synthesis and release of prostaglandins by mouse peritoneal macrophages, Prostaglandins 18:605.
Bonta, I. L., and Parnham, M. J., 1978a, Prostaglandins and chronic inflammation, Biochem. Pharmacol. 27:1611.
Bonta, I. L., and Parnham, M. J., 1978b, Time-dependent pro and anti-inflammatory effects of prostaglandin (PG) E1 on experimental granulomata in rats, Br. J. Pharmacol. 62: 417.
Bonta, I. L., and Parnham, M. J., 1979, Cannulated sponge implants in rats for the study of timedependent pharmacological influences on inflammatory granulomatous. J. Pharmacol. Methods 2:1.
Bonta, I. L., Parnham, M. J., and Adolfs, M. J. P., 1977, Reduced exudation and increased tissue proliferation during chronic inflammation in rats deprived of endogenous prostaglandin precursors, Prostaglandins 14:295.
Boros, D. L., 1978, Granulomatous inflammations, Prog. Allergy 24:183.
Brogt, P. C., and Bonta, I. L., 1979, In vivo metabolism of [1-14C]arachidonic acid during different phases of granuloma development in the rat, Biochem. Pharmacol. 28:1581.
Davies, P., and Allison, A. C., 1976, The macrophage as a secretory cell in chronic inflammation, Agents Actions 6:60.
Davies, P., Bonney, R. J., Humes, J. L., and Kuehl, F. A. 1980, The synthesis of arachidonic acid oxygenation products by various mononuclear phagocyte populations, in: Mononuclear Phagocytes (R. van Furth, ed.), pp. 1317–1350, Nijhoff, The Hague.
Farzod, A., Penneys, N. S., Ghaffar, A., Zibah, V. A., and Schlassberg, J., 1977, PGE2 and PGF2α biosynthesis in stimulated and nonstimulated peritoneal preparations containing macrophages, Prostaglandins 14:829.
Goldyne, M. E., 1977, Prostaglandins and the modulation of immunological responses, Int. J. Dermatol. 16:701.
Goodwin, J. S., and Webb, D. R., 1980, Regulation of the immune response by prostaglandins, Clin. Immunol. Immunopathol. 15:106.
Goodwin, J. S., Bankhurst, A. D., and Messner, R. P., 1977, Suppression of human T-cell mitogenesis by prostaglandin: Existence of a prostaglandin-producing suppressor cell, J. Exp. Med. 146:1719.
Hansen, H. S., 1976, 15-Hydroxyprostaglandin dehydrogenase: A review, Prostaglandins 12:647.
Henney, C. S., Bourne, H. R., and Lichtenstein, L. M., 1971, The role of cyclic AMP in the specific cytolytic activity of lymphocytes, J. Immunol. 108:1526.
Higgs, G. A., Higgs, E. A., and Solman, J. A., 1979, Prostacyclin and inflammation, in: Prostacyclin (J. R. Vane and S. Bergstrom, eds.), pp. 187–193, Raven Press, New York.
Horton, E. W., 1979, Prostanoids in health and disease, in: Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids (S. M. Roberts and F. Scheinmann, eds.), pp. 1–16, Pergamon Press, Elmsford, N.Y.
Humes, J. L., Bonney, R. J., Pelus, L., Dahlgron, M. E., Kuehl, F. A., and Davies, P., 1977, Macrophages synthesize and release prostaglandins in response to inflammatory stimuli, Nature (London) 269:149.
Humes, J. L., Davies, P., Bonney, R. J., and Kuehl, F. A., 1978, Phorbol myristate acetate (PMA) stimulates the release of arachidonic acid and its cyclooxygenation products by macrophages, Fed. Proc. 37:1318.
Johnson, K. J., Fantone, J. C., Kaplan, J., and Ward, P. A., 1981, In vivo damage of rat lungs by oxygen metabolites, J. Clin. Invest. 67:983.
Klebanoff, S. J., and Hansen, C. B., 1975, Antimicrobial systems of mononuclear phagocytes, in: Mononuclear Phagocytes in Immunity, Infection and Pathology (R. van Furth, ed.), pp. 507–517, Blackwell, Oxford.
Kunkel, S. L., Thrall, R. S., Kunkel, R. G., Ward, P. A., and Zurier, R. B., 1979, Suppression of immune complex vasculitis in rats by prostaglandins, J. Clin. Invest. 64:1525.
Kunkel, S. L., Fantone, J. C., Ward, P. A., and Zurier, R. B., 1981a, Modulation of inflammatory reactions by prostaglandins, Prog. Lipid Res. 20:249.
Kunkel, S. L., Ogawa, H., Conran, P., Ward, P. W., and Zurier, R. B., 1981b, Suppression of acute and chronic inflammation by orally administered prostaglandins, Arthritis Rheum. 24:1151.
Kurtland, J. I., Broxmeyer, H. E., Pelus, L. M., Bickman, R. S., Moore, M. A. S., 1978, Role for monocyte-macrophage-derived colony-stimulating factor and prostaglandin E in the positive and negative feedback control of myeloid stem cell proliferation, Blood 52:388.
Lehmeyer, J. E., and Johnson, R. B., 1978, Effects of anti-inflammatory drugs and agents that elevate intracellular cyclic AMP on the release of toxic oxygen metabolites by phagocytes: Studies in a model of tissue-bound IgG, Clin. Immunol. Immunopathol. 9:482.
Lichtenstein, L. M., and DiBernardo, R., 1971, The immediate allergic response: In vitro action of cyclic AMP and other drugs on the two stages of histamine release, J. Immunol. 107:1131.
Oort, J., and Scheper, R. J., 1977, Histopathology of acute and chronic inflammation, Agents Actions Suppl. 3:25.
Oropeza-Rendon, R. L., Speth, V., Hiller, G., Weber, K., and Fischer, H., 1979, Prostaglandin E1 reversibly induces morphological changes in macrophages and inhibits phagocytosis, Exp. Cell Res. 119:365.
Parker, C. W., 1972, The role of prostaglandins in the immune response, in: Prostaglandins in Cellular Biology (P. W. Ramwell and B. B. Pharriss, eds.), pp. 173–190, Academic Press, New York.
Pelus, L. M., and Strausser, H. R., 1977, Prostaglandins and the immune response, Life Sci. 20:903.
Ramwell, P., 1980, General introduction to clinical implications of prostaglandin synthetase inhibition, in: Prostaglandin Synthetase Inhibitors: New Clinical Applications (P. Ramwell, ed.), p. 5, Liss, New York.
Rivikin, I., Rosenblatt, J., and Becker, E. L., 1975, The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils, J. Immunol. 115:1126.
Smith, R. L., and Weidemann, M. J., 1980, Reactive oxygen production associated with arachidonic acid metabolism by peritoneal macrophages, Biochem. Biophys. Res. Commun. 97:973.
Trang, L. E., 1977, Levels of prostaglandin F2 alpha and E1 and thromboxane B1 in joint fluid in rheumatoid arthritis, Scand. J. Rheum. 6:151.
Tsurufuji, S., Sato, H., Min, K. R., and Ohuchi, K., 1978, Difference in the anti-inflammatory effects of indomethacin between acute and chronic stages of carrageenin-induced inflammation, J. Pharm. Dyn. 1:8.
Vane, J. R., 1976, Prostaglandin as mediators of inflammation in: Advances in Prostaglandin and thromboxane Research (B. Samuelson and R. Paoletti, ed.), Raven Press, New York, pp. 791–798.
Warren, K. S., Mahmoud, A. A. F., Boros, D. L., Rall, T. W., and Carpenter, C. C. J., 1974, In vivo suppression by cholera toxin of cell-mediated and foreign body inflammatory response. J. Immunol. 112:996.
Weidemann, M. J., Peskar, B. A., Wrongemann, K., Reitschel, E. T., and Fischer, H., 1978, Prostaglandin and thromboxane synthesis in a pure macrophage population and the inhibition, by E-type prostaglandins, of chemiluminescence, FEBS Lett. 89:136.
Zurier, R. B., Weissman, G., Hoffstein, S., Kammermann, S., and Tiu, M. H., 1974, Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists and agents which affect microtubule function, J. Clin. Invest. 53:297.
Zurier, R. B., Damjarrow, I., Miller, P. L., and Biewer, B. F., 1978, Prostaglandin E treatment prevents progression of nephritis in murine lupus erythematosus, J. Clin. Lab. Immunol. 1:95.
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Kunkel, S.L., Chensue, S.W., Fantone, J.C., Ward, P.A. (1984). Role of Prostaglandins in Macrophage Cell Function. In: Bellanti, J.A., Herscowitz, H.B. (eds) Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6784-1_14
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DOI: https://doi.org/10.1007/978-1-4757-6784-1_14
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