Since their discovery in the 1930s as potent autacoids, and their subsequent isolation and characterization in the 1960s as derivatives of arachidonic acid, prostaglandins have been the topic of many symposia and the basis for exhaustive research. These ubiquitous fatty acid derivatives have proven to be extremely powerful chemicals synthesized by nearly every cell in the human body, except the erythrocyte. Their synthesis and release have shown to be dependent upon a wide variety of cell membrane perturbations ranging from slight mechanical or chemical disturbances to the binding of compounds to specific receptors. Increasing evidence supports the theory that prostaglandins of all types are “made on demand” and not stored, since the amount of prostaglandins released from specific cells, in response to an appropriate stimulus, is greater than the total prostaglandin content of the cells prior to stimulation (Horton, 1979).
KeywordsPhorbol Myristate Acetate Mononuclear Phagocyte Phorbol Myristate Acetate Mouse Peritoneal Macrophage Granulomatous Response
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- Bonta, I. L., and Parnham, M. J., 1978b, Time-dependent pro and anti-inflammatory effects of prostaglandin (PG) E1 on experimental granulomata in rats, Br. J. Pharmacol. 62: 417.Google Scholar
- Farzod, A., Penneys, N. S., Ghaffar, A., Zibah, V. A., and Schlassberg, J., 1977, PGE2 and PGF2α biosynthesis in stimulated and nonstimulated peritoneal preparations containing macrophages, Prostaglandins 14:829.Google Scholar
- Henney, C. S., Bourne, H. R., and Lichtenstein, L. M., 1971, The role of cyclic AMP in the specific cytolytic activity of lymphocytes, J. Immunol. 108:1526.Google Scholar
- Higgs, G. A., Higgs, E. A., and Solman, J. A., 1979, Prostacyclin and inflammation, in: Prostacyclin (J. R. Vane and S. Bergstrom, eds.), pp. 187–193, Raven Press, New York.Google Scholar
- Horton, E. W., 1979, Prostanoids in health and disease, in: Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids (S. M. Roberts and F. Scheinmann, eds.), pp. 1–16, Pergamon Press, Elmsford, N.Y.Google Scholar
- Humes, J. L., Davies, P., Bonney, R. J., and Kuehl, F. A., 1978, Phorbol myristate acetate (PMA) stimulates the release of arachidonic acid and its cyclooxygenation products by macrophages, Fed. Proc. 37:1318.Google Scholar
- Klebanoff, S. J., and Hansen, C. B., 1975, Antimicrobial systems of mononuclear phagocytes, in: Mononuclear Phagocytes in Immunity, Infection and Pathology (R. van Furth, ed.), pp. 507–517, Blackwell, Oxford.Google Scholar
- Kunkel, S. L., Fantone, J. C., Ward, P. A., and Zurier, R. B., 1981a, Modulation of inflammatory reactions by prostaglandins, Prog. Lipid Res. 20:249.Google Scholar
- Kurtland, J. I., Broxmeyer, H. E., Pelus, L. M., Bickman, R. S., Moore, M. A. S., 1978, Role for monocyte-macrophage-derived colony-stimulating factor and prostaglandin E in the positive and negative feedback control of myeloid stem cell proliferation, Blood 52:388.Google Scholar
- Ramwell, P., 1980, General introduction to clinical implications of prostaglandin synthetase inhibition, in: Prostaglandin Synthetase Inhibitors: New Clinical Applications (P. Ramwell, ed.), p. 5, Liss, New York.Google Scholar
- Rivikin, I., Rosenblatt, J., and Becker, E. L., 1975, The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils, J. Immunol. 115:1126.Google Scholar
- Vane, J. R., 1976, Prostaglandin as mediators of inflammation in: Advances in Prostaglandin and thromboxane Research (B. Samuelson and R. Paoletti, ed.), Raven Press, New York, pp. 791–798.Google Scholar
- Zurier, R. B., Damjarrow, I., Miller, P. L., and Biewer, B. F., 1978, Prostaglandin E treatment prevents progression of nephritis in murine lupus erythematosus, J. Clin. Lab. Immunol. 1:95.Google Scholar