Immunology pp 265-288 | Cite as

Lymphocyte Mediators That Modulate the Behavior of Macrophages

  • Ross Rocklin


T lymphocytes mediate a number of cellular-immune reactions including cutaneous delayed hypersensitivity of the tuberculin or contact types, resistance to infection by intracellular facultative microorganisms, host versus graft and graft versus host rejection phenomena, and tumor surveillance. These reactions result from complex cellular interactions between subpopulations of T lymphocytes and T lymphocytes and macrophages. The T cell may function directly as an effector cell or indirectly by orchestrating interactions between lymphocytes and macrophages. As a result of these activation signals, the macrophage may then develop into a more efficient phagocytic “killer cell” or in turn transmit signals that modulate T-cell functions in either a positive or a negative way.


Migration Inhibitory Factor Human Monocyte Complement Receptor Macrophage Migration Inhibitory Factor Tumoricidal Activity 
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© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Ross Rocklin
    • 1
  1. 1.Allergy Division, Department of Medicine, New England Medical CenterTufts University School of MedicineBostonUSA

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