Immunology pp 201-264 | Cite as

Antigen-Nonspecific Factors Elaborated by Macrophages Which Stimulate Lymphocytes

  • David D. Wood


The essential role of macrophages in supporting lymphocyte responses in culture has been well established since the initial demonstration that neither antibody production nor T-cell proliferation takes place in the absence of macrophages (Mosier, 1967; Oppenheim et al., 1968). At least three functions of the macrophage have been described which contribute to the vigor of the immune response. The most easily demonstrated of these is a feeder layer effect which can be replaced almost entirely by the addition of 2-mercaptoethanol to the culture (Chen and Hirsch, 1972). It has been suggested that the mercaptoethanol replaces the macrophage by modifying some high-molecular-weight component present in fetal calf serum (Opitz et al., 1977) or by keeping glutathione reduced (Hoffeld and Oppenheim, 1980).


Muramyl Dipeptide Murine Peritoneal Macrophage Endogenous Pyrogen Murine Thymocyte Helper Factor 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • David D. Wood
    • 1
  1. 1.Department of ImmunologyAyerst Research LaboratoriesPrincetonUSA

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