Abstract
The essential role of macrophages in supporting lymphocyte responses in culture has been well established since the initial demonstration that neither antibody production nor T-cell proliferation takes place in the absence of macrophages (Mosier, 1967; Oppenheim et al., 1968). At least three functions of the macrophage have been described which contribute to the vigor of the immune response. The most easily demonstrated of these is a feeder layer effect which can be replaced almost entirely by the addition of 2-mercaptoethanol to the culture (Chen and Hirsch, 1972). It has been suggested that the mercaptoethanol replaces the macrophage by modifying some high-molecular-weight component present in fetal calf serum (Opitz et al., 1977) or by keeping glutathione reduced (Hoffeld and Oppenheim, 1980).
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Wood, D.D. (1984). Antigen-Nonspecific Factors Elaborated by Macrophages Which Stimulate Lymphocytes. In: Bellanti, J.A., Herscowitz, H.B. (eds) Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6784-1_12
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