The Heart in Diabetes: Results of Trials

  • Giulio Zuanetti
  • Roberto Latini
  • Aldo P. Maggioni


It has been known for many years that diabetes has profound consequences on the cardiovascular system leading to increased morbidity and mortality in diabetic patients [1]. In the last years, the completion of several large trials allowed to gather critical information on the efficacy and safety of different drugs in patients with a variety of cardiovascular diseases. In most of these trials diabetic patients, generally identified on the basis of clinical history and with no distinction between type 1 and type 2 diabetes, represented an important proportion of the randomized population, ranging between 10 and 25 % in most cases. In this brief review, we will summarize how these trials helped in widening our knowledge of the pathophysiology, prognosis and pharmacological treatment of diabetic patients with cardiovascular disease. Table 6–1 shows the meaning of the acronyms of the trials quoted in this review, where three specific settings will be discussed: acute myocardial infarction (MI); congestive heart failure (CHF) and treatment of myocardial ischemia with coronary angioplasty (PTCA).


Diabetic Patient Acute Myocardial Infarction Congestive Heart Failure Patient Scandinavian Simvastatin Survival Study Concomitant Risk Factor 
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Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • Giulio Zuanetti
    • 1
  • Roberto Latini
    • 1
  • Aldo P. Maggioni
    • 2
  1. 1.Istituto Mario NegriMilanoItaly
  2. 2.Centro Studi ANMCOFirenzeItaly

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