Early Renal Hyperfunction and Hypertrophy in IDDM Patients Including Comments on Early Intervention

  • Margrethe Mau Pedersen


Diabetic nephropathy is the main cause of reduced survival in insulin-dependent diabetes. Much interest is paid to early alterations in kidney function and structure, since a relationship may exist between such early abnormalities and later development of diabetic nephropathy. A modest increase in urinary albumin excretion, microalbuminuria, has been identified as an early marker of diabetic nephropathy, and therapeutical intervention postponing the onset of overt nephropathy has been introduced. In this chapter the initial renal changes in IDDM, glomerular hyperfunction and renal hypertrophy, will be addressed.


Glomerular Filtration Rate Diabetic Nephropathy Atrial Natriuretic Peptide Aldose Reductase Renal Plasma Flow 
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Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • Margrethe Mau Pedersen
    • 1
  1. 1.Medical Department MAarhus KommunehospitalAarhusDenmark

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