Renal Ultrastructural Changes in Microalbuminuric IDDM-Patients

  • Hans-Jacob Bangstad
  • Susanne Rudberg
  • Ruth Østerby


Associations between early stages of diabetic nephropathy and structural changes is far from clarified. Some reports present rather marked changes in patients in the preclinical stage whereas others found very moderate changes in the early stage of nephropathy. Hence the issue is still a challenge to further studies. This chapter concentrates on the renal morphological changes in patients with insulin dependent diabetes mellitus (IDDM) and early nephropathy and the influence of blood glucose control on these structural changes. Associations between early stages of diabetic nephropathy and structural changes is far from clarified. Some reports present rather marked changes in patients in the preclinical stage whereas others found very moderate changes in the early stage of nephropathy. Hence the issue is still a challenge to further studies. This chapter concentrates on the renal morphological changes in patients with insulin dependent diabetes mellitus (IDDM) and early nephropathy and the influence of blood glucose control on these structural changes.


Diabetic Nephropathy Mesangial Cell Blood Glucose Control Continuous Subcutaneous Insulin Infusion Mesangial Matrix 
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Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • Hans-Jacob Bangstad
    • 1
    • 2
    • 3
  • Susanne Rudberg
    • 1
    • 2
    • 3
  • Ruth Østerby
    • 1
    • 2
    • 3
  1. 1.Department of Pediatrics, Aker Diabetes Research CentreAker University HospitalOsloNorway
  2. 2.Department of Woman and Child Health, Pediatric UnitKarolinska InstituteStockholmSweden
  3. 3.Laboratory for Electron MicroscopyAarhus KommunehospitalAarhusDenmark

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