Effects of Insulin on the Kidney and the Cardiovascular system

  • Ele Ferrannini


The concept that exogenous insulin administration may be associated with haemodynamic changes has appeared in the literature soon after the purified hormone became available for use in humans (e.g. [1]). Subsequently, however, these changes have mostly been ascribed to the counter-regulatory hormone response to the attendant hypoglycaemia. It has not been until the introduction of the glucose clamp technique, by which hyperinsulinaemia can be uncoupled from hypoglycaemia, that the existence of specific vascular actions of the hormone has been recognised. Interest has initially focussed on insulin-induced vasodilatation [2]; more recently, a wider range of haemodynamic effects of insulin has been characterised, and their possible physiological significance is beginning to be appreciated


Insulin Resistance Limb Blood Flow Insulin Exposure Chloride Reabsorption Exogenous Insulin Administration 
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Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • Ele Ferrannini
    • 1
  1. 1.Department of Internal Medicine and Metabolism UnitCNR Institute of Clinical Physiology at the University of PisaItaly

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