Familial Factors in Diabetic Nephropathy

  • David J. Pettitt
  • William C. Knowler
  • Robert G. Nelson


Reports of nephropathy developing in some patients with apparently well controlled diabetes and not developing in some patients even after years of severe hyperglycemia lead to the conclusion, expressed by several researchers [1–5], that some, but not all, individuals are predisposed to the development of diabetic renal disease. This chapter reviews some of the data that indicate that there are familial differences in the predisposition to diabetic renal disease. If this familial predisposition is genetic, there must be an interaction between the genes and the environment, and it is often impossible to differentiate between genetic inheritance and the effect of a common environment shared by family members.


Renal Disease Diabetic Nephropathy Diabetic Kidney Disease Familial Factor Diabetic Renal Disease 
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Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • David J. Pettitt
    • 1
  • William C. Knowler
    • 1
  • Robert G. Nelson
    • 1
  1. 1.Phoenix Epidemiology and Clinical Research Branch, NIDDKPhoenixUSA

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