Microalbuminuria and Diabetic Pregnancy
Renal and vascular damage, including blood pressure elevation, is often involved in complications of diabetic pregnancy. Therefore, sensitive methods for measuring elevatedurinary protein excretion, especially of albumin (so-calledmicroalbuminuria) [1–3], might be useful in early prediction of complications in diabetic as well as nondiabetic pregnancy. This is the case in nonpregnant diabetics [3–9], in whom microalbuminuria is a sensitive marker of generalizedsubclinical vascular disturbance and damage  and in whom it predicts overt nephropathy [3–6] as well as proliferative retinopathy . In a normal pregnancy, increases in UAER are either absent or very limited [10–12]. However, certain low-molecular weight plasma protiens may increase in excretion rate . There are certainly increases in albumin uria when preeclampsia is present [14,23]. This chapter deals with the pattern of urinary albumin excretion rate in diabetic pregnancy as studied with a sensitive radioimmunoassay for albumin using 24-h urine samples. Patients with overt nephropathy are discussed in Chapter 42.
KeywordsMean Arterial Pressure Normal Pregnancy Proliferative Diabetic Retinopathy Urinary Albumin Excretion Urinary Albumin Excretion Rate
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