Antihypertensive Treatment in NIDDM, with Special Reference to Abnormal Albuminuria

  • Mark E. Cooper
  • Paul G. McNally


The deleterious effects of systemic blood pressure on glomerular structure were reported more than twenty years ago in a patient with NIDDM and unilateral renal artery stenosis, in which characteristic nodular diabetic glomerulosclerosis was present in the non-ischaemic kidney only [1]. Nevertheless, to date the impact of antihypertensive therapy on renal injury in NIDDM has received little attention even though the cumulative incidence of persistent proteinuria and microalbuminuria in NIDDM subjects is comparable in frequency to IDDM subjects of similar duration [2–5]. The clinical relevance of these figures is reflected by statistics which now show that over 50% of patients entering renal replacement programs have NIDDM [6–8]. Furthermore, in NIDDM the relationship between nephropathy and hypertension is more complex than in IDDM, since hypertension is not necessarily linked to the presence of renal disease, and often precedes the diagnosis of diabetes.


Diabetic Nephropathy Antihypertensive Agent Antihypertensive Treatment Renal Artery Stenosis NIDDM Patient 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Mark E. Cooper
    • 1
    • 2
  • Paul G. McNally
    • 1
    • 2
  1. 1.Department of MedicineUniversity of Melbourne, Austin & Repatriation Medical CentreWest HeidelbergAustralia
  2. 2.Leicester Royal Infirmary NHS TrustLeicesterUnited Kingdom

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