Volume Homeostasis and Blood Pressure in Diabetic States

  • James A. O’Hare
  • J. Barry Ferriss


The final determinants of arterial blood pressure are cardiac output and systemic vascular resistance [1]. Cardiac output is determined by extracellular fluid (and blood volume) and filling pressure. Peripheral resistance is influenced by a host of factors, with the renin-angiotensin-aldosterone axis, atrial natriuretic peptide and the sympathetic nervous system playing the leading neuroendocrine roles in volume/resistance homeostasis.


Diabetic Nephropathy Atrial Natriuretic Peptide Plasma Renin Activity Sodium Retention Exchangeable Sodium 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • James A. O’Hare
    • 1
    • 2
  • J. Barry Ferriss
    • 1
    • 2
  1. 1.Diabetes UnitLimerick Regional General HospitalDooradoyle, LimerickIreland
  2. 2.Department of MedicineCork University HospitalWilton, CorkIreland

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