Sodium-Hydrogen Antiport, Cell Function and Susceptibility to Diabetic Nephropathy

  • Roberto Trevisan
  • GianCarlo Viberti


The annual incidence of diabetic nephropathy rises rapidly over the first 15–20 years of diabetes, but declines sharply afterward for longer disease duration [1]. This pattern of risk indicates that only a subset of diabetic patients are susceptible to renal damage and, indeed, clinical renal disease cumulatively develops in approximately 30% of insulin-dependent diabetic (IDDM) patients [2] and between 15 and 60% of non-insulin-dependent diabetic (NIDDM) patients, depending on their ethnic origin [3]. Familial clustering of diabetic nephropathy has been shown both in IDDM [4] and NIDDM patients [5]. These findings are consistent with the possibility that genetic factors may explain the liability to or protection from renal disease of diabetic patients.


Diabetic Patient Diabetic Nephropathy Essential Hypertension NIDDM Patient Raise Blood Pressure 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Roberto Trevisan
    • 1
    • 2
  • GianCarlo Viberti
    • 1
    • 2
  1. 1.Instituto di Medicina ClinicaUniversità di PadovaPadovaItaly
  2. 2.Division of MedicineGuy’s and St Thomas’s Medical and Dental SchoolLondonUnited Kingdom

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