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Abstract

Microalbuminuria defined as an increase in urinary albumin excretion rate to the range 20–200 μg/min not only predicts later development of nephropathy in diabetic subjects [1–4] but may also guide the detection or prediction of other complications e.g. proliferative retinopathy [5,6]. In addition, microalbuminuria is also strongly associated with cardiovascular risk factors and coronary heart disease in diabetic as well as non-diabetic patients [7,8].

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References

  1. Viberti GC, Hill RD, Jarrett RJ, Argyropoulos A, Mahmud U, Keen H. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet 1982; 1: 1430–1432.

    Article  PubMed  CAS  Google Scholar 

  2. Parving H-H, Oxenb0ll B, Johansen K, Svendsen PA, Christiansen JS, Andersen AR. Early detection of patients at risk of developing diabetic nephropathy: a longitudinal study of urinary albumin excretion. Acta Endocrinol (Copenh) 1982; 100: 500–505.

    Google Scholar 

  3. Mogensen CE, Christensen CK. Predicting diabetic nephropathy in insulin-dependent patients. N Engl J Med 1984; 311: 89–93.

    Article  PubMed  CAS  Google Scholar 

  4. Mathiesen ER, Oxenboll B, Johansen K, Svendsen PA, Deckert T. Incipient nephropathy in type 1 (insulin-dependent) diabetes. Diabetologia 1984; 26: 406–410.

    Article  PubMed  CAS  Google Scholar 

  5. Vigstrup J, Mogensen CE. Proliferative diabetic retinopathy: at risk patients identified by early detection of microalbuminuria. Acta Ophthalmol (Copenh) 1985; 63: 530–534.

    Article  CAS  Google Scholar 

  6. Parving H-H, Hommel E, Mathiesen E. Prevalence of microalbuminuria, arterial hypertension, retinopathy and neuropathy in patients with insulin dependent diabetes mellitus. BMJ 1988; 296: 156–160.

    Article  PubMed  CAS  Google Scholar 

  7. Damsgaard EM, Freland A, Jergensen OD, Mogensen CE. Microalbuminuria as a predictor of increased mortality in elderly people. BMJ 1990; 300: 297–300.

    Article  PubMed  CAS  Google Scholar 

  8. Yudkin JS, Forrest RD, Jackson CA. Microalbuminuria as a predictor of vascular disease in non-diabetic subjects. Lancet 1988; 1: 530–533.

    Article  Google Scholar 

  9. Marre M, Chatellier G, Leblanc H, Guyene TT, Menard J, Passa P. Prevention of diabetic nephropathy with enalapril in normotensive diabetics with microalbuminuria. BMJ 1988; 297: 1092–1095.

    Article  PubMed  CAS  Google Scholar 

  10. Mathiesen ER, Hommel E, Giese J, Parving H-H. Efficacy of Captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. BMJ 1991; 303: 81–87.

    Article  PubMed  CAS  Google Scholar 

  11. Hallab M, Gallois Y, Chatellier G, Rohmer V, Fressinaud P, Marre M. Comparison of reduction in microalbuminuria by enalapril and hydrochlorothiazide in normotensive patients with insulin dependent diabetes. BMJ 1993; 306: 175–182.

    Article  PubMed  CAS  Google Scholar 

  12. Mogensen CE, on behalf of the European Microalbuminuria Captopril Study Group. Captopril delays progression to overt renal disease in insulin dependent diabetes mellitus with microalbuminuria. J Am Soc Nephrol 1992; 3: 336(A).

    Google Scholar 

  13. The Kroc Collaborative Study Group. Blood glucose control and the evolution of diabetic retinopathy and albuminuria. N Engl J Med 1984; 311: 365–372.

    Article  Google Scholar 

  14. Reichard P, Nilsson BY, Rosenqvist U. The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. N Engl J Med 1993; 329: 304–309.

    Article  PubMed  CAS  Google Scholar 

  15. Feldt-Rasmussen B, Mathiesen ER, Jensen T, Lauritzen T, Deckert T. Effect of improved metabolic control on loss of kidney function in type 1 (insulin-dependent) diabetic patients: an update of the Steno studies. Diabetologia 1991; 34: 164–170.

    Article  PubMed  CAS  Google Scholar 

  16. Borch-Johnsen K, Wenzel H, Viberti GC, Mogensen CE. Is screening and intervention for microalbuminuria worthwhile in patients with insulin dependent diabetes? BMJ 1993; 306: 1722–1723.

    Article  PubMed  CAS  Google Scholar 

  17. Feldt-Rasmussen B, Mathiesen ER. Variability of urinary excretion in incipient diabetic nephropathy. Diabetic Nephropathy 1984; 3: 101–103.

    Google Scholar 

  18. Johnston J, Paterson KR, O’Reilly D. Estimating urinary albumin excretion rate of diabetic patients in clinical practice. BMJ 1993; 306: 493–494.

    Article  PubMed  CAS  Google Scholar 

  19. Marshall SM, Alberti KG. Comparison of the prevalence and associated features of abnormal albumin excretion in insulin-dependent and non-insulin-dependent diabetes. Q J Med 1989; 70: 61–71.

    PubMed  CAS  Google Scholar 

  20. Hutchison AS, Paterson KR. Collecting urine for microalbumin assay. Diabetic Med 1988; 5: 527–532.

    Article  PubMed  CAS  Google Scholar 

  21. Gatling W, Knight C, Hill RD. Screening for early diabetic nephropathy: Which sample to detect microalbuminuria? Diabetic Med 1985; 2: 451–455.

    Article  PubMed  CAS  Google Scholar 

  22. Krolewski AS, Warram JH, Christlieb AR. The changing natural history of nephropathy in type I diabetes. Am J Med 1985; 78: 785–794.

    Article  PubMed  CAS  Google Scholar 

  23. Schmitz A. Microalbutest: A new screening method for detection of microalbuminuria in diabetes mellitus. Uremia Invest 1985; 9: 79–84.

    Google Scholar 

  24. Leedman PJ, Nankervis A, Goodwin M, Ratnaike S. Assessment of the albuscreen microalbuminuria kit in diabetic outpatients. Med J Aust 1987; 147: 285–286.

    PubMed  CAS  Google Scholar 

  25. Collins V, Zimmet P, Dowse GK, Finch CF. Performance of Micro-Bumintest tablets for detection of microalbuminuria in Nauruaans. Diabetes Res Clin Pract 1989; 6: 271–277.

    Article  PubMed  CAS  Google Scholar 

  26. Coonrod BA, Ellis D, Becker DJ, et al. Assessment of AlbuSure and its usefulness in identifying IDDM subjects at increased risk for developing clinical diabetic nephropathy. Diabetes Care 1989; 12: 389–393.

    Article  PubMed  CAS  Google Scholar 

  27. Bangstad HJ, Try K, Dahl Jergensen K, Hanssen KF. New semiquantitative dipstick test for microalbuminuria. Diabetes Care 1991; 14: 1094–1097.

    Article  PubMed  CAS  Google Scholar 

  28. Jury DR, Mikkelsen DJ, Glen D, Dunn PJ. Assessment of Mic ral-Test microalbuminuria test strip in the laboratory and in diabetic outpatients. Ann Clin Biochem 1992; 29: 96–100.

    PubMed  Google Scholar 

  29. Poulsen PL, Hansen B, Amby T, Terkelsen T, Mogensen CE. Evaluation of a dipstick test for microalbuminuria in three different clinical settings, including the correlation with urinary albumin excretion rate. Diabete Metab 1992; 18: 395–400.

    PubMed  CAS  Google Scholar 

  30. Marshall SM, Shearing PA, Alberti KG. Micral-Test strips evaluated for screening for albuminuria. Clin Chem 1992; 38: 588–591.

    PubMed  CAS  Google Scholar 

  31. Agardh CD. A new semiquantitative rapid test for screening for microalbuminuria. Pract Diabetes 1993; 10: 146–147.

    Article  Google Scholar 

  32. Adamson CL, Kumar S, Sutcliffe H, France MW, Boulton AJM. Screening for strategies in the detection of microalbuminuria in insulin-dependent diabetic patients. Pract Diabetes 1993; 10: 142–144.

    Article  Google Scholar 

  33. Collwell M, Hasey JF. High incidense of false positive albuminuria results with the with the Micro-Bumintest. Clin Chem 1989; 35: 1252.

    Google Scholar 

  34. Jung K, Nickel E. Nonprotein components of urine interfere with colourimetry of urinary albumin with bromphenol blue. Clin Chem 1989; 35: 336–337.

    PubMed  CAS  Google Scholar 

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© 1994 Springer Science+Business Media New York

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Poulsen, P.L. (1994). Office Tests for Microalbuminuria. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6746-9_9

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  • DOI: https://doi.org/10.1007/978-1-4757-6746-9_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6748-3

  • Online ISBN: 978-1-4757-6746-9

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